Prenatal exposure to endocrine disrupting chemicals is associated with altered DNA methylation in cord blood

Mattonet, Katharina; Nowack-Weyers, Nikola; Vogel, Vanessa; Moser, Dirk; Tierling, Sascha; Kasper-Sonnenberg, Monika; Wilhelm, Michael; Scherer, Michael; Walter, Jörn; Hengstler, Jan G.; Schölmerich, Axel; Kumsta, Robert

doi:10.1080/15592294.2021.1975917

Cited by 8 publications

(1 citation statement)

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“…Another recent historical cohort study showed that the paternal grandfather's nutrition leads to a transgenerational increase in cancer mortality rates in grandsons [112]. In line with that, prenatal exposure to pesticides and other endocrines disruptors linked to intergenerational development of cancer have been shown to alter epigenetic marks, particularly DNA methylation, in the progeny [75,113]. A few studies have also demonstrated that environmental insults result in molecular changes in the human germline.…”

Section: Pesticides Endocrine Disruptors and Epigenetic Changes In Th...mentioning

confidence: 86%

Epigenetic Inheritance: Intergenerational Effects of Pesticides and Other Endocrine Disruptors on Cancer Development

Nicolella

Assis

2022

IJMS

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Parental environmental experiences affect disease susceptibility in the progeny through epigenetic inheritance. Pesticides are substances or mixtures of chemicals—some of which are persistent environmental pollutants—that are used to control pests. This review explores the evidence linking parental exposure to pesticides and endocrine disruptors to intergenerational and transgenerational susceptibility of cancer in population studies and animal models. We also discuss the impact of pesticides and other endocrine disruptors on the germline epigenome as well as the emerging evidence for how epigenetic information is transmitted between generations. Finally, we discuss the importance of this mode of inheritance in the context of cancer prevention and the challenges ahead.

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Section: Pesticides Endocrine Disruptors and Epigenetic Changes In Th...mentioning

confidence: 86%