PRENATAL NUTRITION OF POULTRY AND ITS POSTNATAL EFFECTS (review)

Dolgorukova, A. M.

doi:10.15389/agrobiology.2020.6.1061eng

Cited by 1 publication

(1 citation statement)

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“…Further, to characterize the physiological effects of catechin and its short-chain ester derivatives on brush border membrane (BBM) functionality, intestinal morphology, and intestinal microbial populations, we utilized the in vivo Gallus gallus model. The Gallus gallus has been used as a novel and cost-effective animal model to elucidate the physiological effects of plant bioactives and nutritional solutions relevant to human nutrition [ 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ]. Recently, the positive impact of catechins, as food additives, on poultry growth performance and egg quality has been studied and found to improve poultry antioxidant status [ 41 , 42 ].…”

Section: Introductionmentioning

confidence: 99%

Alterations in Intestinal Brush Border Membrane Functionality and Bacterial Populations Following Intra-Amniotic Administration (Gallus gallus) of Catechin and Its Derivatives

et al. 2022

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Catechin is a flavonoid naturally present in numerous dietary products and fruits (e.g., apples, berries, grape seeds, kiwis, green tea, red wine, etc.) and has previously been shown to be an antioxidant and beneficial for the gut microbiome. To further enhance the health benefits, bioavailability, and stability of catechin, we synthesized and characterized catechin pentaacetate and catechin pentabutanoate as two new ester derivatives of catechin. Catechin and its derivatives were assessed in vivo via intra-amniotic administration (Gallus gallus), with the following treatment groups: (1) non-injected (control); (2) deionized H2O (control); (3) Tween (0.004 mg/mL dose); (4) inulin (50 mg/mL dose); (5) Catechin (6.2 mg/mL dose); (6) Catechin pentaacetate (10 mg/mL dose); and (7) Catechin pentabutanoate (12.8 mg/mL dose). The effects on physiological markers associated with brush border membrane morphology, intestinal bacterial populations, and duodenal gene expression of key proteins were investigated. Compared to the controls, our results demonstrated a significant (p < 0.05) decrease in Clostridium genera and E. coli species density with catechin and its synthetic derivative exposure. Furthermore, catechin and its derivatives decreased iron and zinc transporter (Ferroportin and ZnT1, respectively) gene expression in the duodenum compared to the controls. In conclusion, catechin and its synthetic derivatives have the potential to improve intestinal morphology and functionality and positively modulate the microbiome.

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