Prenatal exposure to polybrominated diphenyl ethers and predisposition to frustration at 7 months: Results from the MIREC study

Oulhote, Youssef; Tremblay, Émilie; Arbuckle, Tye E.; Fraser, William D.; Lemelin, Jean‐Pascal; Séguin, Jean R.; Ouellet, Emmanuel; Forget‐Dubois, Nadine; Ayotte, Pierre; Boivin, Michel; Dionne, Ginette; Lanphear, Bruce P.; Muckle, Gina

doi:10.1016/j.envint.2018.06.010

Cited by 15 publications

(10 citation statements)

References 49 publications

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“…An increasing number of studies have reported that newborn and fetal exposure to organochlorinated and/or brominated chemicals might have adverse effects on humans and wildlife. Prenatal exposure to PBDEs was associated with cognitive deficits and behavioral problems in children . Additionally, gestation period exposure to PBDEs would delay neuro ontogeny, alter motor activity, and reduce performance on learning and habituation tasks in mice .…”

Section: Resultsmentioning

confidence: 99%

“…Prenatal exposure to PBDEs was associated with cognitive deficits and behavioral problems in children. 74 Additionally, gestation period exposure to PBDEs would delay neuro ontogeny, alter motor activity, and reduce performance on learning and habituation tasks in mice. 75 Similarly, maternal exposure to high levels of contaminants may pose adverse effects to the calf dolphins, including endocrine disruption and neurotoxicity.…”

Section: Pbde Concentrations Inmentioning

confidence: 99%

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Long-Term Monitoring of Polybrominated Diphenyl Ethers (PBDEs) in Indo-Pacific Humpback Dolphins (Sousa chinensis) from the Pearl River Estuary Reveals High Risks for Calves due to Maternal Exposure

Xie

Gui

2022

Environ. Sci. Technol.

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Although many studies have documented the wide occurrence of polybrominated diphenyl ethers (PBDEs) in cetaceans, little evidence exists regarding the detrimental effects of PBDE exposure on calf death rates for freeranging cetaceans. This study analyzed life-history-associated PBDE bioaccumulation patterns in 128 stranding Indo-Pacific humpback dolphin (Sousa chinensis) samples over an 18-year timespan from the Pearl River Estuary (PRE). In comparison to the records of PBDE levels in cetaceans worldwide, the median levels of PBDEs (median = 10600 ng g −1 lw, range = 721−50900 ng g −1 lw) in all samples were the highest to date. One-way analysis of variance (ANOVA) showed that adult males (median = 16100 ng g −1 lw, range = 4070−50900 ng g −1 lw) and calves (12000 ng g −1 lw, range = 1250−35300 ng g −1 lw) both had the highest levels of PBDEs compared to the rest of the age/sex groups (p < 0.05). Concentrations of PBDEs in noncalves significantly decreased over the studied period, while those in calves had a slightly increasing trend, which may be due to different exposure routes via fish or milk, respectively. A significant and positive relationship was found between annual calf stranding death rates and body-length-adjusted PBDE concentrations in calves (r = 0.62, p < 0.05), suggesting that maternal exposure of calves to elevated levels of PBDEs may have contributed to the high annual stranding death rates of calves in the last two decades.

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Section: Resultsmentioning

confidence: 99%

Section: Pbde Concentrations Inmentioning

confidence: 99%

Long-Term Monitoring of Polybrominated Diphenyl Ethers (PBDEs) in Indo-Pacific Humpback Dolphins (Sousa chinensis) from the Pearl River Estuary Reveals High Risks for Calves due to Maternal Exposure

Xie

Gui

2022

Environ. Sci. Technol.

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“…Details about eligibility and exclusion criteria are outlined by Arbuckle et al 32 At age 36-48 months, a subset of 610 participating children in six cities were included in a follow-up study in which researchers assessed neurodevelopment. 3,[34][35][36] We restricted our study to 517 mother-child pairs from this group based on the availability of biomarkers and intelligence quotient (IQ) scores. 33,35,36 The MIREC study received ethics approval from Health Canada and the Institutional Review Board of CHU Sainte-Justine Research Centre, as well as all recruitment centers.…”

Section: Study Participantsmentioning

confidence: 99%

Using Latent Profile Analysis to Identify Associations Between Gestational Chemical Mixtures and Child Neurodevelopment

et al. 2022

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Background: Unsupervised machine learning techniques have become increasingly popular for studying associations between gestational exposure mixtures and human health. Latent profile analysis is one method that has not been fully explored. Methods: We estimated associations between gestational chemical mixtures and child neurodevelopment using latent profile analysis. Using data from the Maternal-Infant Research on Environmental Chemicals (MIREC) research platform, a longitudinal cohort of pregnant Canadian women and their children, we generated latent profiles from 27 gestational exposure biomarkers. We then examined the associations between these profiles and child Verbal IQ, Performance IQ, and Full-Scale IQ, measured with the Wechsler Preschool and Primary Scale of Intelligence, Third Edition (WPPSI-III). We validated our findings using k-means clustering. Results: Latent profile analysis detected five latent profiles of exposure: a reference profile containing 61% of the study participants, a high monoethyl phthalate (MEP) profile with moderately low persistent organic pollutants (POPs) containing 26%, a high POP profile containing 6%, a low POP profile containing 4%, and a smoking chemicals profile containing 3%. We observed negative associations between both the smoking chemicals and high MEP profiles and all IQ scores and between the high POP profile and Full-Scale and Verbal IQ scores. We also found a positive association between the low POP profile and Full-Scale and Performance IQ scores. All associations had wide 95% confidence intervals. Conclusions: Latent profile analysis is a promising technique for identifying patterns of chemical exposure and is worthy of further study for its use in examining complicated exposure mixtures.

