Prenatal exposure to low doses of atrazine affects mating behaviors in male guppies

Shenoy, K. Bhasker

doi:10.1016/j.yhbeh.2014.07.002

Cited by 13 publications

(33 citation statements)

References 106 publications

(115 reference statements)

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“…Exposure to endocrine and neuroendocrine disrupting chemicals (EDCs) are reported to induce a variety of aberrant behaviors (see reviews: [1,2]), particularly when individuals are exposed early in life [3][4][5][6][7][8]. EDCs interfere with the molecular mechanisms that underpin behavior, such as gene expression, hormone levels, neurotransmitter levels, and the molecular machinery that mediates between these inputs [9][10][11][12][13][14][15] predominantly implicated in the disruption of typical reproductive behaviors (i.e.…”

Section: Introductionmentioning

confidence: 99%

“…EDCs interfere with the molecular mechanisms that underpin behavior, such as gene expression, hormone levels, neurotransmitter levels, and the molecular machinery that mediates between these inputs [9][10][11][12][13][14][15] predominantly implicated in the disruption of typical reproductive behaviors (i.e. courtship and parental behavior; [2,3,16]), but non-reproductive behaviors, such as anxiety, aggression and risk-taking behavior also appear to be strongly affected [4,[17][18][19][20][21][22][22][23][24][25]). Increasingly, studies are revealing that the effects of EDCs may not be isolated to a single generation-offspring may indirectly be impacted through their parents via non-genetic processes (i.e.…”

Section: Introductionmentioning

confidence: 99%

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Paternal exposure to a common herbicide alters the behavior and serotonergic system of zebrafish offspring

2020

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Increasingly, studies are revealing that endocrine disrupting chemicals (EDCs) can alter animal behavior. Early life exposure to EDCs may permanently alter phenotypes through to adulthood. In addition, the effects of EDCs may not be isolated to a single generation − offspring may indirectly be impacted, via non-genetic processes. Here, we analyzed the effects of paternal atrazine exposure on behavioral traits (distance moved, exploration, bottomdwelling time, latency to enter the top zone, and interaction with a mirror) and whole-brain mRNA of genes involved in the serotonergic system regulation (slc6a4a, slc6a4b, htr1Aa, htr1B, htr2B) of zebrafish (Danio rerio). F0 male zebraFIsh were exposed to atrazine at 0.3, 3 or 30 part per billion (ppb) during early juvenile development, the behavior of F1 progeny was tested at adulthood, and the effect of 0.3 ppb atrazine treatment on mRNA transcription was quantified. Paternal exposure to atrazine significantly reduced interactions with a mirror (a proxy for aggression) and altered the latency to enter the top zone of a tank in unexposed F1 offspring. Bottom-dwelling time (a proxy for anxiety) also appeared to be somewhat affected, and activity (distance moved) was reduced in the context of aggression. slc6a4a and htr1Aa mRNA transcript levels were found to correlate positively with anxiety levels in controls, but we found that this relationship was disrupted in the 0.3 ppb atrazine treatment group. Overall, paternal atrazine exposure resulted in alterations across a variety of behavioral traits and showed signs of serotonergic system dysregulation, demonstrating intergenerational effects. Further research is needed to explore transgenerational effects on behavior and possible mechanisms underpinning behavioral effects. OPEN ACCESSCitation: Lamb SD, Chia JHZ, Johnson SL (2020) Paternal exposure to a common herbicide alters the behavior and serotonergic system of zebrafish offspring. PLoS ONE 15(4): e0228357. https://doi.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Paternal exposure to a common herbicide alters the behavior and serotonergic system of zebrafish offspring

2020

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“…A significant amount of studies has examined the effects of EDCs on reproductive behaviors in fish (for review see Söffker et al, 2012). Disturbed reproductive behavior has been observed in the three-spined stickleback, goldfish, guppy and zebrafish (Bayley et al, 1999;Bjerselius et al, 2001;EspmarkWibe et al, 2002a;Larsen et al, 2009;Shenoy, 2014). While the reproductive organs are able to recover from the effects of EDC exposure after remediation in clean water (Baumann et al, 2014;Larsen et al, 2009;Maack and Segner, 2004;Weber et al, 2003), the effects on fertilization success and reproductive behavior appear to be more persistent Larsen et al, 2009;Schäfers et al, 2007;Van den Belt et al, 2003).…”

