Prenatal Methotrexate Exposure Decreases Seizure Susceptibility in Young Rats of Two Strains

Kábová, Radka; Velı́šková, Jana; Velı́šek, Libor

doi:10.1006/exnr.1999.7318

Cited by 10 publications

(2 citation statements)

References 43 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…administered on E15, the offspring invariably demonstrated increased resistance to evoked seizures, i.e., this exposure had anticonvulsant features. 50 Similarly, there was an increased resistance to low Mg 2+ -induced epileptiform activity in slices from prenatally MTX-exposed rats. 51 There was no sex difference in these effects of prenatal MTX.…”

Section: Examples Of Models Of Prenatal Drug Exposurementioning

confidence: 92%

“…Methotrexate (MTX, amethopterin), a folic acid antimetabolite, disrupts DNA synthesis during the S phase 47–49 . If a single dose of 5 mg/kg was administered on E15, the offspring invariably demonstrated increased resistance to evoked seizures, i.e., this exposure had anticonvulsant features 50 . Similarly, there was an increased resistance to low Mg 2+ ‐induced epileptiform activity in slices from prenatally MTX‐exposed rats 51 .…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

CNS Aspects of Prenatal Drug Exposure

Velı́šek

2006

Annals of the New York Academy of Sciences

View full text Add to dashboard Cite

Studies of the effects of prenatal exposure (to drugs or environmental factors) on postnatal brain morphology and function have an important role in assessing adverse effects of prenatal administration of corticosteroids in obstetrics, in studying the impairment of the offspring due to maternal drug abuse, as well as in studies of the influence of other environmental factors (such as toxins or stress). Timing, duration, and dose of the prenatal exposure play a significant role in the postnatal expression of the impact. However, data interpretation may be complicated by additional factors. As mixed litters of prenatally exposed subjects are evaluated, significant differences between males and females may occur. Additionally in females, cyclical changes in ovarian steroids may interfere with the effects of prenatal impact. Developmental differences may be also present, and data from infant, juvenile, prepubertal, and adult individuals cannot be simply compared. Finally, prenatal treatment is a stressful event and may present itself as prenatal stress, misguiding the interpretation. Postnatal environmental factors in raising the offspring, such as housing, maternal care, light-dark cycle, and weaning age can also change the data in such a way, which makes comparisons between different research laboratories impossible.

show abstract

Section: Examples Of Models Of Prenatal Drug Exposurementioning

confidence: 92%