Prenatal exposure to traffic-related air pollution and risk of congenital diseases in South Korea

Lee, Kyung-Shin; Lim, Youn Hee; Kim, Soontae; Bae, Hyun Cheol; Han, Changwoo; Lee, Young Ah; Hong, Yun Chul

doi:10.1016/j.envres.2020.110060

Cited by 14 publications

(6 citation statements)

References 49 publications

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“…Subsequently, more and more scholars have noticed that the susceptibility window of air pollution may not be completely consistent with the life cycle of heart development. They are no longer limited to measuring the exposure within 3–8 weeks of gestation, and divide pregnancy into longer exposure periods, such as early, middle, late trimester or gestational month ( 12 , 21 – 23 ). A population-based longitudinal case-control study in China found that exposure to higher levels of air pollutants during the first trimester was associated with an increased risk of coronary heart disease in offspring ( 24 ).…”

Section: Discussionmentioning

confidence: 99%

Maternal exposure to ambient air pollution and risk of congenital heart defects in Suzhou, China

Sun

Wang

et al. 2023

Front. Public Health

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BackgroundMore and more studies have investigated the association between maternal exposure to ambient air pollution during pregnancy and incidence of congenital heart defects (CHDs), but results are controversial. The aim of this study was to investigate whether maternal exposure to air pollutants (PM10, PM2.5, NO2, CO, SO2) are associated with an increased risk of congenital heart defects in Suzhou city, China.MethodsBased on the birth defect monitoring system of Suzhou city and the Environmental Health Department of Suzhou CDC, the birth defect monitoring data and concentrations of five air pollutants (PM10, PM2.5, NO2, CO, SO2) in Suzhou city from 2015 to 2019 were obtained. The distribution of demographic characteristics of children with birth defects and exposure to air pollutant concentrations during different pregnancy periods were analyzed, Chi-square test was used to analyze whether there were statistical differences in the distribution of parturient woman age, pregnant weeks, times of pregnancy, as well as fetal sex and birth weight among children with congenital heart defects and other defects. Logistic regression model was further established to calculate the adjusted odds ratios (aORs) and 95% confidence intervals (CI) for the association between exposure to these ambient air pollutants during pregnancy and CHDs.ResultsA total of 5,213 infants with birth defects were recruited in this study from 2015 to 2019, the top five birth defects in Suzhou were syndactyly, congenital heart disease, ear malformation, cleft lip and palate, and hypospadias, and the proportion of congenital heart disease increased. The level of maternal exposures (mean ± sd) was highest in first trimester amongst pregnant women in Suzhou city. Compared to other birth defects, we observed significant increasing associations between PM2.5 exposure during second and third trimester with risk of CHDs, aORs were 1.228 and 1.236 (95% CI: 1.141–1.322, 1.154–1.324 separately) per a 10 μg/m3 change in PM2.5 concentration. Maternal NO2 exposure was significantly associated with CHDs in first trimester (aOR = 1.318; 95% CI: 1.210–1.435).ConclusionsOur study contributes to explore the current state of Suzhou air quality and the association between maternal air pollution exposure and congenital heart defects. Exposure to PM2.5 and NO2 is thought to increase the risk of CHDs, but comprehensive description of these associations will be needed in future studies.

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Section: Discussionmentioning

confidence: 99%

Maternal exposure to ambient air pollution and risk of congenital heart defects in Suzhou, China

Sun

Wang

et al. 2023

Front. Public Health

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“…A recent Korean study reported that PM 2.5 exposure in the second trimester, in addition to the first trimester, also contributes to the development of cardiovascular, musculoskeletal, and urogenital anomalies. 15 …”

Section: Discussionmentioning

confidence: 99%

“…Moreover, there is a complete lack of studies studying the relationship between PM exposure and congenital anomalies in the field of pediatric surgery. 14 15 South Korea began measuring PM 2.5 concentrations in five metropolitan areas in 2013, with nationwide measurement and reporting of PM 2.5 concentration forecasts beginning in 2015. 1 As of October 2020, PM 2.5 was being measured at 558 monitoring stations nationwide, with a growing number of stations.…”

Section: Introductionmentioning

confidence: 99%

Correlation between Exposure to Fine Particulate Matter (PM_2.5) during Pregnancy and Congenital Anomalies: Its Surgical Perspectives