Section: Introductionmentioning

confidence: 99%

Developmental exposure of zebrafish (Danio rerio) to 17α-ethinylestradiol affects non-reproductive behavior and fertility as adults, and increases anxiety in unexposed progeny

Volkova

Caspillo

Porseryd

et al. 2015

Hormones and Behavior

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Exposure to estrogenic endocrine disruptors (EDCs) during development affects fertility, reproductive and non-reproductive behavior in mammals and fish. These effects can also be transferred to coming generations. In fish, the effects of developmental EDC exposure on non-reproductive behavior are less well studied. Here, we analyze the effects of 17α-ethinylestradiol (EE2) on anxiety, shoaling behavior and fertility in zebrafish after developmental treatment and remediation in clean water until adulthood. Zebrafish embryos were exposed from day 1 to day 80 post fertilization to actual concentrations of 1.2 and 1.6ng/L EE2. After remediation for 82days non-reproductive behavior and fertilization success were analyzed in both sexes. Males and females from the 1.2ng/L group, as well as control males and females, were bred, and behavior of the untreated F1 offspring was tested as adults. Developmental treatment with 1.2 and 1.6ng/L EE2 significantly increased anxiety in the novel tank test and increased shoaling intensity in both sexes. Fertilization success was significantly reduced by EE2 in both sexes when mated with untreated fish of opposite sex. Progeny of fish treated with 1.2ng/L EE2 showed increased anxiety in the novel tank test and increased light avoidance in the scototaxis test compared to control offspring. In conclusion, developmental exposure of zebrafish to low doses of EE2 resulted in persistent changes in behavior and fertility. The behavior of unexposed progeny was affected by their parents' exposure, which might suggest transgenerational effects.

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“…Although direct breeding behavior was not assessed in these studies, previous studies note alterations in reproductive behavior in various fish species [121,122,129]. Furthermore, histological alterations within gonad tissue can also contribute to the lack of spawning events.…”

Section: The Effects Of Atrazine On Reproductive Function In Anuramentioning

confidence: 98%

Atrazine Exposure and Reproductive Dysfunction through the Hypothalamus-Pituitary-Gonadal (HPG) Axis

Wirbisky

Freeman

2015

Toxics

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Endocrine disrupting chemicals (EDC) are exogenous agents that alter endogenous hormone signaling pathways. These chemicals target the neuroendocrine system which is composed of organs throughout the body that work alongside the central nervous system to regulate biological processes. Of primary importance is the hypothalamic-pituitary-gonadal (HPG) axis which is vital for maintaining proper reproductive function. Atrazine (2-chloro-4-ethylamino-6-isopropylamino-1,3,5-triazine) is a pre-emergent herbicide used to prevent the growth of weeds on various crops. This herbicide is reported to widely contaminate potable water supplies everywhere it is applied. As such, the European Union banned the use of atrazine in 2004. Currently the United States Environmental Protection Agency regulates atrazine at 3 parts per billion (ppb; μg/L) in drinking water, while the World Health Organization recently changed their drinking water guideline to 100 ppb. Atrazine is implicated to be an EDC that alters reproductive dysfunction by targeting the HPG axis. However, questions remain as to the human health risks associated with atrazine exposure with studies reporting mixed results on the ability of atrazine to alter the HPG axis. In this review, the current findings for atrazine’s effects on the HPG axis are examined in mammalian, anuran, and fish models and in epidemiological studies.

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Prenatal exposure to low doses of atrazine affects mating behaviors in male guppies

Cited by 13 publications

References 106 publications

Paternal exposure to a common herbicide alters the behavior and serotonergic system of zebrafish offspring

Paternal exposure to a common herbicide alters the behavior and serotonergic system of zebrafish offspring

Developmental exposure of zebrafish (Danio rerio) to 17α-ethinylestradiol affects non-reproductive behavior and fertility as adults, and increases anxiety in unexposed progeny

Atrazine Exposure and Reproductive Dysfunction through the Hypothalamus-Pituitary-Gonadal (HPG) Axis

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