Prenatal molybdenum exposure and infant neurodevelopment in Mexican children

Vázquez-Salas, Ruth Argelia; López‐Carrillo, Lizbeth; Menezes-Filho, José A.; Rothenberg, Stephen J.; Cebrián, Mariano E.; Schnaas, Lourdes; Viana, Gustavo Freitas de Souza; Torres‐Sánchez, Luisa

doi:10.1179/1476830513y.0000000076

Cited by 31 publications

(17 citation statements)

References 16 publications

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“…Mo is considered an essential trace element. Due to the small sample size of this study, the scarce evidence about its potential toxicity in humans, 13,15,16,35,36 further research with a larger sample size and a detail evaluation of other potential dietary and environmental sources of Mo is warranted.…”

Section: Resultsmentioning

confidence: 99%

“…However, in children from these women we observed a negative association between prenatal Mo exposure and infant psychomotor neurodevelopment. 16 Similarly, two studies have observed a possible association between Mo exposure with spermatic damage, 35 reproductive hormone alterations 36 and liver disorders 15 at BEs levels associated with toxicity in whole blood (0.45-22mg/L) or lower than those urinary BEs proposal levels for Mo.…”

Section: Discussionmentioning

confidence: 97%

“…From 517 confirmed pregnancies, there were 442 births and 353 of them began a neurodevelopment followup until five years of age. By financial limitation, the association between prenatal Mo exposure and infant neurodevelopment 16 was evaluated in a random sample of 147 children who had at least five neurodevelopment evaluations between 1-30 months of age and at least one maternal urine sample during pregnancy. Finally, for this report we only included 124 women who completed the food frequency questionnaire (FFQ) and also had provided at least two urine samples during their pregnancy.…”

Section: Study Populationmentioning

confidence: 99%

“…16 The objective of this study was to determine the dietary determinants of urinary Mo concentrations in this sample of pregnant women.…”

mentioning

confidence: 99%

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Dietary determinants of urinary molybdenum levels in Mexican women: a pilot study

Barrios¹,

Vázquez-Salas²,

López‐Carrillo³

et al. 2017

Salud Publica Mex

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Objective. This study determined the main dietary sources of urinary molybdenum (Mo) concentrations in a sample of 124 pregnant women in Mexico. Materials and methods. Dietary data was collected during pregnancy, through a semiqualitative food frequency questionnaire, with information of 84 foods. Urine Mo levels were determined by atomic absorption spectrometry, for at least two trimesters of pregnancy. The associations with Mo levels were estimated by generalized mixed effect regression models. Results. Between 5.8 to 12.7% of the samples were above the 95 th percentile of urinary Mo distribution reported by National Health and Nutrition Examination Survey (NHANES) 2009-2010 for women (151 μg/L and 148 μg/g creatinine). After bootstrap resampling was conducted, women with high-consumption of hot peppers (β=1.34μg/g; 95% CI: 1.00-1.80; p= 0.05) had marginally higher urinary Mo concentration levels, creatinine adjusted, compared to women with low-consumption. Conclusion. Hot chili pepper consumption may contribute to body burden Mo levels in this population.

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Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 97%

Section: Study Populationmentioning

confidence: 99%

“…16 The objective of this study was to determine the dietary determinants of urinary Mo concentrations in this sample of pregnant women.…”

mentioning

confidence: 99%

See 2 more Smart Citations

Dietary determinants of urinary molybdenum levels in Mexican women: a pilot study

Barrios¹,

Vázquez-Salas²,

López‐Carrillo³

et al. 2017

Salud Publica Mex

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“…Molybdenum is present in sulfite oxidase -an enzyme located in mitochondria that is responsible for amino acid and lipid metabolism (97). Little is known about the role of molybdenum in humans but it has been proposed that molybdenum has an association with neurodevelopment (98).…”

Section: Molybdenum (Mo)mentioning

confidence: 99%

Essential trace element analysis of human breast milk

Taufek¹,

Hidayah²

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Molybdenum

Klipsch

Aveyard²,

Carey

et al. 2023

Patty's Toxicology

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Molybdenum is an essential element for humans, animals, and plants. But excess exposure to molybdenum substances may cause harmful effects. This chapter describes natural occurrence, production, uses, and chemical and biochemical properties of molybdenum substances, and possible adverse effects in relation to dose. The emphasis is on commercial inorganic molybdenum substances and those where the molybdate ion [MoO 4 ] 2− is the driver for a biological effect.

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Prenatal molybdenum exposure and infant neurodevelopment in Mexican children

Abstract: As this is the first study that suggests a potential negative association between prenatal Mo exposure and infant neurodevelopment, these results require further confirmation.

Cited by 31 publications

References 16 publications

Dietary determinants of urinary molybdenum levels in Mexican women: a pilot study

Dietary determinants of urinary molybdenum levels in Mexican women: a pilot study

Essential trace element analysis of human breast milk

Molybdenum

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