Prenatal maternal anxiety related with dietary pattern may promote atopic dermatitis in offspring through the alteration of gut microbiota

Abstract

Abstracts AB133SUNDAY

Maternal exposures and the infant gut microbiome: a systematic review with meta-analysis

“…141 In a very large sample (n = 1,681) of four-month-old infants from the CHILD birth cohort, 142 infants of mothers with prenatal depressive symptoms, with or without antidepressant treatment, had higher median abundance of Lachnospiraceae in their gut compared to infants of mothers with few depressive symptoms, which was modified by prenatal pet ownership (P interaction = 0.02). Lee and colleagues 144 similarly reported that whilst infants of mothers with high anxiety scores had different Escherichia, Bacteroides, Clostridium , and Terrisporobacter profiles compared to controls (data not shown), this was modified by a healthy maternal diet pattern (defined by a high intake of vegetables and fruit). Maternal prenatal reported stress and cortisol levels were also found to be significantly associated with total microbiota composition (P < 0.01) in Zijlmans et al .…”

“…The relationship between maternal depression, anxiety or stress and the infant intestinal microbiome was explored by four observational studies . [141][142][143][144] Maternal mood disorders were associated with changes in the infant gut microbiome; however, these were often modified by time and other environmental factors. Oneweek-old infants whose mothers had high depressive scores during pregnancy were associated with a lower e1897210-14 abundance of Actinobacteria and a higher abundance of Proteobacteria compared to controls, although this difference did not persist over time .…”

“…Six abstracts (8%) also did not provide sufficient detail in order to warrant quality assessment. 112,121,139,141,144,151…”

The skin microbiome in the first year of life and its association with atopic dermatitis

“…However, it is not clear whether the skin microbiome was impacting the skin barrier function, or whether a common causal factor exists which increases the risk of CS delivery while also affecting the newborn's skin barrier, independently of the skin microbiome. This may involve parental factors such as metabolic diseases and anxiety as well as genetic, environmental, and life‐style factors that may affect both mothers and children 47–49 …”