Prenatal Growth Pattern of the Human Maxilla

Lee, S.K.; Kim, So Hyun; Lim, Chae Young; Chi, Je-Geun

doi:10.1159/000147334

Cited by 18 publications

(11 citation statements)

References 4 publications

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“…A number of investigators showed, that biomathematical methods are useful to show the fetal growth relations of different facial skeleton structures (Houpt, 1970;Kvinnsland, 1970;Lavelle and Moore, 1970;Diewert, 1985;Siegel et al , 1987;Burdi et al , 1988;Kimes et al, 1988;Lee et al, 1992; Mandarim-deLacerda and Urania-Alves, 1992). However, no report is available about the biomathematical analysis of the fetal maxillary sinus.…”

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confidence: 99%

Investigations on the Growth Pattern of the Maxillary Sinus in Japanese Human Fetuses

Koppe

Yamamoto

Tanaka

et al. 1994

Okajimas Folia Anatomica Japonica

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Summary: The growth pattern of the maxillary sinus was analyzed using 18 human fetuses of both sexes between 9 and 21 weeks of age postconception. The paraffin embedded specimens were cut in series in the frontal and the transversal plane, respectively. The inner surface of the maxillary sinuses was redrawn and surrounded with a digitizer and then the volumes were calculated. A correlation analysis as well as a simple linear regression analysis between the values of the maxillary sinus, different linear values of the nasal cavity and the crown-rump length (CRL) served to prove possible growth relations. The maxillary sinus' Anlage was already identifiable in the 29.8 mm (CRL) fetus. From this first appearance, the maxillary sinus expands not only in posterior direction but also in anterior direction from 11 weeks onwards. The maxillary sinus volume increased from 0.0008 mm3 at the age of 9 weeks to more than 9 mm3 at the age of 21 weeks. The results of the statistical analysis indicated, that the relationship between the maxillary sinus' Anlage and the nasal cavity were strongly influenced by the body size (CRL). This study suggests, that the growth of the maxillary sinus follows special regularities in the early fetal development.

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confidence: 99%

Investigations on the Growth Pattern of the Maxillary Sinus in Japanese Human Fetuses

Koppe

Yamamoto

Tanaka

et al. 1994

Okajimas Folia Anatomica Japonica

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“…Although the ossification is affected by complicated factors of endogeneous and exogeneous origins (Morimoto et al, 1987;Merida-Velasco et al, 1993Orliaguet et al, 1993aOrliaguet et al, , 1993bOrliaguet et al, , 1994Bach-Petersen et al, 1994;Ishizeki et al, 1999), the embryonal bones are primarily deposited by intramembranous ossification initiated from the primary growth center (Pritchett, 1991;Rosati et al, 1994;Nyska et al, 1995). In the previous studies about prenatal maxillary and mandibular growth patterns, we observed the anterior and posterior maxillary primary growth centers (MxPGCs) and MdPGCs, which have characteristic radiating trabecular patterns both in the histological and radiological observations (Lee et al, 1992(Lee et al, , 2001). We also mentioned that the MxPGC and MdPGC were embryonal initial ossifying sites of jaws, but they are neither continuously proliferative nor renewed during the late fetal and postnatal period.…”

Section: Discussionmentioning

confidence: 95%

Radiological trace of mandibular primary growth center in postnatal human mandibles

Lee

Park

et al. 2006

Anat. Rec.

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The mandibular primary growth center (MdPGC) of human fetus was conspicuously defined in the soft X-ray view of fetal mandibles. As the peripheral adaptive growth of mandible advances during the postnatal period, the MdPGC image became overshadowed by condensed cortical bones in soft X-ray view. In this study, we traced a sclerotic sequela of MdPGC during the postnatal period. Panoramic radiograms of 200 adults and soft X-ray views of 30 dried adult mandibles were analyzed by statistical methods. The former clearly showed an MdPGC below the middle portion of apices of canine and first premolar, which was distinguishable from mental foramen, and the latter also showed the MdPGC at the same area as a radiating and condensed radiopaque image, measuring 0.5-1.0 cm in diameter. This MdPGC position was seldom changed in the elderly people, even in the edentulous mandibles. Additionally, in the radiological examination, the benign tumors including odontogenic cysts hardly involved the MdPGC, while the malignant tumors of both primary and metastatic cancer frequently destroyed the MdPGC.

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“…Despite the absence of the vomer the palatal processes 'met in the midline of maxilla and grew downward erroneously. Although the anterior and posterior primary growth centers could be traced in the maxilla, the maxillary trapezoid structure, composed of pairs of anterior and posterior primary growth centers (Lee et al, 1992), was abnormally narrowed due to marked reduction of anterior and posterior maxillary widths (Fig. Ic).…”

Section: Resultsmentioning

confidence: 99%

Craniofacial Dysmorphia of Frontal Proboscis in Holoprosencephaly

Lee

Suh

1993

Congenital Anomalies

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We have examined eleven cases of holoprosencephaly with special emphasis on the frontal proboscis. Although the nostril appears blind ended grossly, the proboscis has a single slender midline nostril lined with squamous mucosa containing numerous sebaceous glands. It is actually connected to a poorly formed but definite nasal cavity microscopically. The inner portion of the nostril tunnel is lined by olfactory mucosa containing numerous subjacent secretary glands. Despite the absence of olfactory bulbs and tracts the cartilaginous nasal capsule is identified along with abnormal nasal cavity. However, the nasal capsule is hypoplastic, and has an aberrant nasal septum and no concha. In severe form of holoprosencephaly, i.e., cyclopia, the nasal capsule is noted above the level of the ethmoid plate, in which case the nasal cavity dose not communicate with nasopharynx because it is too distant from the hypoplastic maxilla. Therefore, choanal atresia is resulted. Although unique maxillary bone comprises the whole upper jaw, the failure of fusion between vomeronasal septum and palatal processes in holoprosencephaly results in abnormal maxillary bone which is characterized by a narrow palate without palatal arch form. Nevertheless, through serial microscopic sections we could find a space between the posterior maxilla and the sphenoid bone, which is composed of adipose tissue and is similar in shape to the nasal capsule. This space is thought to be made for the nasal capsule during early developmental period. The present study suggests that the frontal proboscis in holoprosencephaly is an undescended nose. In most cases it is connected to the aberrant nasal cavity which is located beneath the proboscis. The level of proboscis descends gradually toward normal nose position as the severity of holoprosencephaly decreased from cyclopia, ethmocephaly, cebocephaly, to premaxillary agenesis. Key words: frontal proboscis, holoprosencephaly, craniofacial dysmorphia

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Prenatal Growth Pattern of the Human Maxilla

Cited by 18 publications

References 4 publications

Investigations on the Growth Pattern of the Maxillary Sinus in Japanese Human Fetuses

Investigations on the Growth Pattern of the Maxillary Sinus in Japanese Human Fetuses

Radiological trace of mandibular primary growth center in postnatal human mandibles

Craniofacial Dysmorphia of Frontal Proboscis in Holoprosencephaly

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