Prenatal Nicotine and/or Cocaine Differentially Alters Nicotine‐Induced Sensitization in Aging Offspring

Sobrian, Sonya K.; Johnston, Malcolm C.; Wright, Jewel; Kuhn, Daniela; Ameis, Kamal

doi:10.1196/annals.1432.045

Cited by 7 publications

(10 citation statements)

References 65 publications

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“…Four studies report a blunting of the excitatory effect of nicotine challenge on activity due to low doses of prenatal nicotine exposure (Ankarberg et al 2001(Ankarberg et al , 2004Sobrian et al 2008), and two others report the opposite effects after high doses of prenatal exposure (Shacka et al 1997;Sobrian et al 2008). Interestingly, these studies either used only males (Ankarberg et al 2001(Ankarberg et al , 2004Eriksson et al 2000;Sobrian et al 2008) or found such effects in males but not females (Shacka et al 1997).…”

Section: Response To Drug Challengementioning

confidence: 88%

“…It should also be noted that these drug challenge studies were conducted mostly in adults; only one tested neonates (Shacka et al 1997), four tested adolescents (Abreu-Villaça et al 2004a; Pauly et al 2004;Seidler et al 1992, and eight tested adults (>PND 70; Ankarberg et al 2001Ankarberg et al , 2004Chistyakov et al 2010;Eriksson et al 2000;Fredriksson et al 2000;Sobrian et al 2003Sobrian et al , 2008Zbuzek and Chin 1994).…”

Section: Response To Drug Challengementioning

confidence: 97%

“…(B2) Ankarberg et al 2001Ankarberg et al , 2004Chistyakov et al 2010;Eriksson et al 2000;Franke et al 2007;Fredriksson et al 2000;Paulson et al 1993;Pauly et al 2004;Romero and Chen 2004. (B3) Ankarberg et al 2001Ankarberg et al , 2004Eriksson et al 2000;Fredriksson et al 2000;Martin and Martin 1981;Sobrian et al 2003Sobrian et al , 2008 (C1) Gilbertson and Barron 2005;King and Strand 1988;LeSage et al 2006;Schlumpf et al 1988. (C2) Huang et al 2007;Nordberg et al 1991;Romero and Chen 2004.…”

Section: Age At Testing (A) Increased (B) Not Affected (C) Decreasedmentioning

confidence: 98%

“…(A3) Newman et al 1999;Paz et al 2007;Peters et al 1979;Tizabi et al 2000. (B1) Franke et al 2007;Paulson et al 1993;Peters and Tang 1982;Schlumpf et al 1988;Shacka et al 1997;Sobrian et al 2003Sobrian et al , 2008. (B2) Ankarberg et al 2001Ankarberg et al , 2004Eriksson et al 2000;Fredriksson et al 2000;Frischer et al 1988;Gilbertson and Barron 2005;King and Strand 1988.…”

Section: Exposure Period (Species Combined) (A) Increased (B) Not Affmentioning

confidence: 98%

“…Thirteen studies assessed the effects of drug challenges (predominantly nicotine) on rats (7 studies) or mice (6) exposed to nicotine early in development (Abreu-Villaça et al 2004a;Ankarberg et al 2001Ankarberg et al , 2004Chistyakov et al 2010;Eriksson et al 2000;Fredriksson et al 2000;Pauly et al 2004;Seidler et al 1992;Shacka et al 1997;Slotkin et al 2006;Sobrian et al 2003Sobrian et al , 2008Zbuzek and Chin 1994). Six studies used only male offspring, another six used both sexes, and one did not specify the sex of animals.…”

