Prenatal methamphetamine exposure affects the mesolimbic dopaminergic system and behavior in adult offspring

Bubeníková-Valešová, Věra; Kačer, Petr; Syslová, Kamila; Rambousek, Lukáš; Janovský, Martin; Schutová, Barbora; Hrubá, Lenka; Šlamberová, Romana

doi:10.1016/j.ijdevneu.2009.06.012

Cited by 71 publications

(41 citation statements)

References 29 publications

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“…There were also no differences in exploratory activity in the EPM of either group in our previous work (Pometlová et al, 2008). These results are in agreement with findings showing increased activity only in animals with prenatal application of MA but not in controls in the open field test (Bubenikova-Valesova et al, 2009). However, in the test of social interaction there was increase of locomotion after single low-dose MA application (Pometlová et al, 2007;Slamberova et al, 2010).…”

Section: )supporting

confidence: 88%

Anxiogenic Effect of Low-dose Methamphetamine in the Test of Elevated Plus-maze

2012

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R e c e i ve d Fe b r u a r y 2 3 , 2 0 1 2 ; A c c e p t e d Ju n e 2 5 , 2 0 1 2 .Key words: Anxiety -Behavior -Elevated plus-maze -Methamphetamine Abstract: Methamphetamines (MA) are psychostimulant drugs that are known to change individuals' behavior. Psychostimulants could either evoke positive emotions (e.g. joy and happiness) or attenuate negative emotional states (e.g. anxiety and depression) in humans. In animal experiments, the test of elevated plus-maze (EPM) is widely used. This test is appropriate for evaluation of anxiolytic and anxiogenic drug effects, or for examination of specific subtypes of anxiety disorders. The aim of the present study was to examine the effect of acute single dose of MA (1 mg/kg) on the behavior of laboratory rat in the EPM. The detailed ethologic analysis of behavior was performed using a modified protocol based on the study of Fernández Espejo (1997). Our results demonstrated that MA affects rat's behavior in the EPM in the majority of analyzed categories. The present protocol allowed us to determine positive anxiogenic effect of MA.

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confidence: 88%

Anxiogenic Effect of Low-dose Methamphetamine in the Test of Elevated Plus-maze

2012

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“…Also our previous studies demonstrated that prenatal MA exposure induces changes in the mesolimbic dopaminergic system, which results in changes in behaviour that is associated especially with sensorimotor development (Šlamberová et al, 2006;Bubeníková-Valešová et al, 2009). Furthermore, we demonstrated that prenatally MA-exposed offspring are more sensitive to MA in adulthood (Schutová et al, 2009a.…”

Section: Introductionmentioning

confidence: 71%

“…MA affects the dopamine levels in the nucleus accumbens. The basal levels of dopamine is in offspring of MA treated mothers higher by about 300% and in case of administration of acute dose of MA dopamine levels elevated by about 1,000%, the difference between MA group and control group was 35% (Bubeníková-Valešová et al, 2009).…”

Section: Discussionmentioning

confidence: 91%

“…The fact that the abuse of MA among pregnant women rises worldwide may cause health problems of pregnant women and may result in developmental impairments of their children (Plessinger, 1998). Even though the exact mechanisms of action of amphetamines are still not fully explained, it had been shown that they can cross both placental and bloodbrain barriers (Bubeníková-Valešová et al, 2009). Arising evidence suggests that prenatal MA exposure influences a growth of foetus and may lead to a variety of developmental, behavioural, and neurological abnormalities (Kwiatkowski et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

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The Effect of Prenatal Methamphetamine Exposure on Recognition Memory in Adult Rats

Fialová¹,

Šírová²,

Bubeníková-Valešová³

et al. 2015

Prague Med. Rep.

