Prenatal ketamine exposure impairs prepulse inhibition via arginine vasopressin receptor 1A-mediated GABAergic neuronal dysfunction in the striatum

Kim, Aeseul; Gu, Sun Mi; Lee, Haemiru; Kim, Dong-Eun; Hong, Jin Tae; Yun, Jaesuk; Jin, Hongzhe

doi:10.1016/j.biopha.2023.114318

Cited by 3 publications

(1 citation statement)

References 54 publications

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“…Repeated opioid (such as papaverine, morphine, heroin, ketamine, et al) exposure strengthens synaptic NMDAR activities in the NAc [73]. Then, opioids elicit robust dopamine transients in the NAc through the derepression of dopamine neurons via the NMDAR antagonism (Figure 1) [74][75][76]. On the other hand, the long-range GABAergic projection from the VTA to the ventral NAc shell, but not to the NAc core or dorsal NAc shell, is also engaged in rewarding and reinforcement behaviors [77].…”

Section: Drugs For Gabaergic Neuronsmentioning

confidence: 99%

Substance Addiction Rehabilitation Drugs

Yuan,

Jiang,

Zhang

et al. 2024

Pharmaceuticals

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The relapse rate of substance abusers is high, and addiction rehabilitation adjunct drugs need to be developed urgently. There have been numerous reports on blocking the formation of substance addiction, but studies on drugs that can alleviate withdrawal symptoms are very limited. Both the dopamine transporter (DAT) hypothesis and D3 dopamine receptor (D3R) hypothesis are proposed. DAT activators reduce the extracellular dopamine level, and D3R antagonists reduce the neuron’s sensitivity to dopamine, both of which may exacerbate the withdrawal symptoms subsequently. The D3R partial agonist SK608 has biased signaling properties via the G-protein-dependent pathway but did not induce D3R desensitization and, thus, may be a promising drug for the withdrawal symptoms. Drugs for serotoninergic neurons or GABAergic neurons and anti-inflammatory drugs may have auxiliary effects to addiction treatments. Drugs that promote structural synaptic plasticity are also discussed.

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Section: Drugs For Gabaergic Neuronsmentioning

confidence: 99%

Substance Addiction Rehabilitation Drugs

Yuan,

Jiang,

Zhang

et al. 2024

Pharmaceuticals

View full text Add to dashboard Cite

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Is the antidepressant effect of ketamine separate from its psychotomimetic effect? A review of rodent models

Acero-Castillo,

Correia,

Caixeta

et al. 2024

Neuropharmacology

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Vasotocin receptor gene genotypes moderate the relationship between cortical thickness and sensory processing

Lee,

Cheong,

Ryu

et al. 2023

Transl Psychiatry

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Sensory processing is the process by which the central nervous system gathers, interprets, and regulates sensory stimuli in response to environmental cues. However, our understanding of the genetic factors and neuroanatomical correlations that influence sensory processing is limited. The vasotocin system modulates sensory input responsiveness, making it a potential candidate for further investigation. Additionally, human neuroimaging studies have demonstrated that the ability to modulate sensory stimuli is related to neuroanatomical features such as cortical thickness. Therefore, this study aimed to examine the relationship between functional polymorphisms in vasotocin receptor (VTR) genes, sensory profiles, and neuroanatomical correlations. We used structural magnetic resonance imaging (MRI) and the Adolescent/Adult Sensory Profile (AASP) questionnaire in 98 healthy adult participants to assess sensory processing and identified seven single nucleotide polymorphisms. We found that A-allele carriers of rs1042615 in VTR had higher scores for “sensory sensitivity” and “sensation avoiding”. Moreover, higher scores for three AASP subscales were associated with decreased cortical thickness in various regions, including the right precentral, paracentral, and fusiform gyri, as well as bilateral inferior temporal gyri. This study sheds light on the potential role of genetic variations in the VTR in modulating sensory processing and correlation with cortical thickness which has future implications for better understanding sensory abnormalities in neurodevelopmental disorders.

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Prenatal ketamine exposure impairs prepulse inhibition via arginine vasopressin receptor 1A-mediated GABAergic neuronal dysfunction in the striatum

Cited by 3 publications

References 54 publications

Substance Addiction Rehabilitation Drugs

Substance Addiction Rehabilitation Drugs

Is the antidepressant effect of ketamine separate from its psychotomimetic effect? A review of rodent models

Vasotocin receptor gene genotypes moderate the relationship between cortical thickness and sensory processing

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