Prenatal omega 3 fatty acid supplementation to a micronutrient imbalanced diet protects brain neurotrophins in both the cortex and hippocampus in the adult rat offspring

Sable, Pratiksha; Kale, Anvita; Joshi, Sadhana

doi:10.1016/j.metabol.2013.06.002

Cited by 38 publications

(33 citation statements)

References 70 publications

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“…It has been reported that truncated isoforms like TrkB-T1 opposes TrkB function via competition for BDNF binding or the formation of inactive heterodimers [55]. Further, the cognitive performance of the offspring in the vitamin B 12 supplemented group was comparable to the control group. A previous study has reported that maternal vitamin B 12 status influences cognitive function in the children [56].…”

Section: Figmentioning

confidence: 84%

“…Further, these offspring when tested using the eight arm radial maze made less percentage of correct choices and more errors suggesting impairment in working and reference memory [45]. We have earlier demonstrated that maternal vitamin B 12 deficiency showed increased homocysteine levels in the offspring and the dams [12,45]. Reports indicate that increase in homocysteine levels also contributes to cognitive impairment [46].…”

Section: Figmentioning

confidence: 95%

“…Vitamin B 12 and omega-3 fatty acids have been widely studied in context of brain development and functioning [2][3][4][5]. Vitamin B 12 is a key component of the one carbon cycle and its deficiency is associated with high levels of homocysteine which is an important risk factor for neurological and cognitive impairment [6,7].…”

Section: Introductionmentioning

confidence: 99%

“…We have earlier reported that maternal vitamin B 12 status influences brain DHA and neurotrophins levels in the offspring [9][10][11][12][13]. A series of studies in our department have also explored the possible interactions between micronutrients (folic acid, vitamin B 12 ) and omega-3…”

Section: Introductionmentioning

confidence: 99%

“…A recent study has demonstrated that long-term fish oil supplementation for two generations increases insulin sensitivity in rats [34]. However, there are no studies which have examined the effect of long-term supplementation of omega-3 fatty acids with and without vitamin B 12 on possible mechanisms underlying brain development.…”

Section: Introductionmentioning

confidence: 99%

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Beneficial effects of omega‐3 fatty acids and vitamin B₁₂ supplementation on brain docosahexaenoic acid, brain derived neurotrophic factor, and cognitive performance in the second‐generation Wistar rats

et al. 2015

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In vegetarian population, vitamin B12 deficiency coexists with suboptimal levels of omega-3 fatty acids. Studies indicate a need for supplementation/fortification of vitamin B12 and omega-3 fatty acids to reduce the risk of brain disorders. We have described the effects of vitamin B12 and omega-3 fatty acid supplementation on brain development in F1 generation animals. The current study investigates the effects of vitamin B12 and omega-3 fatty acids supplementation on brain function and cognition. Pregnant Wistar rats were assigned the following groups: control, vitamin B12 deficient (BD), vitamin B12 deficient + omega-3 fatty acid (BDO), vitamin B12 supplemented (BS), vitamin B12 supplemented + omega-3 fatty acid (BSO). The same diets were continued for two generations. BDO group showed higher (P < 0.05) levels of BDNF (brain derived neurotrophic factor) and DHA (docosahexaenoic acid) in the cortex and hippocampus as compared with the BD group. The cognitive performance was also normalized in this group. BS showed comparable levels of DHA, BDNF (protein and mRNA), and CREB mRNA (cAMP response element-binding protein) to that of control group while Tropomyosin receptor kinase mRNA levels were higher. The combined vitamin B12 and omega-3 fatty acid supplementation further enhanced the levels of DHA (P < 0.05) and BDNF (P < 0.05) in the hippocampus and CREB mRNA (P < 0.01) in the cortex as compared with BS group. The cognitive performance of these animals was higher (P < 0.05) as compared with BS group. Our data indicates the beneficial effects of vitamin B12 and omega-3 fatty acid supplementation across two generations on brain development and function.

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Section: Figmentioning

confidence: 84%