Prenatal lipopolysaccharide disrupts maternal behavior, reduces nest odor preference in pups, and induces anxiety: Studies of F1 and F2 generations

Penteado, Sandra H.W.N.; Teodorov, Elizabeth; Kirsten, Thiago Berti; Eluf, Bianca P.; Reis-Silva, Thiago Marinho; Acenjo, Michelli; Melo, Rafael César de; Suffredini, Ivana Barbosa; Bernardi, Maria Martha

doi:10.1016/j.ejphar.2014.05.058

Cited by 22 publications

(21 citation statements)

References 63 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…However, we were surprised that there was not a maternal preference for male vs. female pups, as reported previously (Moore, 1985). Despite evidence that MIA disrupts maternal care (Meyer et al, 2006b;Penteado et al, 2014), in line with other observations Fig. 4.…”

Section: Considerations Of Environmentsupporting

confidence: 91%

Tracing the trajectory of behavioral impairments and oxidative stress in an animal model of neonatal inflammation

et al. 2015

View full text Add to dashboard Cite

Section: Considerations Of Environmentsupporting

confidence: 91%

Tracing the trajectory of behavioral impairments and oxidative stress in an animal model of neonatal inflammation

et al. 2015

View full text Add to dashboard Cite

“…Strong evidence indicates that LPS exposure during late embryogenesis could also result in noncognitive behavioral abnormalities in pre‐ or adult, such as altered anxiety‐like and depressive‐like behaviors and locomotor activity, prepulse inhibition deficits, and impaired species‐typical behaviors (hoarding and nesting; Asiaei, Solati, & Salari, ; Enayati et al, ; Fortier et al, ; Glass et al, ; Golan, Stilman, Lev, & Huleihel, ; Hsueh et al, ; Penteado et al, ; Wischhof et al, ). But it is noteworthy that these studies varied with respect to different methodology used, making it difficult to compare across studies.…”

Section: Discussionmentioning

confidence: 99%

“…Bacterial infections have a high prevalence in women of reproductive age. Increasing evidence indicates that modifications of the “in utero” environment due to maternal bacterial infection can result in cognitive and behavioral disorders in pre‐ or adult offspring, such as impairments in spatial learning and memory (Batinic et al, ; Chlodzinska, Gajerska, Bartkowska, Turlejski, & Djavadian, ; Glass, Norton, Fox, & Kusnecov, ; Simões et al, ) and object recognition (Glass et al, ; Wischhof, Irrsack, Osorio, & Koch, ), increased locomotor activity (Batinic et al, ; Glass et al, ) and anxiety (Enayati et al, ; Glass et al, ; Hsueh et al, ; Penteado et al, ) and decreased prepulse inhibition of acoustic startle (Fortier, Luheshi, & Boksa, ; Glass et al, ; Wischhof et al, ) and social behaviors (Glass et al, ; Hsueh et al, ). Lipopolysaccharide (LPS) injection in the pregnancy is a widely accepted mouse model of maternal bacterial infection.…”

Section: Introductionmentioning

confidence: 99%

Lipopolysaccharide exposure during late embryogenesis triggers and drives Alzheimer‐like behavioral and neuropathological changes in CD‐1 mice

et al. 2020

View full text Add to dashboard Cite

Introduction Infections could contribute to Alzheimer's disease (AD) neuropathology in human. However, experimental evidence for a causal relationship between infections during the prenatal phase and the onset of AD is lacking. Methods CD‐1 mothers were intraperitoneally received lipopolysaccharide (LPS) with two doses (25 and 50 μg/kg) or normal saline every day during gestational days 15–17. A battery of behavioral tasks was used to assess the species‐typical behavior, sensorimotor capacity, anxiety, locomotor activity, recognition memory, and spatial learning and memory in 1‐, 6‐, 12‐, 18‐, and 22‐month‐old offspring mice. An immunohistochemical technology was performed to detect neuropathological indicators consisting of amyloid‐β (Aβ), phosphorylated tau (p‐tau), and glial fibrillary acidic protein (GFAP) in the hippocampus. Results Compared to the same‐aged controls, LPS‐treated offspring had similar behavioral abilities and the levels of Aβ42, p‐tau, and GFAP at 1 and 6 months old. From 12 months onward, LPS‐treated offspring gradually showed decreased species‐typical behavior, sensorimotor ability, locomotor activity, recognition memory, and spatial learning and memory, and increased anxieties and the levels of Aβ42, p‐tau, and GFAP relative to the same‐aged controls. Moreover, this damage effect (especially cognitive decline) persistently progressed onwards. The changes in these neuropathological indicators significantly correlated with impaired spatial learning and memory. Conclusions Prenatal exposure to low doses of LPS caused AD‐related features including behavioral and neuropathological changes from midlife to senectitude.

