Prenatal NO<sub>2</sub>exposure and ultrasound measures of foetal growth: a prospective cohort study in Wuhan, China

Wang, Weiye; Zhong, Chunrong; Huang, Li; Zhou, Xian; Chen, Renjuan; Wu, Jiangyue; Li, Xiating; Xiong, Ting; Liu, Chaoqun; Xiao, Mei; Yang, Xuefeng; Hao, Liping; Yang, Nianhong; Wei, Sheng

doi:10.1136/oemed-2016-103980

Cited by 13 publications

(3 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Common among these studies are assessments that examine exposures averaged across multiple weeks, months, or trimesters. Wang et al 16 reported associations between NO 2 exposure aggregated across the first 22 weeks of pregnancy with changes in BPD, AC, and FL from the second and third trimesters. A study of Korean women 15 also revealed reductions in fetal head size and length between the second and third trimesters associated with aggregated NO 2 exposure across the entire pregnancy period.…”

Section: Discussionmentioning

confidence: 99%

“…2 Moreover, all studies included in that review assessed exposure aggregated by trimester or by periods approximating trimesters (e.g., early, mid-, and late-pregnancy). Although six additional studies [11][12][13][14][15][16] have been published since July 2017 (the date before which studies included in the Fu et al 2 review was published), only three to our knowledge have since examined NO 2 exposure. [14][15][16] While these three studies each provide further evidence of associations between NO 2 exposures and altered fetal growth, they have also relied on relatively large exposure windows (e.g., trimesters) hindering their ability to evaluate sensitive windows of exposure.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Identifying Sensitive Windows of Exposure to NO2 and Fetal Growth Trajectories in a Spanish Birth Cohort

et al. 2022

View full text Add to dashboard Cite

Background:We previously identified associations between trimester-specific NO 2 exposures and reduced fetal growth in the Spanish INfancia y Medio Ambiente (INMA) project. Here, we use temporally refined exposure estimates to explore the impact of narrow (weekly) windows of exposure on fetal growth. Methods: We included 1,685 women from INMA with serial ultrasounds at 12, 20, and 34 gestational weeks. We measured biparietal diameter (BPD), femur length, and abdominal circumference (AC) and from them calculated estimated fetal weight (EFW). We calculated z-scores describing trajectories of each parameter during early (0-12 weeks), mid (12-20 weeks), and late (20-34 weeks) pregnancy, based on longitudinal growth curves from mixed-effects models. We estimated weekly NO 2 exposures at each woman's residence using land-use regression models. We applied distributed lag nonlinear models to identify sensitive windows of exposure. We present effect estimates as the percentage change in fetal growth per 10 μg/ m 3 increase in NO 2 exposure, and we calculated cumulative effect estimates by aggregating estimates across adjacent lags. Results: We identified weeks 5-12 as a sensitive window for NO 2 exposure on late EFW (cumulative β = −3.0%; 95% CI = −4.1%, −1.9%).We identified weeks 6-19 as a sensitive window for late growth in BPD (cumulative β = −2.0%; 95% CI = −2.7%, −1.4%) and weeks 8-13 for AC (cumulative β = −0.68%; 95% CI = −0.97%, −0.40%). We found suggestive evidence that third trimester NO 2 exposure is associated with increased AC, BPD, and EFW growth in late pregnancy. Conclusions: Our findings are consistent with the hypothesis that NO 2 exposure is associated with alterations in growth of EFW, BPD, and AC dependent on the specific timing of exposure during gestation.

show abstract

Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Identifying Sensitive Windows of Exposure to NO2 and Fetal Growth Trajectories in a Spanish Birth Cohort

et al. 2022

View full text Add to dashboard Cite

show abstract

“…An observational study in Spain found that nitrogen dioxide (NO 2 ) exposure during pregnancy was associated with decreased biparietal diameter, abdominal circumference, and estimated fetal weight [ 28 – 30 ]. NO 2 also has been associated with significant inverse effects on fetal growth in observational cohorts in Los Angeles, California [ 31 ], China [ 32 ], and the Netherlands [ 33 ]. Additionally, studies have shown PM with an aerodynamic diameter of 10 m or less (PM 10 ) [ 31 , 33 – 37 ] and PM 2.5 [ 34 , 38 – 40 ] have adverse effects on fetal growth.…”

