Prenatal exposure to bisphenol A and risk of allergic diseases in early life

Zhou, Aifen; Chang, Huailong; Huo, Wenqian; Zhang, Bin; Hu, Jie; Xia, Wei; Chen, Zhong; Xiong, Chao; Zhang, Yaqi; Wang, Youjie; Xu, Shunqing; Li, Yuanyuan

doi:10.1038/pr.2017.20

Cited by 53 publications

(28 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…Along with the fundamental complexity of the inflammatory response to differing concentrations of these estrogen-like compounds being layered upon fluctuating levels of circulating and local hormone levels, predicting the effects of exogenous estrogens is complicated further because each compound has unique, and most often poorly understood impacts on endogenous estrogen responses due to their varying ability to act as estrogen mimics, partial agonists, and/or antagonists and their activity at different receptor systems. The findings of this study support and extend previous findings in experimental animals, and an increasing body of humans studies that suggest links between BPA exposures and varied impacts on immune responsiveness, autoimmunity, and allergic diseases [14][15][16][17][18][19][20][54][55][56][57][58] .…”

Section: Discussionsupporting

confidence: 88%

Impacts of Bisphenol A and Ethinyl Estradiol on Male and Female CD-1 Mouse Spleen

Gear

Belcher

2017

Preprint

View full text Add to dashboard Cite

The endocrine disruptor bisphenol A (BPA) and the pharmaceutical 17α-ethinyl estradiol (EE) are synthetic chemicals with estrogen-like activities. Despite ubiquitous human exposure to BPA, and the wide-spread clinical use of EE as oral contraceptive adjuvant, the impact of these estrogenic endocrine disrupting chemicals (EDCs) on the immune system is unclear. Here we report results of in vivo dose response studies that analyzed the histology and microstructural changes in the spleen of adult male and female CD-1 mice exposed to 4 to 40,000 μg/kg/day BPA or 0.02 to 2 μg/kg/day EE from conception until 12-14 weeks of age. Results of that analysis indicate that both BPA and EE have dose-and sex-specific impacts on the cellular and microanatomical structures of the spleens that reveal minor alterations in immunomodulatory and hematopoietic functions. These findings support previous studies demonstrating the murine immune system as a sensitive target for estrogens, and that oral exposures to BPA and EE can have estrogen-like immunomodulatory affects in both sexes.

show abstract

Section: Discussionsupporting

confidence: 88%

Impacts of Bisphenol A and Ethinyl Estradiol on Male and Female CD-1 Mouse Spleen

Gear

Belcher

2017

Preprint

View full text Add to dashboard Cite

show abstract

“…Mouse models suggest that BPA exacerbates allergic inflammation [37][38][39][40] and that maternal exposure to BPA enhances the development of allergic inflammation in offspring [15]. There are multiple epidemiological studies linking bisphenol exposures (typically measured in urine) to the development of asthma and other allergic conditions [41][42][43]. For example, higher postnatal urinary BPA concentrations were associated significantly with asthma in inner-city children [16].…”

Section: Discussionmentioning

confidence: 99%

Endocrine Disruptor Bisphenol A (BPA) Triggers Systemic Para-Inflammation and is Sufficient to Induce Airway Allergic Sensitization in Mice

2020

View full text Add to dashboard Cite

Allergic airway diseases are accompanied by increased permeability and an inflammatory state of epithelial barriers, which are thought to be susceptible to allergen sensitization. Although exogenous drivers (proteases, allergens) of epithelial barrier disruption and sensitization are well studied, endogenous contributors (diet, xenobiotics, hormones, and metabolism) to allergic sensitization are much less understood. Xenoestrogens are synthetic or natural chemical compounds that have the ability to mimic estrogen and are ubiquitous in the food and water supply of developed countries. By interfering with the estrogen produced by the endocrine system, these compounds have the systemic potential to disrupt the homeostasis of multiple tissues. Our study examined the potential of prototypical xenoestrogen bisphenol A (BPA) to disrupt epithelial homeostasis in vitro and promote allergic responses in vivo. We found that BPA exposure in epithelial cultures in vitro significantly inhibited epithelial cell proliferation and wound healing, as well as promoted the expression of the innate alarmin cytokine TSLP in a time-and dose-dependent manner. In vivo, the exposure to BPA through water supply or inhalation induced a systemic para-inflammatory response by promoting the expression of innate inflammatory mediators in the skin, gut, and airway. In a murine tolerogenic antigen challenge model, chronic systemic exposure to BPA was sufficient to induce airway sensitization to innocuous chicken egg ovalbumin in the complete absence of adjuvants. Mechanistic studies are needed to test conclusively whether endocrine disruptors may play an upstream role in allergic sensitization via their ability to promote a para-inflammatory state.

show abstract

“…It is able to cross the placenta and is present in the umbilical cord blood, amniotic fluid, as well as in the breast milk in women (Gerona et al, 2013;Reddivari et al, 2017). Although the contribution of bisphenol A on the appearance of IUGR in humans remains controversial (Hu et al, 2018), studies have found that concentrations of bisphenol A in women during pregnancy correlate positively with the development of asthma, respiratory tract infections, and allergies in their child (Gascon et al, 2015;Zhou et al, 2017). In rabbits, intrauterine exposure to bisphenol A did not affect birth weight, litter size, and survival or sex ratio (Reddivari et al, 2017).…”

Section: Endocrine Disruptorsmentioning

confidence: 99%

Models of Intrauterine growth restriction and fetal programming in rabbits

López-Tello

Álvarez

González-Bulnes³

et al. 2019

Molecular Reproduction Devel

View full text Add to dashboard Cite

Intrauterine growth restriction (IUGR) affects approximately 10% of human pregnancies globally and has immediate and life‐long consequences for offspring health. However, the mechanisms underlying the pathogenesis of IUGR and its association with later health and disease outcomes are poorly understood. To address these knowledge gaps, the use of experimental animals is critically important. Since the 50's different environmental, pharmacological, and surgical manipulations have been performed in the rabbit to improve our knowledge of the control of fetal growth, fetal responses to IUGR, and mechanisms by which offspring may be programmed by an adverse gestational environment. The purpose of this review is therefore to summarize the utility of the rabbit as a model for IUGR research. It first summarizes the knowledge of prenatal and postnatal development in the rabbit and how these events relate to developmental milestones in humans. It then describes the methods used to induce IUGR in rabbits and the knowledge gained about the mechanisms determining prenatal and postnatal outcomes of the offspring. Finally, it discusses the application of state of the art approaches in the rabbit, including high‐resolution ultrasound, magnetic resonance imaging, and gene targeting, to gain a deeper integrative understanding of the physiological and molecular events governing the development of IUGR. Overall, we hope to engage and inspire investigators to employ the rabbit as a model organism when studying pregnancy physiology so that we may advance our understanding of mechanisms underlying IUGR and its consequences in humans and other mammalian species.

show abstract

Prenatal exposure to bisphenol A and risk of allergic diseases in early life

Abstract: Prenatal exposure to BPA may potentially increase the risk of allergic diseases at very early life in female infants.

Cited by 53 publications

References 32 publications

Impacts of Bisphenol A and Ethinyl Estradiol on Male and Female CD-1 Mouse Spleen

Impacts of Bisphenol A and Ethinyl Estradiol on Male and Female CD-1 Mouse Spleen

Endocrine Disruptor Bisphenol A (BPA) Triggers Systemic Para-Inflammation and is Sufficient to Induce Airway Allergic Sensitization in Mice

Models of Intrauterine growth restriction and fetal programming in rabbits

Contact Info

Product

Resources

About