Prenatal exposure to a mixture of organochlorines and metals and internalizing symptoms in childhood and adolescence

Rokoff, Lisa B.; Shoaff, Jessica R.; Coull, Brent A.; Enlow, Michelle Bosquet; Bellinger, David C.; Korrick, Susan A.

doi:10.1016/j.envres.2022.112701

Cited by 14 publications

(24 citation statements)

References 83 publications

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“…Although most prior literature, including in the NBC, has reported no associations between prenatal organochlorine levels and subsequent internalizing symptoms, 15 – 21 we found evidence of prenatal HCB and

′-DDE as risk factors for elevated internalizing symptoms in early adulthood, in most cases with stronger associations in certain levels of the sociodemographic or nonchemical stressors. The adverse associations of prenatal HCB and

′-DDE levels and risk of elevated anxiety symptoms was stronger for young adult participants who identified as underrepresented racial/ethnic group participants.…”

Section: Discussioncontrasting

confidence: 79%

“…Consistent with associations of prenatal Pb and self-report anxiety symptoms in adolescence in the NBC, 15 higher prenatal Pb levels were associated with increased risk of elevated anxiety symptoms in early adulthood. Prior studies of prenatal Pb exposure and internalizing symptoms have mainly assessed outcomes in early or mid-childhood, 16 , 21 – 24 prior to core risk periods for the onset of anxiety and depressive disorders, 3 , 26 and largely have not observed associations.…”

Section: Discussionsupporting

confidence: 58%

“…Child participants have undergone periodic follow-up assessments from birth through early adulthood. 15 , 32 – 35 …”

Section: Methodsmentioning

confidence: 99%

“…In cases where data on one of these covariates were missing in our analytic cohort (

; 1%), we weighted the composite score to five responses and rounded to the nearest whole number (i.e., multiplied by five-fourths); if

covariate was missing data, then the prenatal social disadvantage index (PNSDI) score was considered missing. For analyses, we derived a dichotomized variable in which

was considered high disadvantage, 15 , 40 , 49 , 50 because this cut point was sensitive to greater risk of exposure to other prenatal and childhood environmental and social stressors in the NBC.…”

Section: Methodsmentioning

confidence: 99%

“…Previous studies of internalizing symptoms in childhood, including our prior work in the New Bedford Cohort (NBC), 15 have provided limited evidence of associations (i.e., largely null results) with prenatal exposure to organochlorines, including hexachlorobenzene (HCB), 16 – 19 dichlorodiphenyldichloroethylene (

′-DDE), 16 – 20 and polychlorinated biphenyls (PCBs), 16 – 21 and mixed evidence of associations (i.e., positive and null results) with prenatal exposure to lead (Pb) 16 , 21 – 24 and manganese (Mn). 24 , 25 In the NBC, we found an adverse association between prenatal Pb and self-reported anxiety-related symptoms in adolescence but not with parent-reported symptoms in mid-childhood, 15 highlighting that neurobehavioral effects related to early chemical exposures may not be apparent until later in development, during or after core risk periods for onset of internalizing disorders, 3 , 26 and when more accurate self-report of symptoms 27 , 28 can be ascertained. Additionally, most of this literature did not explore whether coexposures to other risk factors for neurobehavioral disorders (e.g., sociodemographic, nonchemical, and other chemical stressors) modify associations.…”

Section: Introductionmentioning

confidence: 99%

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Associations of Prenatal Chemical and Nonchemical Stressors with Early-Adulthood Anxiety and Depressive Symptoms

