Prenatal paracetamol exposure and child neurodevelopment: a sibling-controlled cohort study

Abstract

Children exposed to long-term use of paracetamol during pregnancy had substantially adverse developmental outcomes at 3 years of age.

Suboptimal Maternal Iodine Intake Is Associated with Impaired Child Neurodevelopment at 3 Years of Age in the Norwegian Mother and Child Cohort Study

“…Mean scores were calculated and standardized. Previous studies reported adequate reliability for the externalizing and internalizing behavior scales (30). The subset of items used in MoBa has been found to be representative (34).…”

“…Mean scores were calculated and standardized. Good reliability of the scale in MoBa was previously demonstrated with the use of a 2-parameter item response theory analysis (mean factor loading: 0.82) (30).…”

Medication safety in pregnancy – Results from the MoBa study

“…In our most recent study published we found that three year old children who had been exposed to paracetamol (=acetaminophen) for more than 28 days during fetal life had poorer gross motor development, communications skills and more externalizing problems compared to their unexposed siblings (21). The effect size was approximately one quarter of a standard deviation (e.g.…”

The Norwegian Mother and Child Cohort Study (MoBa) – past, present and future

“…We have also performed exome sequencing for a smaller number of trios with the aims of detecting de novo mutations and the presence of rare disease-promoting alleles and chromosomal changes associated with autism spectrum disorders. The discordant co-sibling design is increasingly used among the large number of sibships in MoBa, one example being the finding that prolonged intake of paracetamol in pregnancy was associated with adverse child developmental outcomes at three years (27).…”