Prenatal LPS induces sickness behaviour and decreases maternal and predatory behaviours after an LPS challenge

Mendes-Lima, T.; Kirsten, Thiago Berti; Rodrigues, P.; Sampaio, Ana Claudia Silva; Felício, Luciano Freitas; Rocha, P.R.D.; Reis-Silva, Thiago Marinho; Bondan, Eduardo Fernandes; Martins, M.F.; Queiroz‐Hazarbassanov, Nicolle; Bernardi, Maria Martha

doi:10.1080/00207454.2019.1706505

Cited by 6 publications

(5 citation statements)

References 57 publications

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“…According to (Mendes-Lima et al, 2020), "Sick behavior" typically refers to actions or behaviors that are indicative of someone experiencing illness or poor health, whether physical or mental. It can encompass a range of behaviors depending on the context and the type of illness involved.…”

Section: Discussionmentioning

confidence: 99%

The Urgency of Stunting Policy Management Based on Local Knowledge in Malang Regency

Kurniawan,

Maksum,

Al-Yusainy

et al. 2024

LOGOS

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In the Malang Regency region, the issue of stunting is pressing. According to statistics showing the high rate of stunting in Malang Regency, a stunting management strategy must be put into place right away. To date, the issue has been whether policies at the upstream level address all the factors necessary to combat stunting. This study talks about how urgent municipal policies are, particularly for managing stunting. It should be mentioned that government policies currently in place are focused on improving and regulating food security, food quality, and program socialization. Additionally, both targeted and delicate treatments are a manifestation of the prevention of stunting. The heath industry performs specific interventions. The phenomenology of Malang Regency's stunting prevention strategies is revealed by this study. According to the study's findings, there are a number of issues that require immediate attention, particularly those that are local in nature, like local education on the marriage readiness index, particularly in areas with a high incidence of young marriage, like Tajinan sub-district. The health sector, as well as other connected sectors, must be involved in the regional follow-up to the village level of policies and regulations that are in place at the federal level. Due to the community's increased knowledge of the value of a balanced diet and the readiness of parents at marriageable age, the community-based coping system needs to be improved once more. Localized coping strategies will undoubtedly.

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Section: Discussionmentioning

confidence: 99%

The Urgency of Stunting Policy Management Based on Local Knowledge in Malang Regency

Kurniawan,

Maksum,

Al-Yusainy

et al. 2024

LOGOS

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“…Increased anxiety-like and depressive-like behavior after LPS administration have been reported in mice [20][21][22][23] and rats [24][25][26][27][28][29]. In these works, a decrease in locomotor activity, food intake, social interaction, and/or exploration for novel objects was observed in rodents several hours after the endotoxin insult.…”

Section: Introductionmentioning

confidence: 92%

Antibiotic-induced dysbiosis does not potentiate the effect of lipopolysaccharide insult in male Wistar rats

Tejkalová

Jakob

Kvasnová

et al. 2022

Preprint

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The present study investigated whether neonatal exposure to the proinflammatory endotoxin lipopolysaccharide (LPS) followed by antibiotic (ATB)-induced dysbiosis in early adulthood could induce schizophrenia-like behavioral changes in adult male rats. The combination of these two stressors resulted in decreased weight gain, but no significant behavioral abnormalities were observed. LPS treatment resulted in adult rats hypoactivity and induced anxiety-like behavior in the social recognition paradigm, but these behavioral changes were not exacerbated by ATB-induced gut dysbiosis. ATB treatment seriously disrupted the gut bacterial community, but dysbiosis did not affect locomotor activity, social recognition, and acoustic reactivity in adult rats. Fecal bacterial community analyzes showed no differences between the LPS challenge exposed/unexposed rats, while the effect of ATB administration was decisive regardless of prior LPS exposure. ATB treatment resulted in significantly decreased bacterial diversity, suppression of Clostridiales and Bacteroidales, and increases in Lactobacillales, Enterobacteriales, and Burkholderiales. The persistent effect of LPS on some aspects of behavior suggests a long-term effect of early toxin exposure that was not observed in ATB-treated animals. However, an anti-inflammatory protective effect of ATB cannot be assumed because of the increased abundance of pro-inflammatory, potentially pathogenic bacteria (Proteus, Suttrella) and the elimination of the bacterial families Ruminococcaceae and Lachnospiraceae, which are generally considered beneficial for gut health.

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“…It is now well established that the brain responds to changes in peripheral inflammation [14][15][16]. The most intuitive example is sickness behavior, in which physiological and behavioral processes, including sleep, appetite, mood, and cognition, are altered during inflammation or infection [32][33][34][35][36]. All of these functions are regulated by the brain, specifically by neuronal networks that were shown to be affected, at least in part, by cytokines [32][33][34][35][36].…”

Section: Evidence For the Involvement Of The Insular Cortex In Immune...mentioning

confidence: 99%

“…The most intuitive example is sickness behavior, in which physiological and behavioral processes, including sleep, appetite, mood, and cognition, are altered during inflammation or infection [32][33][34][35][36]. All of these functions are regulated by the brain, specifically by neuronal networks that were shown to be affected, at least in part, by cytokines [32][33][34][35][36]. The specific involvement of the IC in peripheral inflammation has been demonstrated through several lines of evidence: (1) imaging and activity mapping, (2) functional studies, and (3) anatomical evidence for connections between the IC and peripheral immune organs.…”

Section: Evidence For the Involvement Of The Insular Cortex In Immune...mentioning

confidence: 99%

Immunoception: the insular cortex perspective

Rolls

2023

Cell Mol Immunol

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To define the systemic neuroimmune interactions in health and disease, we recently suggested immunoception as a term that refers to the existence of bidirectional functional loops between the brain and the immune system. This concept suggests that the brain constantly monitors changes in immune activity and, in turn, can regulate the immune system to generate a physiologically synchronized response. Therefore, the brain has to represent information regarding the state of the immune system, which can occure in multiple ways. One such representation is an immunengram, a trace that is partially stored by neurons and partially by the local tissue. This review will discuss our current understanding of immunoception and immunengrams, focusing on their manifestation in a specific brain region, the insular cortex (IC).

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Prenatal LPS induces sickness behaviour and decreases maternal and predatory behaviours after an LPS challenge

Abstract: Supplementary table 2. Statistical data of predatory behavior. The parameters evaluated by the time were analyzed by the 2-way ANOVA; the frequencies and latencies were analyzed by the one-way ANOVA or the Kruskal-Wallis test.

Cited by 6 publications

References 57 publications

The Urgency of Stunting Policy Management Based on Local Knowledge in Malang Regency

The Urgency of Stunting Policy Management Based on Local Knowledge in Malang Regency

Antibiotic-induced dysbiosis does not potentiate the effect of lipopolysaccharide insult in male Wistar rats

Immunoception: the insular cortex perspective

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