Prenatal exposure to phthalates and neuropsychological development during childhood

Gascón, Mireia; Valvi, Damaskini; Forns, Joan; Casas, Maribel; Martínez, David; Júlvez, Jordi; Monfort, Núria; Ventura, Rosa; Sunyer, Jordi; Vrijheid, Martine

doi:10.1016/j.ijheh.2015.05.006

Cited by 90 publications

(68 citation statements)

References 32 publications

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“…Therefore, we cannot rule out the possibility of exposure misclassification. Further, a study done by Gascon et al (2015) demonstrated that phthalate exposure assessed using multiple urine measurements did not adversely affect children’s cognitive or psychomotor development. However, products containing phthalates are used continuously and we have demonstrated that ICCs from spot urine samples for some phthalate metabolites are fairly high (e.g., 0.77 for MBzP, where we see the strongest associations between exposure and novelty preference scores among girls).…”

Section: Discussionmentioning

confidence: 98%

Maternal prenatal urinary phthalate metabolite concentrations and visual recognition memory among infants at 27 weeks

Ipapo

Factor-Litvak

Whyatt

et al. 2017

Environmental Research

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Background Prior research has demonstrated inverse associations between maternal prenatal urinary phthalate metabolite concentrations and cognitive development assessed in preschool and school-aged children. While there are a limited number of studies that evaluated these associations during infancy, no study has evaluated whether these associations exist when using the Fagan Test of Infant Intelligence (FTII), which captures novelty preference as a function of visual recognition memory. Objective We evaluated associations between phthalate metabolite concentrations in maternal prenatal urine and cognition in infancy using the FTII at 27 weeks and determine if these associations are sex-specific. Methods Mono-n-butyl phthalate (MnBP), monobenzyl phthalate (MBzP), monoisobutyl phthalate (MiBP), mono-ethyl phthalate (MEP), mono-3-carboxypropyl phthalate (MCPP) and four di-2-ethylhexyl phthalate metabolites (DEHP) were quantified in urine samples collected from 168 minority women living in urban neighborhoods during their third trimester of pregnancy. The FTII was administered to infants at 27 weeks to measure visual recognition memory and was recorded as the novelty preference score. Results There were no associations between prenatal phthalate metabolite concentrations and novelty preference score in the full sample. However, there was evidence of effect modification by infant sex. Sex-stratified models demonstrated that compared to girls in the lowest tertile of MBzP concentrations, girls in tertiles 2 and 3 had, on average, 3.98 and 4.65 points lower novelty preference scores (p-value = 0.04 and 0.03, respectively). The relationship was similar for ΣDEHP, MiBP, and MEP. Effects among boys were inconsistent and generally not significant. Conclusion Maternal prenatal exposure to some phthalates was negatively associated with visual recognition memory as measured by the FTII among girls at age 27 weeks.

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Section: Discussionmentioning

confidence: 98%

Maternal prenatal urinary phthalate metabolite concentrations and visual recognition memory among infants at 27 weeks

Ipapo

Factor-Litvak

Whyatt

et al. 2017

Environmental Research

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“…Our study of primiparous urban women adds to the growing number of observational studies of prenatal phthalate exposure and cognitive development in young children (Whyatt et al 2012; Polanska et al 2014; Tellez-Rojo et al 2013; Gascon et al 2015). With few exceptions, investigators who reported results for girls and boys separately generally observed weakly negative associations among girls and null or weakly positive associations among boys.…”

Section: Discussionmentioning

confidence: 99%

“…To date, several epidemiologic studies have investigated the relationship between prenatal exposure to phthalates and child cognitive (Factor-Litvak et al 2014; Whyatt et al 2012; Polanska et al 2014; Tellez-Rojo et al 2013; Kim et al 2011) and behavioral (Whyatt et al 2012; Engel et al 2010; Swan et al 2010; Lien et al 2015; Gascon et al 2015; Kobrosly et al 2014) development. These studies suggest potential neurodevelopmental consequences of prenatal phthalate exposures, though there has been limited overlap in the neurodevelopmental outcomes assessed and child ages included across studies.…”

