Prenatal exposure to polycyclic aromatic hydrocarbons and effects on neonatal anthropometric indices and thyroid-stimulating hormone in a Middle Eastern population

Dehghani, Samaneh; Fararouei, Mohammad; Rafiee, Ata; Hoepner, Lori; Oskoei, Vahide; Hoseini, Mohammad

doi:10.1016/j.chemosphere.2021.131605

Cited by 40 publications

(14 citation statements)

References 63 publications

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“…It has recently been shown that maternal exposure to PAHs is associated with a 6.8% reduction in body weight and a 3% reduction in head circumference at birth, and reduced white matter surface of the left hemisphere in childhood (Yi et al, 2022). It is well known that PAHs easily penetrate the placental barrier and cause fetal defects in humans and various animal species (Dehghani et al, 2022; Webb et al, 2018). PAHs cause toxic effects on humans and organisms through different mechanisms.…”

Section: Discussionmentioning

confidence: 99%

Protective effect of quercetin on fetal development and congenital skeletal anomalies against exposure of pregnant Wistar rats to crude oil vapor

Hussein,

Khazaeel,

Ranjbar

et al. 2023

Birth Defects Research

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BackgroundEpidemiological evidence indicates a relationship between maternal exposure to crude oil vapors (COV) during pregnancy and adverse pregnancy outcomes. Quercetin (QUE) is a plant flavonoid with purported antioxidant and anti‐inflammatory effects, which has been shown to prevent birth defects. This study was aimed to investigate the protective role of QUE on fetal development and congenital skeletal anomalies caused by exposure of pregnant rats to COV.MethodsTwenty‐four pregnant Wistar rats were randomly categorized into four groups of control, COV, COV + QUE, and QUE (50 mg/kg). The inhalation method was used to expose pregnant rats to COV from day 0 to 20 of pregnancy, and QUE was administered orally during this period. On day 20 of gestation, the animals were anesthetized and a laparotomy was performed, and then the weight and crown rump length (CRL) of the fetuses were determined. Skeletal stereomicroscopic evaluations of fetuses were performed using Alcian blue/Alizarin red staining method, and the expression of osteogenesis‐related genes (Runx2 and BMP‐4) was evaluated using qPCR.ResultsThis study showed that prenatal exposure to COV significantly reduced fetal weight and CRL, and expression of Runx2 and BMP‐4 genes. Moreover, COV significantly increased the incidence of congenital skeletal anomalies such as cleft palate, spina bifida and non‐ossification of the fetal bones. However, administration of QUE with exposure to COV improved fetal bone development and reduced congenital skeletal anomalies.ConclusionQUE can ameliorate the teratogenic effects of prenatal exposure to COV by increasing the expression of osteogenesis‐related genes.

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Section: Discussionmentioning

confidence: 99%

Protective effect of quercetin on fetal development and congenital skeletal anomalies against exposure of pregnant Wistar rats to crude oil vapor

Hussein,

Khazaeel,

Ranjbar

et al. 2023

Birth Defects Research

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“…This paper is pioneering in attempting to apply the RD design to infer the causal relationship between APCs and dementia, and accordingly, provides several meaningful insights for future research as follows (a) more cross-national studies based on the RD designs are extremely meaningful, especially in comparing the heterogeneous effects of APCs on the dementia between developing and developed countries and (b) future research needs to pay more attention to reveal the potential correlation between APCs and dementia, In particular, whether impairments in cardiorespiratory function or changes in brain structure are indirectly involved as mediating variables in the association between the APCs and dementia (Dehghani et al 2022 ), needs to be discussed farther and (c) it would be worthwhile to investigate how to methodologically implement a cross-level RD design, as air pollutant concentrations tend to be a city-level variable and dementia tends to be an individual-level variable, if the HLM can be combined with the RD design, it will help to isolate the net effects between APCs and dementia.…”

Section: Discussionmentioning

confidence: 99%

Is there a casual relation between air pollution and dementia?

Xie

2022

Environ Sci Pollut Res

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Dementia has been cited as a critical public health risk in the contemporary world, while few empirical researchers try to reveal the casual relationship between air pollutant concentrations (APCs) and dementia, especially given the increasing prevalence of air pollution on a global scale. Accordingly, this paper tries to infer the causal relationship between APCs and dementia. The 59,605 valid data was compiled through a combination of the statistic from the China Family Panel Study, China Environmental Statistics Yearbook, World Meteorological Association and China National Bureau of Statistics. The RD design of this study utilizes the discontinuous variation in APCs and dementia as one crosses the Huai River boundary, which is an arbitrary heating policy that causes the significant difference in APCs between the north and south of China. We used stata17.0 to analyze the data. The results of the RD regression indicated that a 100 μ g/ m 3 rise in APCs led to an increase of 42.4% in the hazard ratio of suffering dementia (Coeff=-0.58, SD= 0.23, P < 0.05). Meanwhile, heterogeneous models revealed that the hazard ratio of suffering dementia by APCs was more significant in the older compared to younger (coeff= 1.35 vs coeff= 1.55, P < 0.05), male compared to female (coeff= 1.62 vs coeff= 0.71, P < 0.05), smoking compared to non-smoke (coeff= 2.12 vs coeff= 0.93, P < 0.05), and thin groups compared to medium and obesity (coeff= 2.05 vs coeff= 1.22, coeff= 1.28, P < 0.05). In addition, the O3 and SO2 were the air pollutants with the highest (coeff= 1.54, P < 0.05) and lowest effects (coeff= 0.81, P < 0.05) on the hazard ratio of suffering dementia among the five APCs, respectively. And the robustness of the results was ensured by changing the RD bandwidth, polynomial order. The results indicated that APCs significantly induced the hazard ratio of suffering dementia of Chinese residents, which provides empirical evidence in supporting the Chinese government to invest more in combating air pollution and ensure the public health of Chinese residents.

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“…16 Because the AHR signaling pathway is essential to regulate the immune system function, cell cycle growth and regulation, and reproductive system regulation, 17 interactions between the AHR and hormone signaling pathways, including thyroid hormone signaling pathways, have demonstrated the involvement of PAHs in the mechanisms underlying endocrine disorders. 18 Chronic exposure to PAHs may induce deoxyribonucleic acid (DNA) adduct formation in vitro and in vivo , where the formation of DNA adducts is a key event in PAH mutagenicity and carcinogenicity. 4 Exposure to PAHs may have been linked to jaundice, kidney and liver damage, reduced lung function, cataracts, and skin inflammation and redness.…”

Section: Introductionmentioning

confidence: 99%

Association of exposure to polycyclic aromatic hydrocarbons with thyroid hormones in adolescents and adults, and the influence of the iodine status

Yang

Sun

Wang

et al. 2023

Environ. Sci.: Processes Impacts

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Prenatal exposure to polycyclic aromatic hydrocarbons and effects on neonatal anthropometric indices and thyroid-stimulating hormone in a Middle Eastern population

Cited by 40 publications

References 63 publications

Protective effect of quercetin on fetal development and congenital skeletal anomalies against exposure of pregnant Wistar rats to crude oil vapor

Protective effect of quercetin on fetal development and congenital skeletal anomalies against exposure of pregnant Wistar rats to crude oil vapor

Is there a casual relation between air pollution and dementia?

Association of exposure to polycyclic aromatic hydrocarbons with thyroid hormones in adolescents and adults, and the influence of the iodine status

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