Prenatal management of fetal goiter alternating between hypothyroidism and hyperthyroidism in a mother with Graves’ disease

Didier‐Mathon, Hortense; Bouchghoul, Hanane; Sénat, Marie-Victoire; Young, Jacques; Luton, Dominique

doi:10.1002/ccr3.4012

Cited by 7 publications

(4 citation statements)

References 12 publications

(14 reference statements)

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Hipertiroidisme janin dapat menyebabkan fetal growth restriction (FGR) yang disertai dengan pematangan tulang yang dipercepat, perkembangan goiter, dan craniosynostosis. 19 Ditemukannya fetal goiter pada USG memerlukan diagnosis yang tepat sebelum pengenalan pengobatan apa pun. Fetal goiter dapat dikaitkan dengan hipotiroidisme, hipertiroidisme, atau keadaan eutiroidisme yang lebih jarang.…”

Section: Gambar 1 Hasil Pemeriksaan Pada 27unclassified

Penanganan Kasus Kehamilan 32 Minggu dengan Hipertiroid Janin-Fetal Goiter

Albernande,

Sutrisno,

Lestari

et al. 2024

Obgynia

View full text Add to dashboard Cite

Hipertiroid pada kehamilan didefinisikan sebagai peningkatan kadar free T4. Hipertiroid terjadi pada 2/1000 kehamilan yaitu hipertiroid yang tidak terkontrol selama kehamilan meningkatkan risiko krisis tiroid, kelahiran prematur, dan kematian janin. Pasien Ny. DK 21 tahun datang dengan keluhan benjolan di leher kanan sebesar telur puyuh, hamil 21 minggu, dengan hasil USG fetal goiter. Pemeriksaan fisik didapatkan keadaan umum baik, suhu 36,6 0 C; tekanan darah: 120/80 mmHg; frek. nadi: 92x/menit; frek. nafas: 20 x/menit. Pada pemeriksaan Leopold I didapatkan tinggi fundus uteri 21 cm, teraba bagian lunak. Leopold II teraba tahanan memanjang di sisi kiri kesan punggung. Leopold III teraba bagian terbawah bulat, melenting dan keras U 5/5, kesan kepala. DJJ 159x/ mnt, TBJ 1240 gram. Pada pasien dilakukan observasi dan kontrol dengan rentang 2 minggu setelah pemeriksaan. Tata laksana pada pasien ini adalah asam folat, kalsium karbonat, vitamin D, propylthiouracil, folamil, dan ferrous sulfat.

show abstract

Section: Gambar 1 Hasil Pemeriksaan Pada 27unclassified

Penanganan Kasus Kehamilan 32 Minggu dengan Hipertiroid Janin-Fetal Goiter

Albernande,

Sutrisno,

Lestari

et al. 2024

Obgynia

View full text Add to dashboard Cite

show abstract

“…However, a goiter can rarely also be caused by fetal hypothyroidism. Therefore, performing cordocentesis is the diagnostic key [ 2 ]. Antithyroid drugs are the therapy of choice, with PTU being the preferred medication as it causes less fetotoxicity [ 1 ].…”

Section: Descriptionmentioning

confidence: 99%

Fetal thyrotoxicosis after total thyroidectomy due to Graves’ disease

Reineke

Gembruch

Geipel

2023

Arch Gynecol Obstet

View full text Add to dashboard Cite

“…ATD therapy rarely causes foetal goitre, with tracheal and oesophageal compression, polyhydramnios, and complications at delivery, 23 and only if maternal FT4 is not maintained in the high‐normal range.…”

Section: What Are the Treatment Options For Gd In Pregnancy?mentioning

confidence: 99%

How to manage Graves’ disease in women of childbearing potential

Ashkar

Sztal‐Mazer

Topliss

2022

Clinical Endocrinology

View full text Add to dashboard Cite

The management of Graves’ disease (GD) in women of childbearing potential has multiple specific complexities. Many factors are involved, which differ at the various stages from preconception, conception, first trimester, later pregnancy, postpartum and lactation, with both maternal and foetal considerations. The incidence and significance of the risks incurred from antithyroid drugs (ATDs) in pregnancy have been re‐evaluated recently and must be balanced against the risks of uncontrolled hyperthyroidism during childbearing years. Contraception is advised until hyperthyroidism is controlled. ATD cessation should be considered in those who are well controlled on low dose therapy before conception and in early pregnancy. Advice on iodine supplementation does not generally differ in those with GD. Radioiodine (RAI) is contraindicated from 6 months preconception until completion of breastfeeding. In all women who have a history of GD, monitoring of TSH receptor antibodies (TRAb) is strongly recommended during pregnancy, and if elevated, foetal monitoring and assessment of thyroid function in the neonate are required. Of note, RAI increases TRAb for up to a year, making this treatment option even less attractive in this patient group. A small amount of ATD is transferred into breast milk but low doses are safe during lactation. Routine periodic thyroid function testing is recommended in remission to detect postpartum GD recurrence. We present our approach to the Clinical Question ‘How to manage GD in women of childbearing potential?’

show abstract

Prenatal management of fetal goiter alternating between hypothyroidism and hyperthyroidism in a mother with Graves’ disease

Cited by 7 publications

References 12 publications

Penanganan Kasus Kehamilan 32 Minggu dengan Hipertiroid Janin-Fetal Goiter

Penanganan Kasus Kehamilan 32 Minggu dengan Hipertiroid Janin-Fetal Goiter

Fetal thyrotoxicosis after total thyroidectomy due to Graves’ disease

How to manage Graves’ disease in women of childbearing potential

Contact Info

Product

Resources

About