Prenatal hyperhomocysteinemia as a model of oxidative stress of the brain

Makhro, Asya; Mashkina, Anna P.; Solenaya, O. A.; Трунова, О. А.; Kozina, L S; Arutyunian, A. V.; Bulygina, E. R.

doi:10.1007/s10517-008-0233-0

Cited by 32 publications

(23 citation statements)

References 8 publications

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“…Some reports suggested that hyperhomocysteinaemia causes oxidative stress in different tissues in adult mammals (Mujumdar et al 2001;Wang et al 2004;Makhro et al 2008;Sema et al 2010). It was hypothesised that increased lipid peroxidation levels might be an important risk factor for this (Sema et al 2010).…”

Section: Discussionmentioning

confidence: 99%

Effect of short-term administration of methionine on the ovary and uterus in a rat

et al. 2017

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Methionine is necessary for development but overuse of it can not only cause growth retardation but also damage organs such as the liver and cardiovascular system. The purpose of this research was to determine the effect of shortterm administration of methionine on the ovaries and uterus in a rat. Forty adult female rats were randomly allocated into four equal groups: each received 50, 100 or 200 mg/kg BW Lmethionine in 0.5 mL normal saline or just 0.5 mL normal saline (control) intraperitoneally for 20 days. On day 21, all rats were euthanized and tissues were taken for histological evaluation. Also, plasma homocysteine (Hcy) level was assessed in all groups. No difference was observed between the ovaries in all treatment and control groups; however, in methionine-injected groups, some histopathological changes were observed in the uterus such as atrophy in endometrial glands and the presence of inflammatory cells in the endo-and myometrium. Histopathological findings showed uterine infiltration of inflammatory cells in the methionine-injected groups which increased with increasing injected methionine levels. Also, all treatment groups showed increasing homocysteine levels compared to controls. These results show short-term administration of methionine and its associated homocysteinaemia has no effect on the ovary and its follicular structure.

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Section: Discussionmentioning

confidence: 99%

Effect of short-term administration of methionine on the ovary and uterus in a rat

et al. 2017

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“…Homocysteinuria is a metabolic disorder characterized by deficiency of the enzyme cystathione bsynthase activity leading to accumulation of homocysteine. Homocysteine causes free radical formation and severe neurological dysfunction, which is thought to be due to the increased oxidative stress (263). Administration of homocysteine to adult rats caused severe memory impairments in the stepdown inhibitory avoidance test that was prevented by pretreatment with vitamins C and E, suggesting that ROS play a critical role in the onset of memory dysfunction during homocysteinuria (358).…”

Section: Ros In Multiple Disease Statesmentioning

confidence: 99%

Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory

Massaad

Klann

2011

Antioxidants & Redox Signaling

471

350

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The brain is a metabolically active organ exhibiting high oxygen consumption and robust production of reactive oxygen species (ROS). The large amounts of ROS are kept in check by an elaborate network of antioxidants, which sometimes fail and lead to neuronal oxidative stress. Thus, ROS are typically categorized as neurotoxic molecules and typically exert their detrimental effects via oxidation of essential macromolecules such as enzymes and cytoskeletal proteins. Most importantly, excessive ROS are associated with decreased performance in cognitive function. However, at physiological concentrations, ROS are involved in functional changes necessary for synaptic plasticity and hence, for normal cognitive function. The fine line of role reversal of ROS from good molecules to bad molecules is far from being fully understood. This review focuses on identifying the multiple sources of ROS in the mammalian nervous system and on presenting evidence for the critical and essential role of ROS in synaptic plasticity and memory. The review also shows that the inability to restrain either age-or pathology-related increases in ROS levels leads to opposite, detrimental effects that are involved in impairments in synaptic plasticity and memory function.

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“…Moreover, other factors may also exert important effects, such as oxidative stress [14], [15], exercise [16] and epigenetic modifications [5].…”

Section: Introductionmentioning

confidence: 99%

Central and Systemic Responses to Methionine-Induced Hyperhomocysteinemia in Mice

Rezende

D’Almeida

2014

PLoS ONE

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Hyperhomocysteinemia has been considered a risk factor for neuropsychiatric disorders, but the mechanisms involved in this process have not been completely elucidated. The aim of this study was to analyze the influence of hyperhomocysteinemia induction by methionine supplementation considering different levels and periods of exposure in mice. For this purpose, methionine supplementation at concentrations of 0.5 and 1% were administered in water to increase homocysteinemia in male C57BL/6 mice, and was maintained for 3 time periods (2, 4 and 6 months of treatment). The results from one-carbon metabolism parameters, brain-derived neurotrophic factor (BDNF) concentrations and behavioral evaluation were compared. The 0.5% supplementation was efficient in increasing plasma homocysteine levels after 2 and 6 months. The 1% supplementation, increased plasma homocysteine after 2, 4 and 6 months. Little influence was observed in cysteine and glutathione concentrations. Frontal cortex BDNF levels showed a lack of treatment influence in all periods; only the expected decrease due to increasing age was observed. Moreover, the only behavioral alteration observed using a novel object recognition task was that which was expected with increasing age. We found that responses to hyperhomocysteinemia varied based on how it was reached, and the length of toxicity. Moreover, hyperhomocysteinemia can affect the normal pattern of one carbon metabolism during age increase in mice. These findings allow the establishment of a reliable animal model for studies in this field.

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Prenatal hyperhomocysteinemia as a model of oxidative stress of the brain

Cited by 32 publications

References 8 publications

Effect of short-term administration of methionine on the ovary and uterus in a rat

Effect of short-term administration of methionine on the ovary and uterus in a rat

Reactive Oxygen Species in the Regulation of Synaptic Plasticity and Memory

Central and Systemic Responses to Methionine-Induced Hyperhomocysteinemia in Mice

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