et al. 2021

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Background Fine particulate matter (PM 2.5 ) can easily penetrate blood vessels and tissues through the human respiratory tract and cause various health problems. Some studies reported that particular matter (PM) exposure during pregnancy is associated with low birth weight or congenital cardiovascular anomalies. This study aimed to investigate the correlation between the degree of exposure to PM ≤ 2.5 μm (PM 2.5 ) during pregnancy and congenital anomalies relevant to the field of pediatric surgery. Methods Mother-infant dyads with registered addresses in the Metropolitan City were selected during 3 years. The electronic medical records of mothers and neonates were retrospectively analyzed, with a focus on maternal age at delivery, date of delivery, gestation week, presence of diabetes mellitus (DM) or hypertension, parity, the residence of the mother and infant, infant sex, birth weight, Apgar score, and presence of congenital anomaly. The monthly PM 2.5 concentration from the first month of pregnancy to the delivery was computed based on the mothers' residences. Results PM 2.5 exposure concentration in the second trimester was higher in the congenital anomaly group than in the non-congenital anomaly group (24.82 ± 4.78 µg/m 3 , P = 0.023). PM 2.5 exposure concentration did not affect the incidence of nervous, cardiovascular, and gastrointestinal anomalies. While statistically insignificant, the groups with nervous, cardiovascular, gastrointestinal, musculoskeletal, and other congenital anomalies were exposed to higher PM 2.5 concentrations in the first trimester compared with their respective counterparts. The effect of PM 2.5 concentration on the incidence of congenital anomalies was significant even after adjusting for the mother's age, presence of DM, hypertension, and parity. The incidence of congenital anomalies increased by 26.0% (95% confidence interval of 4.3% and 49.2%) per 7.23 µg/m 3 elevation of PM 2.5 interquartile range in the second trimester. Conclusions The congenital anomaly group was exposed to a higher PM 2.5 concentration in the second trimester than the non-congenital anomaly group. The PM 2.5 exposure concentration level in the first trimester tended to be higher in groups with anomalies than those without anomalies. This suggests that continuous exposure to a high PM 2.5 concentration during pregnancy influences the incidence of neonatal anomalies in surgical respects.

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“…The effect modi cation was prominent in the ³65 years old group.Conclusions: We found a signi cantly increased risk of all-cause, respiratory, and cardiovascular mortality for daily PM 2.5 exposure when the day of high concentration began and the days lasted for more than 4 days with high concentration of ≥35 μg/m 3 . The elderly showed a stronger effect of persistently high PM 2.5 .Korean air pollution [13,14]. We used the Community Multiscale Air Quality (CMAQ, version 4.7.1) system with the AERO5 aerosol module, chemical mechanism, and the Statewide Air Pollution Research Center 99 (SAPRC99).…”

mentioning

confidence: 99%

“…Korean air pollution [13,14]. We used the Community Multiscale Air Quality (CMAQ, version 4.7.1) system with the AERO5 aerosol module, chemical mechanism, and the Statewide Air Pollution Research Center 99 (SAPRC99).…”

mentioning

confidence: 99%

Prolonged Short-Term Exposure To A High Concentration of Ambient Fine Particulate Matter And Effect Modification On Daily Mortality

Lim

Bae

Choi

et al. 2022

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Background: Although the evidence for the effect of short-term mortality is very high, epidemiologic studies on the effect of prolonged continuous exposure to high concentrations are rare. This study aimed to investigate how the size of the mortality effect of PM2.5 would be modified when a high concentration period persisted.Methods: We used daily mortality counts (ICD-10, non-traumatic all-cause: A00-R99, respiratory: J00-J98, and cardiovascular: I00-I99), simulated levels of daily PM2.5, measured daily mean temperature, and relative humidity data in seven metropolitan cities from 2006 to 2019. Generalized additive models (GAMs) with quasi-Poisson distribution in seven cities and random-effects meta-analyses to pool city-specific effects were used to examine the short-term effects of PM2.5. To investigate effect modification by continuous exposure to prolonged high concentrations, we applied categorical consecutive day variables to the GAMs as effect modification terms of PM2.5. Subgroup analyses were performed to examine the variation in effect modification according to the age group.Results: The mortality risk according to increase of 10 μg/m3 of PM2.5 concentration was increased by 0.30% (95%CI, 0.13–0.49), 0.48% (95%CI, -0.09–1.05), and 0.23% (95%CI, -0.10–0.57) based on the model with 0-1 lag day, for all-cause, respiratory, and cardiovascular diseases, respectively. The risk for all-cause mortality per 10 μg/m3 increase of PM2.5 in the first and fourth consecutive days were significantly increased by 0.61% (95%CI, 0.17–1.06) and 0.34% (95%CI, 0.03–0.65). The effect modification was prominent in the ³65 years old group.Conclusions: We found a significantly increased risk of all-cause, respiratory, and cardiovascular mortality for daily PM2.5 exposure when the day of high concentration began and the days lasted for more than 4 days with high concentration of ≥35 μg/m3. The elderly showed a stronger effect of persistently high PM2.5.

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Prenatal exposure to traffic-related air pollution and risk of congenital diseases in South Korea

Cited by 14 publications

References 49 publications

Maternal exposure to ambient air pollution and risk of congenital heart defects in Suzhou, China

Maternal exposure to ambient air pollution and risk of congenital heart defects in Suzhou, China

Correlation between Exposure to Fine Particulate Matter (PM_2.5) during Pregnancy and Congenital Anomalies: Its Surgical Perspectives

Prolonged Short-Term Exposure To A High Concentration of Ambient Fine Particulate Matter And Effect Modification On Daily Mortality

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Prenatal exposure to traffic-related air pollution and risk of congenital diseases in South Korea

Cited by 14 publications

References 49 publications

Maternal exposure to ambient air pollution and risk of congenital heart defects in Suzhou, China

Maternal exposure to ambient air pollution and risk of congenital heart defects in Suzhou, China

Correlation between Exposure to Fine Particulate Matter (PM2.5) during Pregnancy and Congenital Anomalies: Its Surgical Perspectives

Prolonged Short-Term Exposure To A High Concentration of Ambient Fine Particulate Matter And Effect Modification On Daily Mortality

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Correlation between Exposure to Fine Particulate Matter (PM_2.5) during Pregnancy and Congenital Anomalies: Its Surgical Perspectives