Prenatal exposure to a low fipronil dose disturbs maternal behavior and reflex development in rats

Udo, Mariana Sayuri Berto; Sandini, Thaísa Meira; Reis, Thiago M.; Bernardi, Maria Martha

doi:10.1016/j.ntt.2014.05.010

Cited by 40 publications

(27 citation statements)

References 31 publications

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“…In mammals, neurobehavioral effects included diminished learning ability (Kara et al 2015), enhanced social dominance and reduced aggression (Burke 2016), and disrupted spatial memory during echo-location in bats when exposed to imidacloprid (Hsiao et al 2016); deteriorated cognitive function in infants (Ozdemir et al 2014) and increased anxiety-like behavior (Hirano et al 2015) when exposed to clothianidin, and impaired memory following lactational exposure (Montanha et al 2016), disturbed maternal behaviors, such as aggression (Magalhaes et al 2015), and altered reflex development in offspring (Udo et al 2014) when exposed to fipronil. Exposure to imidacloprid also altered the regulation of genes important in mammalian brain development (Kimura-Kuroda et al 2016).…”

Section: Sublethal Effectsmentioning

confidence: 99%

An update of the Worldwide Integrated Assessment (WIA) on systemic insecticides. Part 2: impacts on organisms and ecosystems

Pisa

Goulson

Yang

et al. 2017

Environ Sci Pollut Res

189

144

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New information on the lethal and sublethal effects of neonicotinoids and fipronil on organisms is presented in this review, complementing the previous Worldwide Integrated Assessment (WIA) in 2015. The high toxicity of these systemic insecticides to invertebrates has been confirmed and expanded to include more species and compounds. Most of the recent research has focused on bees and the sublethal and ecological impacts these insecticides have on pollinators. Toxic effects on other invertebrate taxa also covered predatory and parasitoid natural enemies and aquatic arthropods. Little new information has been gathered on soil organisms. The impact on marine and coastal ecosystems is still largely uncharted. The chronic lethality of neonicotinoids to insects and crustaceans, and the strengthened evidence that these chemicals also impair the immune system and reproduction, highlights the dangers of this particular insecticidal class (neonicotinoids and fipronil), with the potential to greatly decrease populations of arthropods in both terrestrial and aquatic environments. Sublethal effects on fish, reptiles, frogs, birds, and mammals are also reported, showing a better understanding of the mechanisms of toxicity of these insecticides in vertebrates and their deleterious impacts on growth, reproduction, and neurobehaviour of most of the species tested. This review concludes with a summary of impacts on the ecosystem services and functioning, particularly on pollination, soil biota, and aquatic invertebrate communities, thus reinforcing the previous WIA conclusions .

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Section: Sublethal Effectsmentioning

confidence: 99%

An update of the Worldwide Integrated Assessment (WIA) on systemic insecticides. Part 2: impacts on organisms and ecosystems

Pisa

Goulson

Yang

et al. 2017

Environ Sci Pollut Res

189

144

View full text Add to dashboard Cite

show abstract

“…Nevertheless, few neurobehavioral toxicity studies of ethiprole were carried out excluding the above report. Nevertheless, Udo et al () reported that fipronil, which is similar in toxicity, chemical structure and mode of action to ethiprole (Sparks, ; Arthur, ), disturbed maternal behavior and reflex development of offspring in rats. Therefore, the present study was designed to evaluate the reproductive and neurobehavioral effects of ethiprole exposure in mice throughout different generations.…”

Section: Introductionmentioning

confidence: 99%

Reproductive and Neurobehavioral Effects of Ethiprole Administered to Mice in the Diet

Tanaka

Inomata

2017

Birth Defects Research

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“…This delay in most parameters of physical development in both male and female mice may have occurred owing to a reduction in maternal behavior, and due to the effect of dipyrone itself on the offspring. In addition, neonatal reflexes may be considered as an index of brain maturation (Udo et al, 2014), and offspring from dipyrone group showed a delay in many of the reflexes assessed in both male and female mice. Thus, our results suggest that a reduction in maternal behavior together with dipyrone during lactation affected neural mechanisms responsible for proper brain maturation.…”

Section: Discussionmentioning

confidence: 99%

Maternal dipyrone treatment during lactation in mice reduces maternal behavior and increases anxiety‐like behavior in offspring

Veronesi

Batista

Ribeiro

et al. 2017

Intl J of Devlp Neuroscience

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Dipyrone (metamizole), a powerful drug, is widely used as an analgesic and antipyretic; however, the safety of its use during lactation and the potential impact on the offspring are not well established. This study aimed to determine the effect of maternal dipyrone treatment during lactation on offspring development and emotional behavior and on the dam's maternal behavior. Hence, on postnatal day (PND) 2, drinking water only or drinking water containing dipyrone at doses of 100, 300, and 500mg/kg/day, were offered to lactating mothers up to PND9. Thereafter, all mice were provided regular drinking water. On PND2, all litters were culled to 8 pups (4 males and 4 females). Maternal behavior was evaluated at PND3, 6, 9, and 12, and at PND7 we evaluated locomotor activity in the open field. Reflex parameters and physical development of offspring were evaluated during lactation. At PND7, analysis of ultrasonic vocalization (USV) was performed. When the animals reached adolescence, we evaluated their performance in the open field, elevated plus maze (EPM), and marble burying. Our data demonstrated that maternal dipyrone treatment during lactation not only altered maternal behavior and the onset of physical and neurodevelopmental landmarks but also had an impact on anxiety-like behavior in offspring.

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Prenatal exposure to a low fipronil dose disturbs maternal behavior and reflex development in rats

Cited by 40 publications

References 31 publications

An update of the Worldwide Integrated Assessment (WIA) on systemic insecticides. Part 2: impacts on organisms and ecosystems

An update of the Worldwide Integrated Assessment (WIA) on systemic insecticides. Part 2: impacts on organisms and ecosystems

Reproductive and Neurobehavioral Effects of Ethiprole Administered to Mice in the Diet

Maternal dipyrone treatment during lactation in mice reduces maternal behavior and increases anxiety‐like behavior in offspring

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