Prenatal Exposure to Maternal Cigarette Smoking and the Adolescent Cerebral Cortex

Toro, Roberto; Leonard, Gabriel; Lerner, Jacqueline V.; Lerner, Richard M.; Perron, Michel; Pike, G. Bruce; Richer, Louis; Veillette, Suzanne; Pausová, Zdenka; Paus, Tomáš

doi:10.1038/sj.npp.1301484

Cited by 128 publications

(106 citation statements)

References 72 publications

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“…Importantly, alterations in these in brain regions have also been linked to deficits in cognitive abilities, auditory processing, social development, and ADHD. Results from the Saguenay Youth Study (Paus et al, 2008;Toro et al, 2008) revealed stronger effects in female offspring, highlighting the importance of examining gender differences in links between MSDP and offspring outcomes in future studies.…”

Section: Discussionmentioning

confidence: 99%

“…In general, the current body of literature is very small, and although each study involved unique analyses, several of the 11 studies involved analyses within overlapping participant samples (Jacobsen et al, 2006;Jacobsen, Picciotto et al, 2007;Jacobsen, Slotkin et al, 2007;Paus et al, 2008;Toro et al, 2008). Thus, integrated findings are based on only eight unique samples.…”

Section: Discussionmentioning

confidence: 99%

“…Regional brain measurements were assessed by MRI. Toro et al (2008) examined regional thickness of the cerebral cortex in a sample of 314 adolescents ages 12-18 years (155 exposed; findings also reported in Loftipour et al, 2009). They found thinning of a number of areas of the frontal, temporal, and parietal regions (including lateral orbitofrontal, middle frontal, and parahippocampal cortices-areas with high density of nicotinic receptors).…”

Section: Msdp Measurementioning

confidence: 99%

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Maternal Smoking During Pregnancy and Offspring Brain Structure and Function: Review and Agenda for Future Research

Bublitz

Stroud

2011

Nicotine & Tobacco Research

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Introduction: Maternal smoking during pregnancy (MSDP) has been associated with long-term neurobehavioral and cognitive deficits in offspring. Animal models demonstrate alterations in brain structure and function following prenatal nicotine exposure. However, few studies have assessed the relationship between MSDP and brain development in humans. Therefore, the aims of this review are (a) to synthesize findings from the small number of human studies investigating effects of MSDP on offspring brain development and (b) to outline an agenda for future research in this nascent area. Methods:We searched MEDLINE and Psychinfo databases for human studies of MSDP and offspring brain structure and/or function.Results: Eleven studies meeting our search criteria were identified; 6 studies investigated effects of MSDP on brain structure; 5 examined effects on brain function. Across studies, MSDP was associated with decreased volume/thickness of the cerebellum and corpus callosum, increased auditory brainstem responses, and lack of coordination across brain regions during information and auditory processing. Conclusions:Results from the small number of human studies revealed effects of MSDP on brain structure and function, highlighting potential neural pathways linking MSDP and offspring neurobehavioral and cognitive deficits. Given the limited amount of research in this area, we propose an agenda for future research. Gold standard studies would utilize longitudinal designs, integrated biological and maternal report measures of MSDP, and repeated measures of brain structure/function and neurobehavioral deficits across key developmental periods.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Msdp Measurementioning

confidence: 99%

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Maternal Smoking During Pregnancy and Offspring Brain Structure and Function: Review and Agenda for Future Research

Bublitz

Stroud

2011

Nicotine & Tobacco Research

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“…For example, prenatal tobacco exposure has been associated with reduction in cortical gray matter and parenchymal volumes in teenagers (Rivkin et al, 2008). Moreover, cortical thickness in the orbitofrontal, middle frontal, and parahippocampal gyrus have been reported to be thinner in adolescents exposed to prenatal tobacco (Toro et al, 2008;Lotfipour et al, 2009). This suggests that the region-specific effects of prenatal tobacco exposure may change over time.…”

Section: Discussionmentioning

confidence: 99%

“…Exposure to cigarette smoking has been associated with reduced cerebral cortical gray matter volume in children (Rivkin et al, 2008), and smaller subcortical gray matter volumes, including the amygdala, thalamus, and pallidum (Haghighi et al, 2013;Liu et al, 2013). In addition, prenatal tobacco-exposed adolescents have a reduced corpus callosum volume (Paus et al, 2008) and thinner orbitofrontal, middle frontal, and parahippocampal cortices (Toro et al, 2008;Lotfipour et al, 2009). However, a potential confounder is that these adolescents may have smoked themselves, as prenatally exposed children are more vulnerable to use tobacco themselves (Cornelius et al, 2000;Buka et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Prenatal Tobacco Exposure and Brain Morphology: A Prospective Study in Young Children

Marroun

Schmidt

Franken

et al. 2013

Neuropsychopharmacol

102

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It is well known that smoking during pregnancy can affect offspring health. Prenatal tobacco exposure has been associated with negative behavioral and cognitive outcomes in childhood, adolescence, and young adulthood. These associations between prenatal tobacco exposure and psychopathology in offspring could possibly be explained by the influence of prenatal tobacco exposure on brain development. In this prospective study, we investigated the association between prenatal tobacco exposure, behavioral and emotional functioning and brain morphology in young children. On the basis of age and gender, we matched 113 children prenatally exposed to tobacco with 113 unexposed controls. These children were part of a population-based study in the Netherlands, the Generation R Study, and were followed from pregnancy onward. Behavioral and emotional functioning was assessed at age 6 with the Child Behavior Checklist. We assessed brain morphology using magnetic resonance imaging techniques in children aged 6-8 years. Children exposed to tobacco throughout pregnancy have smaller total brain volumes and smaller cortical gray matter volumes. Continued prenatal tobacco exposure was associated with cortical thinning, primarily in the superior frontal, superior parietal, and precentral cortices. These children also demonstrated increased scores of affective problems. In addition, thickness of the precentral and superior frontal cortices was associated with affective problems. Importantly, brain development in offspring of mothers who quit smoking during pregnancy resembled that of nonexposed controls (no smaller brain volumes and no thinning of the cortex). Our findings suggest an association between continued prenatal tobacco exposure and brain structure and function in school-aged children.

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Orbitofrontal Cortex and Drug Use During Adolescence

Lotfipour¹,

Ferguson²,

Leonard³

et al. 2009

Arch Gen Psychiatry

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Prenatal Exposure to Maternal Cigarette Smoking and the Adolescent Cerebral Cortex

Cited by 128 publications

References 72 publications

Maternal Smoking During Pregnancy and Offspring Brain Structure and Function: Review and Agenda for Future Research

Maternal Smoking During Pregnancy and Offspring Brain Structure and Function: Review and Agenda for Future Research

Prenatal Tobacco Exposure and Brain Morphology: A Prospective Study in Young Children

Orbitofrontal Cortex and Drug Use During Adolescence

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