Prenatal Loss of Father and Psychiatric Disorders

Huttunen, Matti

doi:10.1001/archpsyc.1978.01770280039004

Cited by 312 publications

(150 citation statements)

References 14 publications

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“…Again, in those individuals conceived at the peak of the famine showed an increased risk of schizophrenia and other conditions. Increased incidence of schizophrenia in the offspring of stressed mothers has also been reported by Huttenen et al 36 , Kinney et al 37 , and others.…”

Section: Behavioral and Psychological Problemssupporting

confidence: 58%

Os efeitos do estresse na função do eixo hipotalâmico-pituitário-adrenal em indivíduos com esquizofrenia

Guest

Martins-de-Souza²,

Rahmoune

et al. 2012

Arch. Clin. Psychiatry (São Paulo)

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Over the last few decades, evidence has been emerging that the pathogenesis of psychiatric disorders such as schizophrenia can involve perturbations of the hypothalamic-pituitary-adrenal (HPA) axis. Variations in the manifestation of these effects could be related to the differences in clinical symptoms between affected individuals as well as to differences in treatment response. Such effects can also arise from the complex interaction between genes and environmental factors. Here, we review the effects of maternal stress on abnormalities in HPA axis regulation and the development of psychiatric disorders including schizophrenia. Studies in this area may prove critical for increasing our understanding of the multi-dimensional nature of schizophrenia. Further research in this area could ultimately lead to the development of improved diagnostics and novel therapeutic approaches for treating this debilitating psychiatric condition.Guest FL, et al. / Rev Psiq Clín. 2013;40(1):20-7 Keywords: Psychiatric disorders, schizophrenia, HPA axis dysfunction, diagnosis, biomarkers. ResumoNas últimas décadas, têm surgido evidências sugerindo que a patogênese de desordens psiquiátricas, tais como a esquizofrenia, pode envolver perturbações no eixo hipotalâmico-pituitário-adrenal (HPA). Variações na manifestação desses efeitos poderiam estar relacionadas a diferenças em sintomas clínicos entre os indivíduos afetados, assim como a diferenças na resposta ao tratamento. Tais efeitos podem também ser originados de complexas interações entre genes e fatores ambientais. Aqui, revisamos os efeitos do estresse maternal em anormalidades na regulação do eixo HPA e desenvolvimento de desordens psiquiátricas, incluindo a esquizofrenia. Estudos nessa área podem gerar o aumento do nosso entendimento da natureza multidimensional da esquizofrenia. Posterior pesquisa nesse campo poderia, em última instância, levar ao desenvolvimento de melhores diagnósticos e novas abordagens terapêuticas para essa debilitante condição psiquiátrica.Guest FL, et al. / Rev Psiq Clín. 2013;40(1):20-7 Palavras-chave: Desordens psiquiátricas, esquizofrenia, disfunção do eixo HPA, diagnóstico, biomarcadores.

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Section: Behavioral and Psychological Problemssupporting

confidence: 58%

Os efeitos do estresse na função do eixo hipotalâmico-pituitário-adrenal em indivíduos com esquizofrenia

Guest

Martins-de-Souza²,

Rahmoune

et al. 2012

Arch. Clin. Psychiatry (São Paulo)

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“…This partially replicates the classic finding of Huttunen and Niskanen. 31 This study showed that those whose fathers had died during their fetal period were at an increased risk of schizophrenia compared with those whose fathers had died during early childhood. This epidemiological evidence has been supported by recent animal work linking prenatal stress and impaired behavioral adjustment/ emotional reactivity in the offspring.…”

Section: Prenatal Stressmentioning

confidence: 76%

“…The prenatal stress/schizophrenia association has been examined in several different ways. Death of spouse 31,32 and experience of catastrophic events, such as war 33 and nuclear explosion, 34 have been found to increase the risk of schizophrenia among those exposed. van Os and Selten 33 found an increased relative risk (RR) of schizophrenia (RR 1.28) among those in the Netherlands who were in their first or second trimester during the Nazi invasion in May 1940, and Malaspina and colleagues 35 found that those in their second month of gestation during the 1967 Arab-Israel War (Six-Day War) also had an increased risk of schizophrenia.…”