show abstract

“…Environmental information that is received by a mother can induce phenotypic changes in her offspring, commonly known as maternal or intergenerational effects (CURNO et al, 2009;WALKER et al, 2011;PENTEADO et al, 2014).…”

Section: Introductionmentioning

confidence: 99%

“…Certain cues in the maternal environment (e.g., the prevalence of predators) or maternal infection can lead to behavioral, morphological, and immunological changes in the subsequent generation (WALKER et al, 2011;PENTEADO et al, 2014). To our knowledge, no transgenerational studies have evaluated the effects of maternal periodontal disease on reproductive performance in subsequent generations.…”

Section: Introductionmentioning

confidence: 99%

Maternal periodontitis induces intergenerational injuries on reproductive performance of adult female rat offspring

Pimentel

Casati

Cirano

et al. 2017

Braz. J. Vet. Res. Anim. Sci.

View full text Add to dashboard Cite

Substantial evidence suggests a direct link between periodontitis in pregnant women and subsequent adverse pregnancy outcomes. However, no studies have evaluated the transgenerational effects of periodontitis on the reproductive performance of subsequent generations. The present study investigated whether maternal periodontal disease exerts deleterious transgenerational effects on reproductive performance in F1 female rats. Rat female offspring from mothers that were subjected to experimentally induced periodontitis or sham operation were mated with sexually experienced male rats. The weight and reproductive performance of these F1 offspring were evaluated on gestation day 21, including maternal weight, litter weight, individual pup weight, number of pups, and number of resorptions. The percentage of dams with resorptions and the litter weight/number of pups were also calculated. Compared with the control group, an increase was observed in the percentage and number of resorptions and litter weight/number of pups, and a decrease was observed in the number of pups born in the experimental group. Maternal weight, litter weight, and individual pup weight were not different between the control and experimental groups. Maternal periodontitis impaired reproductive performance in the F1 generation. We showed that periodontitis may induce reproductive injury in adult offspring even if the offspring do not undergo any inflammatory/infectious process during their postnatal life or during gestation. These findings reinforce the importance of oral care during pregnancy. Keywords: Maternal immune activation. Reproduction. Intergenerational effect. Periodontitis. Rat. ResumoExistem evidências substanciais de uma relação direta entre periodontite em mulheres grávidas com efeitos adversos reprodutivos. No entanto, nenhum estudo avaliou os efeitos intergeracionais da periodontite sobre o desempenho reprodutivo das gerações subsequentes. O presente estudo investigou se a doença periodontal materna exerce efeitos intergeracionais deletérios sobre o desempenho reprodutivo em ratos fêmeas da geração F1. Assim, filhas de ratas cujas mães foram submetidas a periodontite experimental ou falsamente operadas foram acasaladas com ratos machos sexualmente experientes. O peso corporal e desempenho reprodutivo da geração F1 foram avaliados no dia 21 de gestação, incluindo o peso materno, peso da ninhada, peso da individual dos filhotes, número de filhotes e de reabsorções. A percentagem de fêmeas com reabsorção e o peso da ninhada/número de filhotes também foram calculados. Comparados com o grupo controle, observou-se aumento na porcentagem e número de reabsorções e no peso da ninhada/ número de filhotes, e decréscimo no número de filhotes nascidos no grupo experimental. O peso materno, peso da ninhada e individual dos filhotes não foi diferente entre o controle e experimental. Estes resultados mostram que a periodontite experimental materna prejudica o desempenho reprodutivo da geração F1, mesmo que estes animais não tenham sido expo...

show abstract

Prenatal lipopolysaccharide disrupts maternal behavior, reduces nest odor preference in pups, and induces anxiety: Studies of F1 and F2 generations

Cited by 22 publications

References 63 publications

Tracing the trajectory of behavioral impairments and oxidative stress in an animal model of neonatal inflammation

Tracing the trajectory of behavioral impairments and oxidative stress in an animal model of neonatal inflammation

Lipopolysaccharide exposure during late embryogenesis triggers and drives Alzheimer‐like behavioral and neuropathological changes in CD‐1 mice

Maternal periodontitis induces intergenerational injuries on reproductive performance of adult female rat offspring

Contact Info

Product

Resources

About