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Abstract:The use of methamphetamine (MA) among pregnant women is an increasing world-wide health problem. Prenatal MA exposure may cause changes in foetus but the exact effects have remained unclear. The aim of this study is to present the effect of prenatal MA exposure on recognition memory in adult rats. Adult female Wistar rats were injected daily with D-methamphetamine HCl (MA; 5 mg/kg, s.c.) during the entire gestation period. Control females were treated with saline in the same regime. Adult male offspring was administrated acutely by MA (1 mg/kg i.p.) or saline 30 minutes before beginning of an experiment. For testing recognition memory two tasks were chosen: Novel Object Recognition Test (NORT) and Object Location Test (OLT). Our results demonstrate that prenatally MA-exposed animals were worse in NORT independently on an acute administration of MA in adulthood. Prenatally MA-exposed rats did not deteriorate in OLT, but after acute administration of MA in adulthood, there was significant Prague Medical Report / Vol. 116 (2015) No. 1, p. 31-39 worsening compared to appropriate control. Prenatally saline-exposed offspring did not deteriorate in any test even after acute administration of MA. Our data suggest that prenatal MA exposure in rats cause impairment in recognition memory in adult offspring, but not in spatial memory. In addition, acute administration of MA to controls did not deteriorate either recognition or spatial memory. 32)

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“…Further, we found that prenatal MA exposure with respect of adult MA challenge impairs the learning abilities tested in Morris water maze (Schutová et al, 2008), affects anxiety behavior , alters pain sensitivity in Plantar tests in sex-specific manner (Yamamotová et al, 2011) and seizure susceptibility in adult male and female rats Bernášková et al, 2011). In our most recent studies we demonstrated that there is a sensitizing effect of prenatal MA exposure to the same drug in adulthood (Bubeníková-Valešová et al, 2009;Šlamberová et al, 2011a, b).…”

Section: Introductionmentioning

confidence: 56%

Does Prenatal Methamphetamine Exposure Induce Cross-sensitization to Cocaine and Morphine in Adult Male Rats?

et al. 2012

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R e c e i ve d J a n u a r y 2 3 , 2 0 12 ; A c c e p t e d Ju n e 2 5 , 2 0 1 2 .Key words: Prenatal drug exposure -Methamphetamine -Cocaine -MorphineOpen field -Plantar test -Conditioned place preference -LocomotionNociception -Drug-seeking behavior Abstract:The aim of the present study was to examine the cross-sensitization induced by prenatal methamphetamine (MA) exposure to challenge dose of cocaine or morphine. Rat mothers received a daily injection of MA (5 mg/kg) or saline throughout the gestation period. Adult male offspring (prenatally MA-or saline-exposed) were divided to groups with challenge doses of saline (1 ml/kg), cocaine (5 mg/kg) or morphine (5 mg/kg). Behavior in unknown environment was examined in Laboras, nociception in Plantar test, and active drug-seeking behavior in conditioned place preference (CPP). Our data demonstrate that cocaine increased the exploratory activity in Laboras test in prenatally saline-exposed, but decreased it in prenatally MA-exposed rats. An analgesic effect of cocaine was demonstrated only by the tail withdrawal and it was independent of the prenatal drug exposure. CPP test showed that prenatal MA exposure induced rather tolerance than sensitization to cocaine. In contrast to cocaine effects, morphine decreased rearing activity in both, prenatally MA-exposed and saline-exposed rats, and locomotion only in prenatally MA-exposed rats in the Laboras. In the Plantar Prague Medical Report / Vol. 113 (2012) No. 3, p. 189-205 test, the results demonstrated that morphine had an analgesic effect in prenatally saline-exposed rats but this effect was suppressed in prenatally MA-exposed rats. In the CPP test morphine induced drug-seeking behavior, which however was not affected by prenatal drug exposure. Thus, our data demonstrate that there is a cross-effect between prenatal MA exposure and the challenge dose of other drug in adulthood, however drug-seeking behavior is not increased by prenatal MA exposure as we expected.

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Prenatal methamphetamine exposure affects the mesolimbic dopaminergic system and behavior in adult offspring

Cited by 71 publications

References 29 publications

Anxiogenic Effect of Low-dose Methamphetamine in the Test of Elevated Plus-maze

Anxiogenic Effect of Low-dose Methamphetamine in the Test of Elevated Plus-maze

The Effect of Prenatal Methamphetamine Exposure on Recognition Memory in Adult Rats

Does Prenatal Methamphetamine Exposure Induce Cross-sensitization to Cocaine and Morphine in Adult Male Rats?

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