Prenatal nonylphenol exposure, oxidative and nitrative stress, and birth outcomes: A cohort study in Taiwan

Wang, Pei Wei; Chen, Mei Lien; Huang, Liying; Yang, Winnie; Wu, Kaung-Hsiung; Huang, Yu Fang

doi:10.1016/j.envpol.2015.08.044

Cited by 32 publications

(26 citation statements)

References 51 publications

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“…A cohort study of 146 pregnant women in Taiwan reported that NP exposure significantly raised maternal urinary 8‐hydroxy‐2′‐deoxyguanosine (8‐OHdG) and 8‐nitroguanine (8‐NO 2 Gua) levels. All pregnant women with urinary 8‐OHdG levels above the median exhibited smaller gestational age, but no clear association was observed between NP levels and neonatal birth outcomes (i.e., birth weights, length, Ponderal index, and head and chest circumferences) (Wang et al, ). Though it has been reported that in animals, maternal exposure of NP may affect bw and some organ weights, such as liver, kidney and ovary, and induce reproductive toxic effects in offspring (Cha et al, ; Hossaini, Dalgaard, Vinggaard, Frandsen, & Larsen, ; Jie et al, ; Nagao, Wada, Marumo, Yoshimura, & Ono, ), given the above inconsistent human studies, more research is still needed for maternal exposure of NP and offspring health outcomes.…”

Section: Resultsmentioning

confidence: 99%

“…8‐OHdG and 8‐NO 2 Gua are used as oxidative stress biomarkers of DNA damage. Wang et al () indicated NP increased urinary 8‐OHdG and 8‐NO 2 Gua levels in pregnant women, and 8‐OHdG levels above the median induced smaller gestational age, without changes in neonatal birth outcomes. However, the levels of 8‐OHdG is affected by a number of confounding factors in a real‐life scenario, and urinary 8‐OHdG is less sensitive than plasma 8‐OHdG as an oxidative DNA biomarker (Pilger & Rudiger, ; Wang et al, ).…”

Section: Resultsmentioning

confidence: 99%

“… Gua are used as oxidative stress biomarkers of DNA damage Wang et al (2015). indicated NP increased urinary 8-OHdG and 8-NO 2 Gua levels in pregnant women, and 8-OHdG levels above the median induced smaller gestational age, without changes in neonatal birth outcomes.…”

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confidence: 99%

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An updated weight of evidence approach for deriving a health‐based guidance value for 4‐nonylphenol

Huo

Liu

et al. 2018

J of Applied Toxicology

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4-Nonylphenol (NP) is a persistent estrogen-active compound. Human exposure to NP is primarily through water and food. Although risk assessments of NP have been conducted by the European Union and a few other countries, only the Danish Veterinary and Food Administration, in 2000, proposed a tolerable daily intake of 0.005 mg kg body weight (bw) day . New data have been accumulated since then, prompting an update on the risk assessment of NP. A weight of evidence approach is recommended for use in scientific assessments by several agencies, e.g., European Food Safety Authority, etc. Based on the results of a weight of evidence approach, two methods were used to derive the health-based guidance value (HBGV) for NP in this study, namely a no observed adverse effects level/lowest observable adverse effect level method, and a benchmark dose method. Considering the considerable uncertainty of benchmark dose model fitting of the available data, a tolerable daily intake value of 0.025 mg kg bw day was derived as a provisional HBGV for NP based on the lowest observable adverse effect level value of 15 mg kg bw day of the renal toxicity in rats, together with the uncertainty factor of 600. However, the HBGV of NP still needs further investigation.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

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An updated weight of evidence approach for deriving a health‐based guidance value for 4‐nonylphenol

Huo

Liu

et al. 2018

J of Applied Toxicology

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“…The US National Health and Nutrition Examination Survey (NHANES) III reported that the geometric mean of urinary 4-NP level was below the LOD (0.1 ng/mL) for the US adult population [ 20 ]. On the other hand, several studies conducted in Taiwan showed that the geometric mean of urinary 4-NP concentration was 2.90–4.10 ng/mL for Taiwanese pregnant women with a mean age range of 31.0–33.4 years [ 21 , 22 , 23 , 24 ]. Given that 4-NP levels do not significantly differ by sex, the geometric mean of urinary 4-NP concentration in the Korean population is assumed to be similar to that in the Taiwanese population and much higher than that in the U.S. population.…”

