Prenatal, perinatal and neonatal risk factors of Autism Spectrum Disorder: A comprehensive epidemiological assessment from India

Mamidala, Madhu; Polinedi, Anupama; P.T.V., Praveen Kumar; Rajesh, N.; Vallamkonda, Omsai Ramesh; Udani, Vrajesh; Singhal, Nidhi; Rajesh, Vidya

doi:10.1016/j.ridd.2013.06.019

Cited by 68 publications

(91 citation statements)

References 81 publications

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“…Studies also suggest a link between extreme prematurity and autism spectrum disorder (ASD), characterised by persistent deficits in social communication and social interaction, and restrictive and repetitive patterns of behaviours, interests or activities (10). Prematurity and low birth weight are considered to be risk factors for ASD (11)(12)(13)(14)(15)(16)(17). Two recent studies even found a gradual increased risk of traits of ASD with shorter gestation (18,19).…”

Section: Introductionmentioning

confidence: 99%

Extremely Preterm Born Children at Very High Risk for Developing Autism Spectrum Disorder

Verhaeghe

Dereu

Warreyn

et al. 2015

Child Psychiatry Hum Dev

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This study aimed to provide a more comprehensive picture of the prevalence of autism spectrum disorder (ASD) in a geographic cohort of extremely preterm born adolescents by using established diagnostic instruments in addition to screening instruments. 53 participants passed a screening procedure with two screening instruments and a diagnostic evaluation with a semistructured assessment and a parent interview. 28% of the adolescents had a community based clinical diagnosis of ASD. When research diagnoses were also taken into account, this rate increased to 40%. Intellectual disability, language impairment and behavioural difficulties are characteristic for these children with ASD. This study is to our knowledge the first to use ASDspecific diagnostic instruments to confirm ASD diagnoses in extremely preterm born children in early adolescence. The study expands findings of previous research and raises the need for follow-up into late childhood and early adolescence.

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Section: Introductionmentioning

confidence: 99%

Extremely Preterm Born Children at Very High Risk for Developing Autism Spectrum Disorder

Verhaeghe

Dereu

Warreyn

et al. 2015

Child Psychiatry Hum Dev

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“…Even though in the last decade, the number of publications that address epidemiological factors and autism has grown tremendously. Although there are numerous risk factors (prenatal, perinatal, and postnatal risk factors) that have been linked to autism [203][204][205][206], in some cases their involvement has been or is still considered controversial, and as a possible hypothesis, postulates that improvements in obstetric and neonatal management have resulted in an increased frequency of survivors with preexisting brain damage, which has subsequently led to autism [203]. For each infant, an environmental challenge during a critical window of development can have particularly serious consequences, causing the abnormal functioning of the CNS, perhaps autism.…”

Section: Acquired Epigenetics Disorders In Asdmentioning

confidence: 99%

The Genetic and Epigenetic Basis Involved in the Pathophysiology of ASD: Therapeutic Implications

Carrascosa-Romero¹,

Cabo²

2017

Autism - Paradigms, Recent Research and Clinical Applications

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The prevalence of autism has increased in an exponential way in the past few years. Many monogenetic mutations as well as copy number variants and single nucleotide polymorphisms have been associated with autism spectrum disorders (ASD), a large proportion of which occur in genes associated with synaptogenesis and synaptic function. However, the increase in appearance of genetic alterations does not explain the etiology of an elevated number of ASD cases. Recent research is now focusing on the role of environmental/epigenetic factors, which by themselves and/or in combination with classical genetic factors, may be the root cause of a large number of ASDs. In this chapter we review the current literature regarding the epigenetic changes involved in ASD, including their possible mechanisms of action such as oxidative stress, altered fatty acid metabolism, mitochondrial dysfunction, DNA methylation and histone methylation (via the one-carbon metabolism cycle), histone variants, and ATP-dependent chromatin remodeling. We discuss possible new biochemical markers related to autism as well as new lines of research for therapeutic targets.

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“…It is less clear whether there is similar association between maternal gestational diabetes mellitus (GDM) and ASD in the offspring [5][6][7][8].…”

Section: Introductionmentioning

confidence: 99%

The association of maternal gestational diabetes mellitus with autism spectrum disorders in the offspring

Kania

Herbut

Dybała

et al. 2017

Clinical Diabetology

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Prenatal, perinatal and neonatal risk factors of Autism Spectrum Disorder: A comprehensive epidemiological assessment from India

Cited by 68 publications

References 81 publications

Extremely Preterm Born Children at Very High Risk for Developing Autism Spectrum Disorder

Extremely Preterm Born Children at Very High Risk for Developing Autism Spectrum Disorder

The Genetic and Epigenetic Basis Involved in the Pathophysiology of ASD: Therapeutic Implications

The association of maternal gestational diabetes mellitus with autism spectrum disorders in the offspring

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