Section: Prenatal Stressmentioning

confidence: 99%

Predicting Risk and the Emergence of Schizophrenia

Clarke

Kelleher

Clancy

et al. 2012

Psychiatric Clinics of North America

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“…As early as in 1978 Huttunen et al introduced the idea of using the loss of a close relative to test the effect of prenatal stress on fetal brain development (12). Other have shown that maternal anxiety or depression during pregnancy was associated with behavioural/emotional problems in the offspring (14;15).…”

Section: Discussionmentioning

confidence: 99%

Attention-deficit/hyperactivity disorder in the offspring following prenatal maternal bereavement: a nationwide follow-up study in Denmark

Olsen

Vestergaard

et al. 2010

Eur Child Adolesc Psychiatry

170

131

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Severe prenatal stress exposure has been found to increase the risk of neuropsychiatric conditions like schizophrenia. We examined the risk of Attention-deficit/hyperactivity disorder (ADHD) in the offspring following prenatal maternal bereavement, as a potential source of stress exposure. We conducted a nationwide population-based cohort study including all 1 015 912 singletons born in Denmark from 1987 to 2001. A total of 29 094 children were born to women who lost a close relative during pregnancy or up to one year before pregnancy. These children were included in the exposed cohort and other children were in the unexposed cohort. We used Cox regression to estimate hazard ratios for ADHD, defined as the first-time ADHD hospitalization or first-time ADHD medication after 3 years of age. Boys born to mothers who were bereaved by unexpected death of a child or a spouse, had a 72% increased risk of ADHD (Hazard ratio [HR]=1.72, 95% confidence interval [CI]=1.09-2.73). Boys born to mothers who lost a child or a spouse during 0-6 months before pregnancy and during pregnancy had a HR of 1.47 (95%CI=1.00-2.16) and 2.10 (95% CI =1.16-3.80), respectively. Our findings suggest that prenatal maternal exposure to severe stress may increase the risk of ADHD in the offspring.Key words Attention-deficit/hyperactivity Disorder (ADHD); stress; bereavement; fetal programming; child psychiatry.Ms No. ECAP-D-09-00192R2, Prenatal stress and ADHD, 04042010 3, LiAttention deficit hyperactivity disorder (ADHD) is one of the most common childhood psychiatric disorders (1;2). This disease causes a number of adverse academic and vocational conditions in children, and exerts stress to the affected families and economic burden on society (3). The disorder has a substantial genetic component but epidemiological studies suggest that environmental factors operating in early life most likely contribute to the disease risk (3-5). Evidence from animal studies suggests that maternal stress during pregnancy may affect fetal neurodevelopment (6;7). One of the underlying mechanisms is termed as 'fetal programming', which occurs when the normal pattern of fetal development is disrupted by an abnormal stimulus or insult at critical time points (6;8). Excessive glucocorticoids following stress in pregnant mothers may have such a programming effect on brain development (6-9). In epidemiological studies, prenatal stress has been linked to congenital malformations (10), cerebral palsy (11), and psychiatric disorders including schizophrenia(12;13). Anxiety during pregnancy has been associated with ADHD phenotypical behavior in the offspring (14;15) but no published studies have evaluated the association between prenatal stress and the risk of ADHD.We hypothesized that prenatal stress had a programming effect on brain development (16-18) and could increase the risk of ADHD in childhood. We examined this hypothesis in a cohort study based on data from several nationwide registers in Denmark.Bereavement is a severe life event known to induce stress (...

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Prenatal Loss of Father and Psychiatric Disorders

Cited by 312 publications

References 14 publications

Os efeitos do estresse na função do eixo hipotalâmico-pituitário-adrenal em indivíduos com esquizofrenia

Os efeitos do estresse na função do eixo hipotalâmico-pituitário-adrenal em indivíduos com esquizofrenia

Predicting Risk and the Emergence of Schizophrenia

Attention-deficit/hyperactivity disorder in the offspring following prenatal maternal bereavement: a nationwide follow-up study in Denmark

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