Prenatal morphine alters the synaptic complex of postsynaptic density 95 with N-methyl-d-aspartate receptor subunit in hippocampal CA1 subregion of rat offspring leading to long-term cognitive deficits

Granulocyte-Colony Stimulating Factor Alleviates Perinatal Hypoxia-Induced Decreases in Hippocampal Synaptic Efficacy and Neurogenesis in the Neonatal Rat Brain

“…The supernatants were combined and centrifuged at 11,000 g at 4°C for 20 min to obtain the synaptic P2 pellet. This synaptic pellet was then resuspended in 0.32 M sucrose containing phosphatise/protease inhibitor kit (Roche Molecular Biochemicals, Germany) (4,9,13,25). The protein concentrations were measured by the use of Bio-Rad DC protein-assay kits (Cat.…”

“…Studies indicated that transient cerebral hypoxia triggered a series of pathophysiological changes leading, ultimately, to the neurodegeneration in oxygen sensitive so-affected brain regions, including the hippocampus (an important integration area for mammalian cognitive learning and memory) (2)(3)(4). Although underlying mechanisms for the neonatal brain following perinatal hypoxia are extensively studied in the past, it remains unclear about synapse-basis pathogenesis and effective drug therapy.…”

Hyperbaric Oxygen Therapy Alleviates Carbon Monoxide Poisoning–Induced Delayed Memory Impairment by Preserving Brain-Derived Neurotrophic Factor–Dependent Hippocampal Neurogenesis

“…Cognitive function was evaluated by the use of eight-arm radial maze test, which includes two parts, maze adaptation followed by memory task, and was commenced in week 3 after CO poisoning alone or with additional treatments. Procedures of maze adaption were adopted from previous studies (28,29). The animals were food deprived to about 80% of their ad libitum body weight and trained for 9 consecutive days to run on an eight-arm radial maze (black Plexiglas, 60 × 3 × 10 cm arms extending from an octagonal central platform).…”

Environmental Chemical Substances in Relation to Neurodevelopmental Disorders: A Systematic Literature Review

“…This finding is the first time that multiple novel proteins that are dysregulated by B(a)P, which both enhance our understanding of B(a)P induced locomotor deficits and represent targets of novel therapeutics. Prenatal morphine can alter the synaptic complex of postsynaptic density 95 with N-methyl-D-aspartate receptor subunit in hippocampal CA1 subregion of rat offspring leading to long-term cognitive deficits (Lin et al 2009). This morphine model might be useful for understanding mechanisms of long-term cognitive deficit induced by other ECSs such as lead and PCBs.…”