Section: Discussionmentioning

confidence: 99%

Urinary Levels of 4-Nonylphenol and 4-t-Octylphenol in a Representative Sample of the Korean Adult Population

Park

Kim

2017

IJERPH

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4-Nonylphenol (4-NP) and 4-t-octylphenol (4-t-OP) are xenoestrogen compounds to which humans are exposed via contaminated food, water, and air. This study assessed the body burden of 4-NP and 4-t-OP in Koreans aged 18–69 years using data from the Korean National Human Biomonitoring Survey conducted in 2009. Based on data from 1865 representative Koreans, 83.2% and 91.8% had urinary 4-NP and 4-t-OP concentrations >0.05 ng/mL (limit of detection). Of the Korean adult population, the geometric mean urinary concentrations of 4-NP and 4-t-OP were 3.70 ng/mL (95% confidence interval (CI) = 3.20–4.27) and 0.60 ng/mL (95% CI = 0.55–0.66), respectively. Urine 4-NP concentrations were significantly associated with place of residence and smoking status, whereas urine 4-t-OP concentrations were not correlated with any of the demographic factors. These findings suggest that most Koreans have detectable levels of 4-NP and 4-t-OP in their urine and that the body burden of 4-NP, but not 4-t-OP, varies according to some demographic factors.

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“…A large number of reports indicated that NP had an influence on the anti-oxidative balance of cells and therefore triggered oxidative stress [ 37 ]. The increase in the malondialdehyde concentration and decrease in the glutathione level implied the increase of oxyradical generation [ 38 ].…”

Section: Discussionmentioning

confidence: 99%

Nonylphenol Toxicity Evaluation and Discovery of Biomarkers in Rat Urine by a Metabolomics Strategy through HPLC-QTOF-MS

Zhang

Yang

Pan

et al. 2016

IJERPH

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Nonylphenol (NP) was quantified using liquid chromatography tandem mass spectrometry (LC-MS/MS) in the urine and plasma of rats treated with 0, 50, and 250 mg/kg/day of NP for four consecutive days. A urinary metabolomic strategy was originally implemented by high performance liquid chromatography time of flight mass spectrometry (HPLC-QTOF-MS) to explore the toxicological effects of NP and determine the overall alterations in the metabolite profiles so as to find potential biomarkers. It is essential to point out that from the observation, the metabolic data were clearly clustered and separated for the three groups. To further identify differentiated metabolites, multivariate analysis, including principal component analysis (PCA), orthogonal partial least-squares discriminant analysis (OPLS-DA), high-resolution MS/MS analysis, as well as searches of Metlin and Massbank databases, were conducted on a series of metabolites between the control and dose groups. Finally, five metabolites, including glycine, glycerophosphocholine, 5-hydroxytryptamine, malonaldehyde (showing an upward trend), and tryptophan (showing a downward trend), were identified as the potential urinary biomarkers of NP-induced toxicity. In order to validate the reliability of these potential biomarkers, an independent validation was performed by using the multiple reaction monitoring (MRM)-based targeted approach. The oxidative stress reflected by urinary 8-oxo-deoxyguanosine (8-oxodG) levels was elevated in individuals highly exposed to NP, supporting the hypothesis that mitochondrial dysfunction was a result of xenoestrogen accumulation. This study reveals a promising approach to find biomarkers to assist researchers in monitoring NP.

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Prenatal nonylphenol exposure, oxidative and nitrative stress, and birth outcomes: A cohort study in Taiwan

Cited by 32 publications

References 51 publications

An updated weight of evidence approach for deriving a health‐based guidance value for 4‐nonylphenol

An updated weight of evidence approach for deriving a health‐based guidance value for 4‐nonylphenol

Urinary Levels of 4-Nonylphenol and 4-t-Octylphenol in a Representative Sample of the Korean Adult Population

Nonylphenol Toxicity Evaluation and Discovery of Biomarkers in Rat Urine by a Metabolomics Strategy through HPLC-QTOF-MS

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