Section: Response To Drug Challengementioning

confidence: 98%

See 4 more Smart Citations

Effects of Pre- and Neonatal Nicotine Exposure in Rodents: Inconsistent Evidence

Sobrian¹,

Holson²

2011

ILAR Journal

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This review presents an analysis of the literature on behavioral effects of developmental exposure to nicotine, as assessed in rodent models that mimic the consequences for human offspring of maternal cigarette smoking. Despite the frequency of reports of low birth weight, hyperactivity, cognitive deficits, and psychiatric problems, inconsistencies exist in both the clinical and experimental literature. Confounding socioeconomic and other demographic variables may account for discrepancies in clinical reports, and the choice of developmental exposure period and the method of nicotine administration may explain differences in experimental outcomes. Analysis of a number of variables (e.g., physical, behavioral, and cognitive) shows that fetal exposure to nicotine does not consistently cause growth retardation or decreased birth weight, nor reliably affect motor activity. But combined pre- and neonatal exposure is likely to result in delayed reflex development, global impairments in learning and memory, and an increased incidence of symptoms that model psychiatric illness. There is also support for increased self-administration of nicotine and other drugs of abuse in animals exposed developmentally to nicotine, as well as potent effects on offspring responses to drug challenges. Unlike reports in the clinical literature, sexually dimorphic effects were not evident in most animal models. Possible neuroanatomical and cholinergic mechanisms responsible for behavioral changes are briefly discussed. Statistical and design considerations are provided to increase the translational value of this research and, most importantly, enhance the replicability of reported findings.

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Section: Response To Drug Challengementioning

confidence: 88%

Section: Response To Drug Challengementioning

confidence: 97%

Section: Age At Testing (A) Increased (B) Not Affected (C) Decreasedmentioning

confidence: 98%

Section: Exposure Period (Species Combined) (A) Increased (B) Not Affmentioning

confidence: 98%

Section: Response To Drug Challengementioning

confidence: 98%

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Effects of Pre- and Neonatal Nicotine Exposure in Rodents: Inconsistent Evidence

Sobrian¹,

Holson²

2011

ILAR Journal

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Prenatal and postnatal cocaine exposure enhances the anxiety‐ and depression‐like behaviors in rats during cocaine withdrawal

Méndez,

Salazar‐Juárez

2024

Developmental Psychobiology

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Prenatal drug exposure is a public health problem, which results in profound behavioral problems during childhood and adolescence, mainly represented by an increase in the risk of cocaine abuse at an early age. In rodents, prenatal and postnatal cocaine exposure enhanced locomotor activity and cocaine‐ or nicotine‐induced locomotor sensitization. Various authors consider that the adverse emotional states (anxiety and depression) that occur during cocaine withdrawal are the main factors that precipitate, relapse, and increase chronic cocaine abuse, which could increase the risk of relapse of cocaine abuse. Therefore, the objective of this study was to characterize anxiety‐ and depression‐like behaviors at different times (30, 60, 90, and 120 days) of cocaine withdrawal in rats born to females exposed prenatally and postnatally to cocaine. A group of pregnant female Wistar rats were administered daily from day GD0 to GD21 with cocaine (cocaine preexposure group), and another group of pregnant female rats was administered daily with saline (saline preexposure group). Of the litters resulting from the cocaine‐pre‐exposed and saline‐pre‐exposed pregnant female groups, only the male rats were used for the recording of the anxiety‐ and depression‐like behaviors at different times (30, 60, 90, and 120 days) of cocaine withdrawal The study found that prenatal and postnatal cocaine exposure dose‐dependent enhanced anxiety‐ and depression‐like behaviors. This suggests that prenatal and postnatal cocaine exposure can result in enhanced vulnerability to cocaine abuse in young and adult humans.

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Repeated cocaine treatments induce distinct locomotor effects in Crayfish

Nathaniel¹,

Huber²,

Panksepp³

2012

Brain Research Bulletin

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Prenatal Nicotine and/or Cocaine Differentially Alters Nicotine‐Induced Sensitization in Aging Offspring

Cited by 7 publications

References 65 publications

Effects of Pre- and Neonatal Nicotine Exposure in Rodents: Inconsistent Evidence

Effects of Pre- and Neonatal Nicotine Exposure in Rodents: Inconsistent Evidence

Prenatal and postnatal cocaine exposure enhances the anxiety‐ and depression‐like behaviors in rats during cocaine withdrawal

Repeated cocaine treatments induce distinct locomotor effects in Crayfish

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