Prenatal Exposure to Arsenic and Its Effects on Fetal Development in the General Population of Dalian

Guan, Huai; Piao, Fengyuan; Zhang, Xuan; Li, Xiaowei; Li, Qiujuan; Xu, Lei; Kitamura, Fumihiko; Yokoyama, Kazuhito

doi:10.1007/s12011-012-9396-7

Cited by 47 publications

(42 citation statements)

References 16 publications

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“…72 Similarly, in a study on the general population in Dalian, China, infants born to mothers with arsenic blood levels greater than 5.3 μg/L weighed 220 g less than those infants whose mothers had lower blood arsenic levels. 73 This study also demonstrated a significant, strong correlation between maternal arsenic and cord blood arsenic. These studies indicate that low levels of arsenic can have direct impacts on the growth of newborns.…”

Section: ■ Discussionsupporting

confidence: 61%

Arsenic and Its Methylated Metabolites Inhibit the Differentiation of Neural Plate Border Specifier Cells

McCoy

Stadelman

Brumaghim

et al. 2015

Chem. Res. Toxicol.

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Exposure to arsenic in food and drinking water has been correlated with adverse developmental outcomes, such as reductions in birth weight and neurological deficits. Additionally, studies have shown that arsenic suppresses sensory neuron formation and skeletal muscle myogenesis, although the reason why arsenic targets both of these cell types in unclear. Thus, P19 mouse embryonic stem cells were used to investigate the mechanisms by which arsenic could inhibit cellular differentiation. P19 cells were exposed to 0, 0.1, or 0.5 μM sodium arsenite and induced to form embryoid bodies over a period of 5 days. The expression of transcription factors necessary to form neural plate border specifier (NPBS) cells, neural crest cells and their progenitors, and myocytes and their progenitors were examined. Early during differentiation, arsenic significantly reduced the transcript and protein expression of Msx1 and Pax3, both needed for NPBS cell formation. Arsenic also significantly reduced the protein expression of Sox 10, needed for neural crest progenitor cell production, by 31-50%, and downregulated the protein and mRNA levels of NeuroD1, needed for neural crest cell differentiation, in a time- and dose-dependent manner. While the overall protein expression of transcription factors in the skeletal muscle lineage was not changed, arsenic did alter their nuclear localization. MyoD nuclear translocation was significantly reduced on days 2-5 between 15 and 70%. At a 10-fold lower concentration, monomethylarsonous acid (MMA III) appeared to be just as potent as inorganic arsenic at reducing the mRNA levels Pax3 (79% vs84%), Sox10 (49% vs 65%), and Msx1 (56% vs 56%). Dimethylarsinous acid (DMA III) also reduced protein and transcript expression, but the changes were less dramatic than those with MMA or arsenite. All three arsenic species reduced the nuclear localization of MyoD and NeuroD1 in a similar manner. The early changes in the differentiation of neural plate border specifier cells may provide a mechanism for arsenic to suppress both neurogenesis and myogenesis.

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Section: ■ Discussionsupporting

confidence: 61%

Arsenic and Its Methylated Metabolites Inhibit the Differentiation of Neural Plate Border Specifier Cells

McCoy

Stadelman

Brumaghim

et al. 2015

Chem. Res. Toxicol.

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“…Yet, no associations were detected for 71 female newborns. In another study, 125 women were recruited from a primary delivery center in Dalian City (Guan et al, 2012). Total arsenic was measured in maternal blood collected upon admission for delivery (median = 5.30 μg/L, range = 0- ~25) and umbilical cord blood collected prior to passage of the placenta (median = 3.71 μg/L, range = 0- ~25).…”

Section: Resultsmentioning

confidence: 99%

“…Though the authors of these cross-sectional studies employed hospital delivery records and biomarkers of exposure, the use of total blood arsenic raises concern (Guan et al, 2012; Xu et al, 2011). Total blood arsenic incorporates both iAs as well as the comparatively non-toxic organic arsenic species (Akter et al, 2006) to which humans are exposed when consuming seafood (Le et al, 1994; Navas-Acien et al, 2011).…”

Section: Resultsmentioning

confidence: 99%

Maternal arsenic exposure and birth outcomes: A comprehensive review of the epidemiologic literature focused on drinking water

Bloom

Surdu

Neamtiu³

et al. 2014

International Journal of Hygiene and Environmental Health

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Inorganic arsenic (iAs) is a human toxicant to which populations may be exposed through consumption of geogenically contaminated groundwater. A growing body of experimental literature corroborates the reproductive toxicity of iAs; however, the results of human studies are inconsistent. Therefore, we conducted a comprehensive review of epidemiologic studies focused on drinking water iAs exposure and birth outcomes to assess the evidence for causality and to make recommendations for future study. We reviewed 18 English language papers assessing birth weight, gestational age, and birth size. Thirteen of the studies were conducted among populations with frequent exposure to high-level groundwater iAs contamination (>10 μg/L) and five studies were conducted in areas without recognized contamination. Most studies comprised small samples and used cross-sectional designs, often with ecologic exposure assessment strategies, although several large prospective investigations and studies with individual-level measurements were also reported. We conclude that: 1) the epidemiologic evidence for an increased risk of low birth weight (<2,500 grams) is insufficient, although there exists limited evidence for birth weight decreases; 2) the evidence for increased preterm delivery is insufficient; and, 3) there exists minimal evidence for decreased birth size. In further investigation of birth weight and size, we recommend incorporation of individual susceptibility measures using appropriate biomarkers, with collection timed to windows of vulnerability and speciated arsenic analysis, as well as consideration of populations exposed primarily to drinking water iAs contamination <10 μg/L. Given the large potential public health impact, additional, high quality epidemiologic studies are necessary to more definitively assess the risk.

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“…1 Data from exposure assessment studies demonstrate that arsenic readily crosses the placenta and that fetal exposure is highly correlated with maternal exposure. [2][3][4][5] Evidence from epidemiological studies shows that early life exposure to arsenic is associated with increased risk of adverse health outcomes later in life. For instance, a large ecological study in Chile reported that people in Antofagasta who were exposed to high concentrations of arsenic either prenatally or in early childhood had significantly higher mortality from lung cancer and bronchiectasis compared with people from other parts of the country.…”

Section: Introductionmentioning

confidence: 99%

Effect of prenatal arsenic exposure on DNA methylation and leukocyte subpopulations in cord blood

et al. 2014

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Prenatal Exposure to Arsenic and Its Effects on Fetal Development in the General Population of Dalian

Cited by 47 publications

References 16 publications

Arsenic and Its Methylated Metabolites Inhibit the Differentiation of Neural Plate Border Specifier Cells

Arsenic and Its Methylated Metabolites Inhibit the Differentiation of Neural Plate Border Specifier Cells

Maternal arsenic exposure and birth outcomes: A comprehensive review of the epidemiologic literature focused on drinking water

Effect of prenatal arsenic exposure on DNA methylation and leukocyte subpopulations in cord blood

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