Prenatal exposure to exogenous progesterone adversely affects fetal development in Albino rats

Abstract

Background The current study was carried out to investigate the effects of exogenous progesterone on fetal development in rats. Results Placental weights did not vary in control and treated groups. Fetal weights were significantly reduced in the low- and high-dose progesterone groups. Fetal CVL was significantly reduced in both treatment groups compared to control group. In fetuses that received maternal treatment with low- and high-dose progesterone, several parts of the fetal skeleton showed incomplete ossification. Alkaline phosphatase was decreased in the bones of fetuses born to progesterone-treated dams. The testes and ovaries of the fetuses of the dams treated with low and high doses of progesterone showed degenerative seminiferous tubules and failed sex cord development into primordial follicles, respectively. Conclusions The administration of exogenous progesterone during pregnancy adversely influences fetal growth, skeletal construction, and sex organ development.