Prenatal Exposure to Perfluoroalkyl Substances and Birth Outcomes; An Updated Analysis from the Danish National Birth Cohort

Meng, Qi; Inoue, Kosuke; Ritz, Beate; Olsen, Jørn; Liew, Zeyan

doi:10.3390/ijerph15091832

Cited by 100 publications

(96 citation statements)

References 53 publications

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“…Outside of the ALSPAC cohort, our weakly inverse or null results are consistent with those reported in other epidemiologic studies of PFAS and birth size. The PFAS concentrations in this study are generally similar to levels reported in previous studies (Apelberg et al, 2007b;Ashley-Martin et al, 2017;Chen et al, 2012;Fei et al, 2007;Hamm et al, 2010;Manzano-Salgado et al, 2017;Meng et al, 2018;Minatoya et al, 2017;Sagiv et al, 2018;Shoaff et al, 2018;Starling et al, 2017;Whitworth et al, 2012;Woods et al, 2017), though PFNA is lowest in the present study. Studies from Japan (n = 168) (Minatoya et al, 2017), the United States (Maryland) (n = 299) (Apelberg et al, 2007b), Denmark (n = 1,400) (Fei et al, 2007), and Taiwan (n = 429) (Chen et al, 2012) have found evidence of inverse associations of PFOA and PFOS with birth size.…”

Section: Discussionsupporting

confidence: 92%

“…The epidemiological literature on prenatal PFAS exposure and birth size (birth weight, birth length, and head circumference) has been mixed, with some studies finding that higher concentrations are associated with reduced birth size (Apelberg et al, 2007b;Chen et al, 2012;Fei et al, 2007;Maisonet et al, 2012;Meng et al, 2018;Minatoya et al, 2017;Sagiv et al, 2018;Starling et al, 2017), while others observe largely null associations (Ashley-Martin et al, 2017;Hamm et al, 2010;Manzano-Salgado et al, 2017;Shoaff et al, 2018;Whitworth et al, 2012;Woods et al, 2017), with inconsistent results across PFAS chemicals. To date, studies of PFAS exposure and birth size have been conducted in American, Canadian, Danish, Norwegian, Spanish, Japanese, and Taiwanese populations.…”

Section: Introductionmentioning

confidence: 99%

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Maternal serum concentrations of perfluoroalkyl substances and birth size in British boys

Marks

Cutler

Jeddy

et al. 2019

International Journal of Hygiene and Environmental Health

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Per-and polyfluoroalkyl substances (PFAS) have been widely used in commercial and industrial manufacturing processes since the 1950s. Inverse associations between prenatal exposure to PFAS and birth size have been found in populations around the globe. This study examined the association of prenatal maternal serum concentrations of perfluorooctane sulfonic acid (PFOS), perfluorooctanoic acid (PFOA), perfluorohexane sulfonic acid (PFHxS), and perfluorononanoic acid (PFNA) and birth size in British boys. The study included 457 mother-son dyads participating in the Avon Longitudinal Study of Parents and Children (ALSPAC). Birth weight (g), crown to heel length (cm), and head circumference (cm) were collected at delivery. PFAS were detected in all maternal serum samples during pregnancy (median: 30 weeks gestation (interquartile range: 12-33)). Median concentrations (interquartile range) were 13.8 ng/mL (11.0, 17.7), 3.0 ng/mL (2.3, 3.8), 1.9 ng/mL (1.4, 2.5), and 0.4 ng/mL (0.3, 0.5) for PFOS, PFOA, PFHxS, and PFNA, respectively. In multivariable linear regression models, inverse associations were detected between PFOS (continuous) and birth weight (β = −8.50 g, 95% CI = −15.93, − 1.07 g), crown to heel length (β = −0.04 cm, 95% CI = −0.08, −0.01 cm), and head circumference (β = − 0.02 cm, 95% CI = − 0.04, −0.002 cm). In conclusion, prenatal exposure to high levels of PFOS may be associated with reduced birth size in male infants.The following PFAS were included in this analysis: PFOA, PFOS, PFHxS, and PFNA. Maternal serum samples were collected at median 30 weeks gestation (interquartile range (IQR): 12-33 weeks). Maternal serum samples were held in storage facilities at the University of Bristol until they were transferred under controlled conditions to the National Center for Environmental Health (NCEH) of the Centers for Disease Control and Prevention Marks et al.

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Section: Discussionsupporting

confidence: 92%

Section: Introductionmentioning

confidence: 99%

Maternal serum concentrations of perfluoroalkyl substances and birth size in British boys

Marks

Cutler

Jeddy

et al. 2019

International Journal of Hygiene and Environmental Health

View full text Add to dashboard Cite

show abstract

“…In the present study, we also found significant associations between BW and three additional PFASs (PFNA, PFDA, and PFUnDA). Exposure to these three compounds is substantial, 16,19,20 but they are still much less studied compared with PFOA and PFOS, and previous studies were, with a few exceptions, 11,19,21 small sized. The findings have been inconsistent, [19][20][21][22][23] with indications of slightly lower BW after higher prenatal exposures in only a few studies.…”

