Prenatal methylmercury exposure affects spatial vision in adult monkeys

Burbacher, Thomas M.; Grant, Kimberly S.; Mayfield, David; Gilbert, Steven G.; Rice, Deborah C.

doi:10.1016/j.taap.2005.01.011

Cited by 37 publications

(35 citation statements)

References 47 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The study intended to mimic the immunization schedule in human neonates. Corroborating Magos's et al (1985) conclusions in the rat experimental model, this study (Burbacher et al 2005) also reported that levels of organic mercury were lower in the brains of infant monkeys exposed to thimerosal compared to those exposed orally to MeHg. The brain half-times (defined as the time it takes for the brain level of mercury to decrease by half) also differed.…”

Section: Mercury Clears From the Body Much Faster After The Administrsupporting

confidence: 55%

“…Thus, ethylmercury appears to behave like MeHg with fecal excretion accounting for most of the elimination from the body. The absorption rate and initial distribution volume of total mercury are also reported to be generally similar after ethylmercury injections and oral MeHg exposure (Burbacher et al 2005). In other words, peak total blood mercury levels after a single exposure to either ethylmercury or MeHg are very similar, implying that the organic mercury compounds behave similarly in the early hours after exposure.…”

Section: Mercury Clears From the Body Much Faster After The Administrmentioning

confidence: 84%

“…The study concluded that at equimolar doses, MeHg exposure resulted in higher brain levels of the organic species than did treatment with ethylmercury (significance of the mercury species, namely organic versus inorganic, will be addressed below). In a second study, Burbacher et al (2005) reported on the disposition of mercury in infant monkeys intramuscularly injected with ethylmercury in the form of thimerosal in comparison with a second group of monkeys orally dosed with a MeHg compound. The study intended to mimic the immunization schedule in human neonates.…”

Section: Mercury Clears From the Body Much Faster After The Administrmentioning

confidence: 99%

See 2 more Smart Citations

Are Neuropathological Conditions Relevant to Ethylmercury Exposure?

Aschner

Ceccatelli

2009

Neurotox Res

View full text Add to dashboard Cite

Mercury and mercurial compounds are among the environmentally ubiquitous substances most toxic to both wildlife and humans. Once released into the environment from both natural and anthropogenic sources, mercury exists mainly as three different molecular species: elemental, inorganic, and organic. Potential health risks have been reported from exposure to all forms; however, of particular concern for human exposure relate to the potent neurotoxic effects of methylmercury (MeHg), especially for the developing nervous system. The general population is primarily exposed to MeHg by seafood consumption. In addition, some pharmaceuticals, including vaccines, have been, and some continue to be, a ubiquitous source of exposure to mercurials. A significant controversy has been whether the vaccine preservative ethylmercury thiosalicylate, commonly known as thimerosal, could cause the development of autism. In this review, we have discussed the hypothesis that exposure to thimerosal during childhood may be a primary cause of autism. The conclusion is that there are no reliable data indicating that administration of vaccines containing thimerosal is a primary cause of autism. However, one cannot rule out the possibility that the individual gene profile and/or gene-environment interactions may play a role in modulating the response to acquired risk by modifying the individual susceptibility.

show abstract

Section: Mercury Clears From the Body Much Faster After The Administrsupporting

confidence: 55%

Section: Mercury Clears From the Body Much Faster After The Administrmentioning

confidence: 84%

Section: Mercury Clears From the Body Much Faster After The Administrmentioning

confidence: 99%

See 1 more Smart Citation

Are Neuropathological Conditions Relevant to Ethylmercury Exposure?

Aschner

Ceccatelli

2009

Neurotox Res

View full text Add to dashboard Cite

show abstract

“…Studies in monkeys showed that developmental as well as post-natal MeHg exposure could accelerate the impairment in auditory functions observed with ageing (Rice 1998;Rice and Gilbert 1992). Prenatal MeHg exposure has also shown to affect visual contrast sensitivity in adult monkeys (Burbacher et al 2005). In a review of the contribution of animal studies to the understanding the neurodevelopmental toxicity of MeHg, Castoldi et al suggest that there is a need to include the ''quality of aging'' as an additional endpoint in toxicity studies on MeHg (Castoldi et al 2008).…”

Section: Discussionmentioning

confidence: 99%

Neurotoxic Sequelae of Mercury Exposure: An Intervention and Follow-up Study in the Brazilian Amazon

et al. 2011

View full text Add to dashboard Cite

Since 1995, the Caruso Project used an Ecosystem Approach to Human Health to examine mercury (Hg) exposure in fish-eating communities in the Brazilian Amazon and develop interventions to maximise nutrition from traditional diet and minimise toxic risk. In 1995, 2000 and 2006, this study followed fish consumption, Hg levels, and visual and motor functions in 31 villagers. Questionnaires gathered information on socio-demographics and diet. Hair Hg (H-Hg) levels were measured. Visual acuity, colour vision, manual dexterity and grip strength were assessed. Data was analysed using general linear models of repeated measures. Total fish consumption, similar in 1995 and 2000, decreased in 2006. Carnivorous fish consumption initially decreased and then remained stable, whereas non-carnivorous fish consumption first increased and then decreased. H-Hg declined from 17.6 to 7.8 μg/g. Visual functions showed a significant decrease over time, with those with H-Hg ≥ 20 μg/g in 1995 showing greater loss. Motor functions showed initial improvement and then returned to the 1995 performance level. Decrease in Hg exposure is attributed to the intervention and socio-economic changes in the village. While there may be a certain reversibility of motor deficits, visual capacities may decrease progressively with respect to exposure prior to the intervention.

show abstract

“…Quando a exposição ocorre durante o desenvolvimento embrionário, os prejuízos nas funções visuais espaciais tornam-se permanentes na idade adulta (Burbacher, Grant, Mayfield, Gilbert, & Rice, 2005).…”

Section: Mercúrio No Sistema Visualunclassified

Estudo eletrofisiológico e psicofísico em indivíduos intoxicados por vapor de mercúrio

Barboni¹

View full text Add to dashboard Cite

show abstract

Prenatal methylmercury exposure affects spatial vision in adult monkeys

Cited by 37 publications

References 47 publications

Are Neuropathological Conditions Relevant to Ethylmercury Exposure?

Are Neuropathological Conditions Relevant to Ethylmercury Exposure?

Neurotoxic Sequelae of Mercury Exposure: An Intervention and Follow-up Study in the Brazilian Amazon

Estudo eletrofisiológico e psicofísico em indivíduos intoxicados por vapor de mercúrio

Contact Info

Product

Resources

About