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“…Plusieurs études de cohortes mère-enfant traitant du lien entre l'exposition aux PBDE qui débute in utero et les troubles du neurodéveloppement ont été publiées depuis 2009 (5)(6)(7)(8)(9)(10)(11)(12)(13)(14)(15)(16) dans différents pays (Europe, Chine, Etats-Unis, Canada). Elles sont présentées dans le tableau 1.…”

Section: Données éPidémiologiquesunclassified

Polluants in materials of everyday life and neurodevelopment in children

Etiemble¹,

Cordier²

2022

Environnement Risques Santé

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L'exposition à des polluants présents à faibles concentrations dans les matériaux de la vie quotidienne (retardateurs de flamme, composés perfluorés, bisphénols, phtalates), considérés comme des perturbateurs endocriniens, a été associée à des perturbations du neurodéveloppement chez l'enfant dans des études prospectives. La force de l'association varie selon les substances, les différents congénères et les métabolites. La période prénatale représente la période de vulnérabilité pendant laquelle les substances peuvent altérer la trajectoire développementale du cerveau. Des associations sont mises en évidence dans les études avec des altérations psychomotrices, cognitives et comportementales : principalement dans le domaine cognitif avec les retardateurs de flamme ; dans le domaine comportemental avec les phtalates et les bisphénols. Les effets associés aux expositions sont plus fréquents chez les garçons, les filles sont concernées surtout avec les bisphénols. L'implication de ces substances dans la prévalence des troubles du spectre autistique (TSA) et du trouble déficit d'attention/hyperactivité (TDAH) reste incertaine. Des effets sur le comportement et les capacités d'apprentissage sont décrits dans les études expérimentales. La modification de l'homéostasie des hormones thyroïdiennes est une des hypothèses pouvant expliquer les effets comme perturbateurs endocriniens mais des interactions avec d'autres systèmes hormonaux et de neurotransmission peuvent également perturber les différents processus neurodéveloppementaux selon le sexe. Des modifications épigénétiques de l'expression de gènes essentiels au développement du cerveau sont associées à l'exposition à ces polluants.

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Prenatal exposure to polybrominated diphenyl ethers and predisposition to frustration at 7 months: Results from the MIREC study

Abstract: Prenatal exposure to PBDEs was associated with increased incidence of crying and screaming with delayed onset of discomfort movement, which may indicate a predisposition to frustration and lack of habituation in infants younger than 12 months from the general population.

Cited by 15 publications

References 49 publications

Long-Term Monitoring of Polybrominated Diphenyl Ethers (PBDEs) in Indo-Pacific Humpback Dolphins (Sousa chinensis) from the Pearl River Estuary Reveals High Risks for Calves due to Maternal Exposure

Long-Term Monitoring of Polybrominated Diphenyl Ethers (PBDEs) in Indo-Pacific Humpback Dolphins (Sousa chinensis) from the Pearl River Estuary Reveals High Risks for Calves due to Maternal Exposure

Using Latent Profile Analysis to Identify Associations Between Gestational Chemical Mixtures and Child Neurodevelopment

Polluants in materials of everyday life and neurodevelopment in children

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Prenatal exposure to polybrominated diphenyl ethers and predisposition to frustration at 7 months: Results from the MIREC study

Abstract: Prenatal exposure to PBDEs was associated with increased incidence of crying and screaming with delayed onset of discomfort movement, which may indicate a predisposition to frustration and lack of habituation in infants younger than 12 months from the general population.

Cited by 15 publications

References 49 publications

Long-Term Monitoring of Polybrominated Diphenyl Ethers (PBDEs) in Indo-Pacific Humpback Dolphins (Sousa chinensis) from the Pearl River Estuary Reveals High Risks for Calves due to Maternal Exposure

Long-Term Monitoring of Polybrominated Diphenyl Ethers (PBDEs) in Indo-Pacific Humpback Dolphins (Sousa chinensis) from the Pearl River Estuary Reveals High Risks for Calves due to Maternal Exposure

Using Latent Profile Analysis to Identify Associations Between Gestational Chemical Mixtures and Child Neurodevelopment

Polluants in materials of everyday life and neurodevelopment in children

Contact Info

Product

Resources

About

Prenatal exposure to polybrominated diphenyl ethers and predisposition to frustration at 7 months: Results from the MIREC study

Abstract: Prenatal exposure to PBDEs was associated with increased incidence of crying and screaming with delayed onset of discomfort movement, which may indicate a predisposition to frustration and lack of habituation in infants younger than 12 months from the general population.