Prenatal heroin exposure

Zhu, Jinyong; Stadlin, Alfreda

doi:10.1016/s0892-0362(99)00076-8

Cited by 21 publications

(2 citation statements)

References 83 publications

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“…The results have varied depending on the outcome being investigated. Regarding learning and memory, prenatal morphine or heroin exposure appeared to exert a more negative effect on female than male rats (Šlamberová et al, 2001;Zhu & Stadlin, 2000), whereas studies examining analgesia, anxiety, and depression have reported varying results for different drugs between the sexes (e.g., Gholami et al, 2020).…”

Section: Sex Differencesmentioning

confidence: 95%

Prenatal exposure to opioids.

Nygaard¹,

Andersen²

2023

APA Handbook of Neuropsychology, Volume 1: Neurobehavioral Disorders and Conditions: Accepted Science and Open Questions (Vol.

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Section: Sex Differencesmentioning

confidence: 95%

Prenatal exposure to opioids.

Nygaard¹,

Andersen²

2023

APA Handbook of Neuropsychology, Volume 1: Neurobehavioral Disorders and Conditions: Accepted Science and Open Questions (Vol.

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“…While paternal heroin exposure has only recently been explored, several studies of prenatal heroin exposure have been done in mice models. For example, Zhu et al found that heroin-exposed pups had a marked reduction in birth weight, and the postnatal weight gain in these pups was significantly lower than that of controls, particularly in female pups [78]. These female pups also showed a significant increase in ambulation and rearing, suggesting that prenatal heroin exposure could result in a sex-specific delay of postnatal development and learning [78].…”

Section: Heroinmentioning

confidence: 99%

Generational Effects of Opioid Exposure

2021

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The inheritance of substance abuse, including opioid abuse, may be influenced by genetic and non-genetic factors related to the environment, such as stress and socioeconomic status. These non-genetic influences on the heritability of a trait can be attributed to epigenetics. Epigenetic inheritance can result from modifications passed down from the mother, father, or both, resulting in either maternal, paternal, or parental epigenetic inheritance, respectively. These epigenetic modifications can be passed to the offspring to result in multigenerational, intergenerational, or transgenerational inheritance. Human and animal models of opioid exposure have shown generational effects that result in molecular, developmental, and behavioral alterations in future generations.

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Survival, differentiation, and reversal of heroin neurobehavioral teratogenicity in mice by transplanted neural stem cells derived from embryonic stem cells

Kazma¹,

Izrael

Revel

et al. 2009

J of Neuroscience Research

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Cell therapies in animal models of neurobehavioral defects are normally derived from neural stem cells (NSC) of the developing cortex. However, the clinical feasibility of NSC therapies would be greatly improved by deriving transplanted cells and from a tissue culture source that is self-renewing, containing cells that potentially differentiate into the desired neuronal phenotypes. These cultures can be engineered to contain the appropriate factors to support their therapeutic action and likely evoke lesser immune reactions. In the current study, we employed our model of mice neurobehaviorally impaired via prenatal exposure to heroin, to test the therapeutic efficacy of NSC derived from murine embryonic stem cells culture (ESC). The culture contained elongated bipolar cells, 90% of which are positive for nestin, the intermediate filament protein found in neural precursors. After removal of growth factors, the NSC differentiated into neurons (34.0% +/- 3.8% NF-160 positive), including cholinergic cells (ChAT positive), oligodendrocytes (29.9% +/- 4.2% O(4)), and astrocytes (36.1% +/- 4.7% GFAP positive). Reverse transcriptase polymerase chain reaction (RT-PCR) analysis confirmed the immunocytochemical findings. Mice made deficient in Morris maze behavior by prenatal heroin exposure (10 mg/kg heroin s.c. on gestational days 9-18) were transplanted into the hippocampus region on postnatal day 35 with the ES culture-derived NSC (ES-NSC) labeled with dialkylcarbocyanine (Dil) cell tracker. Dil+ and NF160+ cells were detected in the hippocampal region (50% +/- 8% survival). The transplantation completely restored maze performance to normal; e.g., on day 3, transplantation improved the behavior from the deficient level of 11.9-sec latency to the control of 5.6-sec latency (44.5% improvement).

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Prenatal heroin exposure

Cited by 21 publications

References 83 publications

Prenatal exposure to opioids.

Prenatal exposure to opioids.

Generational Effects of Opioid Exposure

Survival, differentiation, and reversal of heroin neurobehavioral teratogenicity in mice by transplanted neural stem cells derived from embryonic stem cells

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