Section: Discussionmentioning

confidence: 99%

“…As part of the assessments of the mechanisms behind the effects of PFASs on BW, epidemiological associations of lower BW primarily via shorter pregnancies must also be ruled out. 11 The aim of the present study was therefore to evaluate the association between early pregnancy exposure to eight PFAS compounds and BW in the Swedish Environmental Longitudinal, Mother and child, Asthma and allergy (SELMA) study, specifically focusing on differences according to the sex of the child.…”

Section: Introductionmentioning

confidence: 99%

Maternal serum levels of perfluoroalkyl substances in early pregnancy and offspring birth weight

et al. 2019

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BACKGROUND: Perfluoroalkyl substances (PFASs) are widespread, bioaccumulating, and persistent and show placental transfer. Emerging research indicates associations between prenatal exposure and low birth weight. The aim of this study was to assess the associations between first trimester exposure to PFASs and birth weight (BW) in the Swedish Environmental, Longitudinal, Mother and child, Asthma and allergy (SELMA) study and examine whether associations differ between girls and boys. METHODS: Eight PFASs were analyzed in maternal serum (median: 10 weeks of pregnancy). Associations between prenatal PFAS exposure and birth outcomes with BW, BW for gestational age, and birth small for gestational age (SGA) were assessed in 1533 infants, adjusted for potential confounders and stratified by sex. RESULTS: Increased maternal perfluorooctane sulfonate (PFOS), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnDA) were associated with lower BW, lower BW for gestational age, and SGA birth. Associations were significant only in girls, where prenatal exposure in the upper quartile was associated with a 93-142-g lower BW when compared with that of the lowest quartile exposure. The associations were not mediated by effects on gestational age. CONCLUSIONS: We found associations between prenatal exposure for five different PFASs and birth weight, with more pronounced associations in girls than in boys.

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“…In humans, considerable amounts of PFAS from the mothers can cross the placental barrier and accumulate in the fetus (Fei et al 2007;Manzano-Salgado et al 2015). Numerous epidemiological studies have suggested that prenatal PFAS exposure might affect fetal growth (Bjerregaard-Olesen et al 2019;Fei et al 2008;Liew et al 2018a) and increase risk for preterm birth (Meng et al 2018).…”

Section: Introductionmentioning

confidence: 99%

Maternal Plasma Perfluoroalkyl Substances and Miscarriage: A Nested Case–Control Study in the Danish National Birth Cohort

Liew

Luo

Nøhr

et al. 2020

Environ Health Perspect

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BACKGROUND: Per-and polyfluoroalkyl substances (PFAS) are widespread persistent organic pollutants and endocrine disruptors. High doses of perfluorooctanesulfonic acid (PFOS) and perfluorooctanoic acid (PFOA) exposure can cause pregnancy loss and infant deaths in animals, but the associations between PFAS exposures and risk of miscarriage in humans are not well studied. METHODS: Using a case-control study nested within the Danish National Birth Cohort (DNBC, 1996-2002), we compared 220 pregnancies ending in miscarriage during weeks 12-22 of gestation, with 218 pregnancies resulting in live births. Levels of seven types of PFAS [PFOS, PFOA, perfluorohexane sulfonate (PFHxS), perfluoroheptane sulfonate (PFHpS), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluorooctanesulfonic acid (PFOSA)] were measured in maternal plasma collected in early gestation (mean gestational week 8). We estimated the odds ratios (ORs) and 95% confidence intervals (CIs) for miscarriage and each PFAS as a continuous variable or in quartiles, controlling for maternal age, parity, socio-occupational status, smoking and alcohol intake, gestational week of blood sampling, and maternal history of miscarriage. Stratification by parity and PFAS mixture analyses using weighted quantile sum (WQS) regression were also conducted. RESULTS: We observed a monotonic increase in odds for miscarriage associated with increasing PFOA and PFHpS levels. The ORs comparing the highest PFOA or PFHpS quartile to the lowest were 2.2 (95% CI: 1.2, 3.9) and 1.8 (95% CI: 1.0, 3.2). The ORs were also elevated for the second or third quartile of PFHxS or PFOS, but no consistent exposure-outcome pattern emerged. An interquartile range (IQR) increment in the WQS index of seven PFAS was associated with 64% higher odds for miscarriage (95% CI: 1.15, 2.34). The associations were stronger in parous women, while findings were inconsistent among nulliparous women. CONCLUSION: Maternal exposures to higher levels of PFOA, PFHpS, and PFAS mixtures were associated with the risk of miscarriage and particularly among parous women. Larger replication studies among nulliparous women are needed to allay concerns about confounding by reproductive history.

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Prenatal Exposure to Perfluoroalkyl Substances and Birth Outcomes; An Updated Analysis from the Danish National Birth Cohort

Cited by 100 publications

References 53 publications

Maternal serum concentrations of perfluoroalkyl substances and birth size in British boys

Maternal serum concentrations of perfluoroalkyl substances and birth size in British boys

Maternal serum levels of perfluoroalkyl substances in early pregnancy and offspring birth weight

Maternal Plasma Perfluoroalkyl Substances and Miscarriage: A Nested Case–Control Study in the Danish National Birth Cohort

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