Prenatal Exposure to BPA: The Effects on Hepatic Lipid Metabolism in Male and Female Rat Fetuses

Tonini, Claudia; Segatto, Marco; Bertoli, Simona; Mazzoli, Arianna; Cigliano, Luisa; Barberio, Laura; Mandalà, Maurizio; Pallottini, Valentina

doi:10.3390/nu13061970

Cited by 19 publications

(13 citation statements)

References 65 publications

(89 reference statements)

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“…This lipid accumulation was associated with hyperinsulinemia and the disruption of genes involved in hepatic lipogenesis and cholesterogenesis [61]. These effects on hepatic lipid metabolism were confirmed by many studies that followed, whether they studied exposures in adults or in perinatal mice [59,60,63,64].…”

Section: Effect Of Bpa On the Livermentioning

confidence: 79%

Are BPA Substitutes as Obesogenic as BPA?

Oliviero

Marmugi

Viguié

et al. 2022

IJMS

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Metabolic diseases, such as obesity, Type II diabetes and hepatic steatosis, are a significant public health concern affecting more than half a billion people worldwide. The prevalence of these diseases is constantly increasing in developed countries, affecting all age groups. The pathogenesis of metabolic diseases is complex and multifactorial. Inducer factors can either be genetic or linked to a sedentary lifestyle and/or consumption of high-fat and sugar diets. In 2002, a new concept of “environmental obesogens” emerged, suggesting that environmental chemicals could play an active role in the etiology of obesity. Bisphenol A (BPA), a xenoestrogen widely used in the plastic food packaging industry has been shown to affect many physiological functions and has been linked to reproductive, endocrine and metabolic disorders and cancer. Therefore, the widespread use of BPA during the last 30 years could have contributed to the increased incidence of metabolic diseases. BPA was banned in baby bottles in Canada in 2008 and in all food-oriented packaging in France from 1 January 2015. Since the BPA ban, substitutes with a similar structure and properties have been used by industrials even though their toxic potential is unknown. Bisphenol S has mainly replaced BPA in consumer products as reflected by the almost ubiquitous human exposure to this contaminant. This review focuses on the metabolic effects and targets of BPA and recent data, which suggest comparable effects of the structural analogs used as substitutes.

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Section: Effect Of Bpa On the Livermentioning

confidence: 79%

Are BPA Substitutes as Obesogenic as BPA?

Oliviero

Marmugi

Viguié

et al. 2022

IJMS

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“…Noteworthily, the urinary concentrations of BPA and phthalate metabolites in our study were far below the reference HBM values for the general population estimated by biomonitoring data. However, some recent studies in rat fetuses [69,70] have shown that maternal exposure to very low doses of BPA (2.5 µg/kg/day) was able to alter hepatic lipid metabolism and metabolic pathways important for the proper development and functioning of the brain. Furthermore, other studies [71,72] have shown that gestational exposure to BPA at low doses was able to cause cognitive deficits and influence the development of circadian centers in the offspring of rats and mice.…”

Section: Discussionmentioning

confidence: 99%

Lifestyle Habits and Exposure to BPA and Phthalates in Women of Childbearing Age from Northern Italy: A Pilot Study

Napoli

Tagliaferri

Sommella

et al. 2021

IJERPH

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Background: Endocrine-disrupting chemicals (EDCs) are compounds that interfere with aspects of hormonal signaling. Considerable attention has been paid to their biological effects especially in women of childbearing age or during pregnancy as EDCs have been reported to cross the placenta becoming concentrated in the fetus’ circulation. Lifestyle habits, daily consumption of packaged foods and use of healthcare/cosmetic products are associated with increased EDCs levels. This cross-sectional research examined the EDCs levels and the lifestyle determinants of EDC exposure in a cohort of reproductive-age women from Northern Italy. Methods: Forty-five women (median age: 36, IQR: 30–38) were evaluated for urinary bisphenol A (BPA) and phthalates levels and also studied for EDCs’ major determinants of daily exposure; food frequency/dietary, physical activity, smoking habits and weight status. Results: Although 100% of women seemed to have been exposed to common sources of EDCs, they reported a healthy lifestyle. The multivariable model described a positive and significant association between consumption of sauces/dressings in plastic containers and monoethyl phthalate exposure (p = 0.037). Conclusions: Since reproductive age encompasses a critical window for future health and functioning of the “mothers-to-be” and their children, future studies on prenatal dietary BPA and phthalate exposure and the role of consumer product choices in reducing such exposure are recommended.

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“…A recent study conducted by Tonini et al to examine the impact of prenatal exposure to low-dose BPA (2.5 µg/kg/day) on the livers of SD rat foetuses showed that BPA had no effect on TG or total, LDL, or HDL cholesterol in the serum samples of mother rats, and there was no effect on hepatic TG or total cholesterol content in foetal rats [51]. In contrast, C57BL/6J mice exposed to a low dose of BPA (5 µg/kg/day) showed that low gestational BPA exposure significantly increased BW at 13, 14, 20, and 22 weeks and caused a significant decrease in hepatic TG content.…”

Section: High and Low Doses Of Developmental Bpa Exposure And Lipid P...mentioning

confidence: 99%

The Current Findings on the Impact of Prenatal BPA Exposure on Metabolic Parameters: In Vivo and Epidemiological Evidence

2022

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Metabolic syndrome (MS) is a multifactorial disease entity and is not fully understood. Growing evidence suggests that early exposure to bisphenol A (BPA) is a significant risk factor for the development of metabolic diseases. BPA is a monomer used in the manufacturing of polycarbonate plastics, thermal receipt paper, and epoxy resins. Owing to its widespread use, BPA has been detected in human fluids and tissues, including blood, placental breast milk, and follicular fluid. In the present review, we aimed to review the impact of prenatal exposure to different doses of BPA on metabolic parameters as determined by in vivo and epidemiological studies. The PubMed, Scopus, and Web of Science electronic databases were searched to identify articles published during a period of 15 years from 2006 to 2021, and 29 studies met the criteria. Most studies demonstrated that prenatal exposure to low BPA concentrations correlated with alterations in metabolic parameters in childhood and an increased risk of metabolic diseases, such as obesity and type 2 diabetes mellitus (T2DM), in adulthood. Therefore, prenatal exposure to low doses of BPA may be associated with an increased risk of obesity and T2DM in a sex-specific manner.

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Prenatal Exposure to BPA: The Effects on Hepatic Lipid Metabolism in Male and Female Rat Fetuses

Cited by 19 publications

References 65 publications

Are BPA Substitutes as Obesogenic as BPA?

Are BPA Substitutes as Obesogenic as BPA?

Lifestyle Habits and Exposure to BPA and Phthalates in Women of Childbearing Age from Northern Italy: A Pilot Study

The Current Findings on the Impact of Prenatal BPA Exposure on Metabolic Parameters: In Vivo and Epidemiological Evidence

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