Prenatal exposure to preeclampsia as an independent risk factor for long-term cardiovascular morbidity of the offspring

Sacks, Kira Nahum; Friger, Michael; Shoham‐Vardi, Ilana; Spiegel, Efrat; Sergienko, Ruslan; Landau, Daniella; Sheiner, Eyal

doi:10.1016/j.preghy.2018.06.013

Cited by 91 publications

(61 citation statements)

References 38 publications

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“…The current literature focuses on the adverse outcomes occurring during the pregnancy and shortly after, such as the increased risk of fetal growth restriction, 7,8 perinatal death, 9 and severe neonatal morbidity 10,11 . While recent studies have reported a correlation between pre‐eclampsia and long‐term cardiovascular 3,12–15 and neurological 16,17 effects on the offspring, less is known about the effect on the respiratory health of the offspring.…”

Section: Introductionmentioning

confidence: 99%

In utero exposure to pre‐eclampsia as an independent risk factor for long‐term respiratory disease

Sacks

Friger

Shoham‐Vardi

et al. 2020

Pediatric Pulmonology

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Introduction Pre‐eclampsia has a considerable effect on the intrauterine environment, yet not much is understood about how this impacts the respiratory health of the offspring. The aim of the present study is to determine if pre‐eclampsia correlates with a higher incidence of respiratory disease in the offspring. Methods This cohort study assessed the differences in respiratory disease patterns between singletons born to mothers with and without pre‐eclampsia. The study was conducted between 1991 and 2014 in a regional tertiary medical center. A generalized estimating equation (GEE) model was used to control for confounders and maternal clusters. Results 253 808 deliveries were included in the study. Of these, 3.0% were to mothers diagnosed with pre‐eclampsia (n = 7660), 0.9% with severe pre‐eclampsia (n = 2366), and 0.03% with eclampsia (n = 81). A significant linear association was noted between the severity of the pre‐eclampsia (no pre‐eclampsia, mild, severe pre‐eclampsia, and eclampsia) and respiratory disease of the offspring (5.7%, vs 6.0% vs 7.3% vs 9.9%, respectively; P = .003). The offspring of mothers who developed pre‐eclampsia had significantly higher rates of asthma (1.1%, vs 1.3% vs 1.4% vs 1.2% correspondingly; P = .018). In the GEE model, controlling for gestational diabetes, maternal age, gestational age, and length of follow up, pre‐eclampsia was found to be an independent risk factor for respiratory morbidity in the offspring (adjusted odds ratio = 1.32; 95% confidence interval, 1.21‐1.45). Conclusion Exposure to maternal pre‐eclampsia is an independent risk factor for long‐term respiratory morbidity in the offspring. Specifically, the prenatal exposure to pre‐eclampsia was significantly associated with asthma of the offspring.

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Section: Introductionmentioning

confidence: 99%

In utero exposure to pre‐eclampsia as an independent risk factor for long‐term respiratory disease

Sacks

Friger

Shoham‐Vardi

et al. 2020

Pediatric Pulmonology

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“…Nahum et al reported that offspring of preeclampsia were at higher risk of developing hypertension compared with normotensive pregnancy (incidence rate of hypertension: severe preeclampsia: 0.14; mild preeclampsia: 0.11; control: 0.06; p < 0.001). 22…”

Section: Cardiovascular Outcomes In Offspring Exposed To Preeclampsiamentioning

confidence: 99%

Lasting Effects of Intrauterine Exposure to Preeclampsia on Offspring and the Underlying Mechanism

2019

AJP Rep

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Preeclampsia is a common pregnancy complication which can have adverse impact on both mother and baby. In addition to the short term effects, a large body of epidemiological evidence has found preeclampsia can exert long-lasting effects on mother and offspring. Studies suggest that offspring exposed to preeclampsia are at a higher risk of developing cardiovascular, metabolic, and neurological diseases, as well as other diseases. However, studies investigating the underlying mechanism are limited, the exact mechanism still remains unclear. In this study, we will review the epidemiological evidence and studies exploring the mechanism underlying long-term effects of preeclampsia on offspring. Further studies should be targeted at this field so as to implement effective clinical management to prevent the exposed offspring from potential diseases.

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“…Human biologists have long been interested in understanding the pathways by which early life experience—including in utero—can impact future health outcomes (eg, metabolic and cardiovascular disease later in life), especially if experienced during key developmental periods (Kuzawa & Quinn, 2009). Pregnancy represents an especially vulnerable period, with women at an increased risk for developing mood disorders (eg, depression) and health conditions (eg, gestational diabetes, preeclampsia) that can impair longer‐term mental and physical health (Bauer, Knapp, & Parsonage, 2016; Damm et al, 2016; Nahum Sacks et al, 2018). Moreover, evidence indicates that adverse conditions experienced during pregnancy—such as high levels of psychosocial stress—are linked with increased risk of negative birth outcomes (Aizer, Stroud, & Buka, 2016; Kinsella & Monk, 2009; Nepomnaschy et al, 2006; Pike, 2005; Thayer, Bécares, & Atatoa Carr, 2019).…”

Section: Introductionmentioning

confidence: 99%

Maternal and child health during the COVID‐19 pandemic: Contributions in the field of human biology

Gildner

Thayer

2020

American J Hum Biol

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Prenatal exposure to preeclampsia as an independent risk factor for long-term cardiovascular morbidity of the offspring

Cited by 91 publications

References 38 publications

In utero exposure to pre‐eclampsia as an independent risk factor for long‐term respiratory disease

In utero exposure to pre‐eclampsia as an independent risk factor for long‐term respiratory disease

Lasting Effects of Intrauterine Exposure to Preeclampsia on Offspring and the Underlying Mechanism

Maternal and child health during the COVID‐19 pandemic: Contributions in the field of human biology

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