Prenatal exposure to tobacco and marijuana and child autonomic regulation and reactivity: An analysis of indirect pathways via maternal psychopathology and parenting

Schuetze, Pamela; Zhao, Jiupeng; Eiden, Rina D.; Shisler, Shannon; Huestis, Marilyn A.

doi:10.1002/dev.21844

Cited by 12 publications

(12 citation statements)

References 75 publications

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“…Tobacco is sometimes mixed not only with alcohol but also with narcotics; in particular the effect of prenatal combining tobacco with marijuana was studied. The study indicated an indirect association between this combination and autonomic functioning during the second year of life [ 60 ]. Similarly, a connection between prenatal cannabis exposure (mostly combined with tobacco) and cortical thickness was suggested [ 61 ].…”

Section: Resultsmentioning

confidence: 99%

Tobacco and Nervous System Development and Function—New Findings 2015–2020

et al. 2021

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Tobacco is a one of the most common addictive stimulants used by people around the world. The smoke generated during tobacco combustion is a toxic mixture of more than 5000 chemicals of which over 30 are known human carcinogens. While its negative effects on the human body are well understood, it remains a serious public health problem. One of the multiple effects of smoking is tobacco’s effect on the nervous system—its development and function. This review aims to summarize the progress made in research on the effects of tobacco on the nervous system both of the perinatal period and adults and both in animals and humans in 2015–2020. The 1245 results that corresponded to the keywords “tobacco, cigarette, nervous system, brain, morphology, function” were reviewed, of which 200 abstracts were considered significant. Most of those articles broadened the knowledge about the negative effects of smoking on the human nervous system. Tobacco has a significant negative impact on the development of nervous structures, neurotransmission and cognitive functions, and promotes the development of neurodegenerative diseases, insomnia and cerebrovascular diseases. The only exception is the protective effect of the dopaminergic system in Parkinson’s disease. In conclusion, in recent years much effort has been devoted to describing, revealing and uncovering new aspects of tobacco detrimental to human life. The nicotine contained in tobacco smoke affects the human body in a multidimensional way, including a serious impact on the broadly understood neurological health.

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Section: Resultsmentioning

confidence: 99%

Tobacco and Nervous System Development and Function—New Findings 2015–2020

et al. 2021

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“…In the current study, neither cool nor hot inhibitory control emerged as a mechanism accounting for the link between early tobacco smoke exposure and internalizing problems. Thus, future research is warranted to test alternative explanatory mechanisms, such as emotion regulation strategies, maternal psychopathology, and parenting (Margolis et al, 2016; Schuetze et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Among plausible psychological mechanisms, impaired self-regulation, especially inhibitory control, merits special attention (Clark, Massey, Wiebe, Espy, & Wakschlag, 2019; Wiebe et al, 2015). This proposition is based on numerous studies showing the implications of inhibitory control for psychopathology (Schoemaker, Mulder, Deković, & Matthys, 2013) and on accumulating evidence indicating that brain regions (e.g., prefrontal lobe) and neural systems (e.g., dopaminergic, serotonergic, and noradrenergic systems) variously implicated in self-regulatory activities are likely to be disrupted by early exposure to tobacco smoke (Holz et al, 2014; Lotfipour et al, 2009; Marroun et al, 2014; Schuetze, Zhao, Eiden, Shisler, & Huestis, 2019).…”

Section: Early Tobacco Smoke Exposure: Conceptualization and Developm...mentioning

confidence: 99%

“…Substance use during pregnancy and the postpartum period is not an isolated problem behavior, but rather likely to be a marker for a number of risk factors in different domains that may also be predictors of less optimal child outcomes. These factors primarily include: parental psychiatric and psychological factors (e.g., depression), parent–child shared genetic liability for psychopathology, sociodemographic factors (e.g., low socioeconomic status), perinatal factors (e.g., low birth weight), and exposure to other substances (e.g., alcohol; Godleski, Eiden, Schuetze, Colder, Huestis, 2016; Massey et al, 2016; Schuetze et al, 2019; Wakschlag et al, 2002). Although it is difficult to disentangle the effects of tobacco smoke exposure from the effects of related social and genetic factors, comprehensively controlling for potential confounding factors when examining the consequences of early exposure would decrease the likelihood of obtaining spurious results.…”

Section: Some Additional Issues When Addressing the Implications Of E...mentioning

confidence: 99%

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Early tobacco smoke exposure, preschool cool/hot inhibitory control, and young adolescents’ externalizing/internalizing problems.

