Prenatal Genetic Services: Toward a National Data Base

Fj, Meaney; Sm, Riggle; Gc, Cunningham; Ks, Stern; Jg, Davis

doi:10.1097/00003081-199309000-00009

Cited by 12 publications

(12 citation statements)

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“…Prior studies have observed geographic differences in access to genetic services (Tordo et al, 1989) as well as other types of related services, including referral to specialist care for children with special health care needs (Young et al, 2005), prenatal genetic services (Meaney et al, 1993), and pediatric speech pathology (O'Callaghan et al, 2005). In fact, one study noted distance from a genetics center as a factor in physicians' willingness to refer children with developmental delays to these services (Chen et al, 2008).…”

Section: Discussionmentioning

confidence: 99%

Proximity of pediatric genetic services to children with birth defects in Texas

Case

Canfield

Barnett

et al. 2008

Birth Defects Research

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Section: Discussionmentioning

confidence: 99%

Proximity of pediatric genetic services to children with birth defects in Texas

Case

Canfield

Barnett

et al. 2008

Birth Defects Research

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“…The differences in prenatal diagnosis rates may reflect differences in access to or utilization of prenatal care. Several studies have reported differences in access to prenatal diagnostic screens and tests by race/ethnicity [12][13][14][15][16][17]. And a recent investigation found that prenatal care utilization differed among racial/ ethnic groups in Hawaii, although the differences appeared related to differences in socioeconomic factors between the groups [18].…”

Section: Discussionmentioning

confidence: 99%

Prenatal Diagnosis and Elective Termination of Neural Tube Defects in Hawaii, 1986–1997

Forrester¹,

Merz²

2000

Fetal Diagn Ther

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Objective: To determine the influence of various factors on the prenatal diagnosis and elective termination of neural tube defects (NTDs) in Hawaii in 1986–1997. Methods: Data from a birth defects registry were analyzed and included 245 cases. Results: 74% of the cases were prenatally diagnosed and 48% were terminated. Anencephaly was more likely to be prenatally diagnosed and electively terminated than spina bifida or encephalocele. Other factors such as maternal age, race/ethnicity, place of residence, and elevated maternal serum α-fetoprotein influenced the prenatal diagnosis and/or elective termination of NTD-affected pregnancies. However, a given factor may influence prenatal diagnosis and elective termination in different ways. Conclusions: Various diagnostic and demographic factors can influence the prenatal diagnosis and the subsequent termination of NTD-affected pregnancies.

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“…The subsequent elective termination of prenatally diagnosed cases has been found to affect the prevalence of Down syndrome among live births, an effect influenced by such demographic factors as state of residence (Bishop et al, 1997;Krivchenia et al, 1993), maternal age (Caruso and Holmes, 1994;Bishop et al, 1997), and maternal race/ethnicity (Bishop et al, 1997). Some of these differences may result from variations in access to prenatal screening from state to state and between counties and rural and urban regions within a single state (Adams et al, 1981b;Naber et al, 1987;Meaney et al, 1993) and with maternal race/ethnicity (Krivchenia et al, 1993;Adams et al, 1981b;Meaney et al, 1993;Sokal et al, 1980;Wilson et al, 1992;Kuppermann et al, 1996). This study examined whether certain maternal demographic factors affected the prenatal diagnosis and elective termination of fetuses with Down syndrome in Hawaii.…”

Section: Introductionmentioning

confidence: 99%

Prenatal diagnosis and elective termination of Down syndrome in a racially mixed population in Hawaii, 1987–1996

Forrester¹,

Merz²

1999

Prenat. Diagn.

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The impact of demographic factors on the prenatal diagnosis and elective termination of Down syndrome in Hawaii between 1987 and 1996 were examined. Data were obtained from a population-based birth defects registry and included 306 Down syndrome cases. 131 (43 per cent) of the cases were prenatally diagnosed. Of the prenatally diagnosed cases, 110 (84 per cent) were electively terminated. Advanced maternal age or having a maternal serum alpha-fetoprotein screen performed increased the probability of having an affected pregnancy prenatally diagnosed and electively terminated. Far East Asians were substantially more likely to have an affected pregnancy prenatally diagnosed and electively terminated. Pacific Islanders and Filipinos were less likely to have cases prenatally diagnosed and electively terminated. Prenatally diagnosed and electively terminated Down syndrome cases had disproportionately fewer additional birth defects than live births or fetal demises, suggesting that for many of the electively terminated cases additional birth defects may not have been identified. This implies that the elective termination of Down syndrome-affected pregnancies may influence not only the Down syndrome prevalence but also that of other birth defects.

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Prenatal Genetic Services: Toward a National Data Base

Cited by 12 publications

References 0 publications

Proximity of pediatric genetic services to children with birth defects in Texas

Proximity of pediatric genetic services to children with birth defects in Texas

Prenatal Diagnosis and Elective Termination of Neural Tube Defects in Hawaii, 1986–1997

Prenatal diagnosis and elective termination of Down syndrome in a racially mixed population in Hawaii, 1987–1996

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