Section: Introductionmentioning

confidence: 99%

Prenatal phthalate biomarker concentrations and performance on the Bayley Scales of Infant Development-II in a population of young urban children

Doherty

Engel

Buckley

et al. 2017

Environmental Research

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Introduction Evidence suggests prenatal phthalate exposures may have neurodevelopmental consequences. Our objective was to investigate prenatal exposure to phthalates and cognitive development in a cohort of young urban children. Materials and Methods We recruited pregnant women in New York City from 1998 to 2002 and measured concentrations of nine phthalate metabolites in urine collected in late pregnancy. We administered a neurodevelopmental screening instrument, the Bayley Scales of Infant Development II (BSID-II), to children who returned for follow-up at approximately 24 months (n=276). We estimated associations between phthalate metabolite concentrations in maternal urine and BSID-II indices (Mental Development Index (MDI), Psychomotor Development Index (PDI)). Results We observed no associations between phthalate metabolite concentrations and performance on the MDI or PDI in boys and girls combined. We did, however, observe evidence of effect measure modification by sex. We observed several negative associations between metabolite concentrations and both MDI and PDI scores among girls, suggesting poorer performance across multiple metabolites, with estimates equal to a 2-3 point decrease in score per ln-unit increase in creatinine-standardized metabolite concentration. Conversely, we observed multiple weakly positive associations among boys, equal to a 1-2 point increase in score per ln-unit increase in metabolite concentration. The strongest associations were for the metabolites mono-n-butyl phthalate, monoisobutyl phthalate, monobenzyl phthalate, and mono(3-carboxylpropyl) phthalate (MCPP). Conclusions Girls of mothers with higher urinary concentrations of MCPP and metabolites of dibutyl phthalates had lower MDI scores on the BSID-II. These same biomarker concentrations were often associated with improved scores among boys. We observed similar results for MnBP, MCPP, and MBzP on the PDI. Given the prevalence of phthalate exposures in reproductive aged women, the implications of potential neurotoxicity warrant further investigation.

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“…3,63 It is important to note that three other publications did not find associations between prenatal phthalate exposure and child neurobehavior. 64–66 …”

Section: Phthalatesmentioning

confidence: 99%

Early-life exposure to EDCs: role in childhood obesity and neurodevelopment

2016

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Endocrine disrupting chemicals (EDCs) may increase the risk of childhood diseases by disrupting hormonally mediated processes critical for growth and development during gestation, infancy, or childhood. The fetus, infant, and child may have enhanced sensitivity to environmental stressors like EDCs due to rapid development and greater exposure to some EDCs that results from their developmentally appropriate behavior, anatomy, and physiology. This review summarizes epidemiological studies examining the relations of early-life exposure to bisphenol A (BPA), phthalates, triclosan, and perfluoroalkyl substance (PFAS) with childhood neurobehavioral disorders and obesity. The available epidemiological evidence suggests that prenatal exposure to several of these ubiquitous EDCs is associated with adverse neurobehavior (BPA and phthalates) and excess adiposity or increased risk of obesity/overweight (PFAS). Quantifying the effects of EDC mixtures, improving EDC exposure assessment, reducing bias from confounding, identifying periods of heightened vulnerability, and elucidating the presence and nature of sexually dimorphic EDC effects would result in stronger inferences from epidemiological studies. Ultimately, better estimates of the causal effects of EDC exposures on child health could help identify susceptible sub-populations and lead to public health interventions to reduce these exposures.

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Prenatal exposure to phthalates and neuropsychological development during childhood

Cited by 90 publications

References 32 publications

Maternal prenatal urinary phthalate metabolite concentrations and visual recognition memory among infants at 27 weeks

Maternal prenatal urinary phthalate metabolite concentrations and visual recognition memory among infants at 27 weeks

Prenatal phthalate biomarker concentrations and performance on the Bayley Scales of Infant Development-II in a population of young urban children

Early-life exposure to EDCs: role in childhood obesity and neurodevelopment

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