Section: Introductionmentioning

confidence: 99%

Identifying pre-conception and pre-natal periods in which ambient air pollution exposure affects fetal growth in the predominately Hispanic MADRES cohort

et al. 2022

View full text Add to dashboard Cite

Background It is well documented that persons of color experience disproportionate exposure to environmental contaminants, including air pollution, and have poorer pregnancy outcomes. This study assessed the critical windows of exposure to ambient air pollution on in utero fetal growth among structurally marginalized populations in urban Los Angeles. Methods Participants (N = 281) from the larger ongoing MADRES pregnancy cohort study were included in this analysis. Fetal growth outcomes were measured on average at 32 $$\pm$$ ± 2 weeks of gestation by a certified sonographer and included estimated fetal weight, abdominal circumference, head circumference, biparietal diameter and femur length. Daily ambient air pollutant concentrations were estimated for four pollutants (particulate matter less than 2.5 µm (PM2.5) and less than 10 µm (PM10) in aerodynamic diameter, nitrogen dioxide (NO2), and 8-h maximum ozone (O3)) at participant residences using inverse-distance squared spatial interpolation from ambient monitoring data. Weekly gestational averages were calculated from 12 weeks prior to conception to 32 weeks of gestation (44 total weeks), and their associations with growth outcomes were modeled using adjusted distributed lag models (DLMs). Results Participants were on average 29 years $$\pm$$ ± 6 old and predominately Hispanic (82%). We identified a significant sensitive window of PM2.5 exposure (per IQR increase of 6 $$\mathrm{\mu g}/\mathrm{m}$$ μ g / m 3) between gestational weeks 4–16 for lower estimated fetal weight $$\beta$$ β averaged4-16 = -8.7 g; 95% CI -16.7, -0.8). Exposure to PM2.5 during gestational weeks 1–23 was also significantly associated with smaller fetal abdominal circumference ($$\beta$$ β averaged1-23 = -0.6 mm; 95% CI -1.1, -0.2). Additionally, prenatal exposure to PM10 (per IQR increase of 13 $$\mathrm{\mu g}/\mathrm{m}$$ μ g / m 3) between weeks 6–15 of pregnancy was significantly associated with smaller fetal abdominal circumference ($$\beta$$ β averaged6-15 = -0.4 mm; 95% CI -0.8, -0.1). Discussion These results suggest that exposure to particulate matter in early to mid-pregnancy, but not preconception or late pregnancy, may have critical implications on fetal growth.

show abstract

Effects of Maternal Environmental Exposure on Early Life Growth and Development

Wang

Tian

2023

In Utero Pediatrics

View full text Add to dashboard Cite

Prenatal NO₂exposure and ultrasound measures of foetal growth: a prospective cohort study in Wuhan, China

Abstract: In this prospective study of Chinese women, maternal NO exposure was inversely associated with foetal growth, and the association was stronger among female babies and smoking mothers.

Cited by 13 publications

References 40 publications

Identifying Sensitive Windows of Exposure to NO2 and Fetal Growth Trajectories in a Spanish Birth Cohort

Identifying Sensitive Windows of Exposure to NO2 and Fetal Growth Trajectories in a Spanish Birth Cohort

Identifying pre-conception and pre-natal periods in which ambient air pollution exposure affects fetal growth in the predominately Hispanic MADRES cohort

Effects of Maternal Environmental Exposure on Early Life Growth and Development

Contact Info

Product

Resources

About

Prenatal NO2exposure and ultrasound measures of foetal growth: a prospective cohort study in Wuhan, China

Abstract: In this prospective study of Chinese women, maternal NO exposure was inversely associated with foetal growth, and the association was stronger among female babies and smoking mothers.

Cited by 13 publications

References 40 publications

Identifying Sensitive Windows of Exposure to NO2 and Fetal Growth Trajectories in a Spanish Birth Cohort

Identifying Sensitive Windows of Exposure to NO2 and Fetal Growth Trajectories in a Spanish Birth Cohort

Identifying pre-conception and pre-natal periods in which ambient air pollution exposure affects fetal growth in the predominately Hispanic MADRES cohort

Effects of Maternal Environmental Exposure on Early Life Growth and Development

Contact Info

Product

Resources

About

Prenatal NO₂exposure and ultrasound measures of foetal growth: a prospective cohort study in Wuhan, China