Cao¹,

Liang²,

Zhou³

2021

Journal of Family Psychology

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There is a dearth of research spanning multiple developmental stages to delineate the far-reaching implications of early tobacco smoke exposure for later behavior adaptation and also elucidate the underlying psychological mechanisms. Using NICHD SECCYD data, we conducted process model analyses to address this gap. Results indicated that early tobacco smoke exposure was not only negatively associated with preschool cool and hot inhibitory control, but also positively related to externalizing and internalizing problems in early adolescence. Further, early exposure was also positively associated with externalizing problems in early adolescence via a negative link with preschool cool inhibitory control. Behavior problems in toddlerhood also served as one mechanism underlying the implications of early exposure for behavior problems in early adolescence. As compared to nonexposed children, children with both prenatal and postnatal exposure tended to have lower cool and hot inhibitory control, whereas children with only prenatal exposure displayed lower hot inhibitory control. Regardless of whether exposure was across prenatal and postnatal periods, or restricted to prenatal phase alone, exposed children displayed more behavior problems in toddlerhood, which in turn predicted more behavior problems in early adolescence. All associations emerged after considering extensive potential confounding factors and did not vary across child sex. Taken together, early tobacco smoke exposure may induce self-regulation deficits and also early onset of behavior problems and thus elevate the risk of later psychopathology. Building a smoke free environment in pregnancy and infancy likely yields long-term benefits by facilitating adaptation in early adolescence.

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“…Environmental risk factors account for significant variance in developmental outcomes among infants exposed to opioids prenatally (Konijnenberg & Melinder, 2011; Messinger et al., 2004). Parenting behaviors such as parental sensitivity and harshness may moderate or mediate the effects of prenatal substance exposure on developmental outcomes (Eiden et al., 2014; Flykt et al., 2021; Schuetze et al., 2019; Veira et al., 2014). Opioid‐exposed infants often exhibit autonomic dysregulation and are difficult to soothe (Kocherlakota, 2014).…”

Section: Introductionmentioning

confidence: 99%

Effects of an attachment‐based intervention on autonomic regulation among opioid‐exposed infants

Tabachnick

Eiden

Labella

et al. 2022

Developmental Psychobiology

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Little is known about whether postnatal intervention enhances autonomic regulation among infants at risk for dysregulation due to prenatal opioid exposure. The present study evaluated the effects of modified Attachment Behavioral Catch-up (mABC) on autonomic regulation for opioid-exposed infants in a pilot randomized clinical trial. We hypothesized that, compared to a control intervention (modified Developmental Education for Families [mDEF]), mABC would be associated with higher resting respiratory sinus arrhythmia (RSA) and pre-ejection period (PEP) as well as greater reactivity to and recovery from a social stressor (Still-Face Paradigm). Pregnant or peripartum women receiving opioid agonist therapy (61 mothers of 64 infants; final N = 36 infants) were randomly assigned to mABC or mDEF, 12-session home visiting programs beginning in the third trimester; mABC targets sensitive parenting, and mDEF targets cognitive and motor development. mABC was associated with significantly greater RSA reactivity and marginally greater PEP reactivity. In models accommodating missing data, mABC was additionally associated with significantly greater RSA recovery. In sensitivity analyses removing siblings, mABC predicted significantly enhanced PEP reactivity. Overall, in these preliminary analyses, mABC was associated with healthier autonomic regulation during a social stressor than mDEF. Thus, mABC may be a promising strategy to promote autonomic regulation among opioid-exposed infants through parenting intervention.

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Prenatal exposure to tobacco and marijuana and child autonomic regulation and reactivity: An analysis of indirect pathways via maternal psychopathology and parenting

Cited by 12 publications

References 75 publications

Tobacco and Nervous System Development and Function—New Findings 2015–2020

Tobacco and Nervous System Development and Function—New Findings 2015–2020

Early tobacco smoke exposure, preschool cool/hot inhibitory control, and young adolescents’ externalizing/internalizing problems.

Effects of an attachment‐based intervention on autonomic regulation among opioid‐exposed infants

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