Rokoff

Coull

Enlow

et al. 2023

Environ Health Perspect

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Background: Prenatal exposure to environmental chemicals may increase risk of childhood internalizing problems, but few studies have explored the potential for longer-term consequences of such exposures. Objective: We evaluated associations between prenatal organochlorine and metal levels and early adulthood internalizing symptoms, considering whether sociodemographic/nonchemical stressors modified these associations. Methods: Participants were 209 young adults, born (1993–1998) to mothers residing in or near New Bedford, Massachusetts. As part of the early-adult assessment, self-reported anxiety (7-item Generalized Anxiety Disorder scale) and depressive (8-item Patient Health Questionnaire) symptoms ( : elevated symptoms) were ascertained. We previously analyzed levels of cord serum organochlorines [hexachlorobenzene, dichlorodiphenyldichloroethylene ( , ′-DDE), polychlorinated biphenyls ( : sum of congeners 118, 138, 153, 180)] and whole blood lead shortly after participants’ birth, and levels of cord whole blood manganese from archived samples at the time of the adolescent study visit. We used modified Poisson regression models and quantile g-computation, adjusting for sociodemographics, and explored whether biological sex, race/ethnicity (proxy for unmeasured consequences of racism), prenatal social disadvantage (assessed when participants were neonates), and quality of the home environment (assessed during adolescence) modified these associations. Results: Participants were ( ) y old, 76% Non-Hispanic White, and 67% female. Prenatal hexachlorobenzene, , ′-DDE, and lead exposures were moderately associated with increased risk of elevated anxiety symptoms. There were strata-specific associations for prenatal social disadvantage and quality of home environment such that adverse associations of , ′-DDE and lead and the overall mixture with anxiety and depressive symptoms were largely only evident in those with lower nonchemical stress [e.g., risk ratio and 95% confidence interval (CI) per doubling , ′-DDE for anxiety: 1.54 (95% CI: 1.20, 1.99) in high-quality home environments and 0.77 (95% CI: 0.51, 1.16) in low-quality home environments]. Associations between prenatal hexachlorobenzene and , ′-DDE and anxiety symptoms were stronger for underrepresented racial/ethnic group participants vs. Non-Hispanic Whites. We found minimal evidence for sex-specific effects, and no consistent associations with manganese or . Discussion: Prenatal organochlorine pesticides and lead exposure possibly increases risk of internalizing problems, particular anxiety symptoms, in young adults. Varying risk was observed by sociodemographic/nonchemical stressor strata, d...

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′-DDE levels and risk of elevated anxiety symptoms was stronger for young adult participants who identified as underrepresented racial/ethnic group participants.…”

Section: Discussioncontrasting

confidence: 79%

Section: Discussionsupporting

confidence: 58%

“…Child participants have undergone periodic follow-up assessments from birth through early adulthood. 15 , 32 – 35 …”

Section: Methodsmentioning

confidence: 99%

“…In cases where data on one of these covariates were missing in our analytic cohort (

; 1%), we weighted the composite score to five responses and rounded to the nearest whole number (i.e., multiplied by five-fourths); if

covariate was missing data, then the prenatal social disadvantage index (PNSDI) score was considered missing. For analyses, we derived a dichotomized variable in which

Section: Methodsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Associations of Prenatal Chemical and Nonchemical Stressors with Early-Adulthood Anxiety and Depressive Symptoms

Rokoff

Coull

Enlow

et al. 2023

Environ Health Perspect

Self Cite

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Prenatal Metals Exposure and pre-adolescents’ Emotional and Behavioral Problems

Lozano,

Broberg,

Soler-Blasco

et al. 2023

Expo Health

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Emotional and behavioral problems during childhood raise the risk of subsequent developmental of mental disorders. Our aim was to study the association between maternal metal and trace element concentrations during gestation and these problems in 9 year-old children. The study sample comprised Spanish mother-child pairs in the INMA project (n = 1003). Metals and trace elements (As, Cd, Co, Cu, Mo, Ni, Pb, Sb, Se, Tl and Zn) were measured in urine samples collected during pregnancy. Inorganic As metabolites were speciated in a subsample (n = 729). Emotional and behavioral problems were assessed using the Child Behavior Checklist (CBCL) composed of three scales: internalizing, externalizing and total problems. Sociodemographic, dietary and exposure to other environmental pollutants were obtained through questionnaires. Single nucleotide polymorphisms in brain- and metabolism-related genes APOE, BDNF, GSTP1, and PON1 were determined in cord blood. Multivariate negative binomial models were used. The interaction with sex and genotypes was evaluated including interaction terms. A multi-element analysis was carried out by a principal component analysis. Higher concentrations of Cu, monomethylarsonic acid, and Pb during pregnancy were associated with an increased incidence ratio risk (IRR) between 4.6 and 7.5% for internalizing and externalizing problems for all three CBCL scales in the children. Increasing Mo, Ni and Co concentrations were associated with higher IRR for internalizing problems (up to 8%), and Cd for externalizing problems (6.7%). Modifications by sex and genotypes were found for several associations. Multi-element analysis associated multiple metals and trace elements (Ni, Cu, Se, Cd and Pb) with higher internalizing problems.

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Associations of plasma manganese with adverse pregnancy outcomes: Nested case-control studies in a Chinese birth cohort

Zhang,

Chen,

Xia

et al. 2023

Chemosphere

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Prenatal exposure to a mixture of organochlorines and metals and internalizing symptoms in childhood and adolescence

Cited by 14 publications

References 83 publications

Associations of Prenatal Chemical and Nonchemical Stressors with Early-Adulthood Anxiety and Depressive Symptoms

Associations of Prenatal Chemical and Nonchemical Stressors with Early-Adulthood Anxiety and Depressive Symptoms

Prenatal Metals Exposure and pre-adolescents’ Emotional and Behavioral Problems

Associations of plasma manganese with adverse pregnancy outcomes: Nested case-control studies in a Chinese birth cohort

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