Prenatal disruption of blood–brain barrier formation via cyclooxygenase activation leads to lifelong brain inflammation

Zhao, Qiuying; Dai, Weiye; Chen, Hui-Yu; Jacobs, Russell E.; Zloković, Berislav V.; Lund, Brett T.; Montagne, Axel; Bonnin, Alexandre

doi:10.1073/pnas.2113310119

Cited by 18 publications

(20 citation statements)

References 69 publications

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“…Early prenatal injury can result in the embryo’s mortality. On other hand, insufficient growth (agenesis of the corpus callosum or anencephaly) or abnormal development (lissencephaly or microcephaly) could be the possible outcomes of late injuries [ 75 , 76 , 77 , 78 ]. During a period of heightened development, trauma (such as fetal stroke in the womb or damage to the mother) will result in more structural issues than when progression has slowed or has ended.…”

Section: Mechanism Of Abimentioning

confidence: 99%

Understanding Acquired Brain Injury: A Review

et al. 2022

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Any type of brain injury that transpires post-birth is referred to as Acquired Brain Injury (ABI). In general, ABI does not result from congenital disorders, degenerative diseases, or by brain trauma at birth. Although the human brain is protected from the external world by layers of tissues and bone, floating in nutrient-rich cerebrospinal fluid (CSF); it remains susceptible to harm and impairment. Brain damage resulting from ABI leads to changes in the normal neuronal tissue activity and/or structure in one or multiple areas of the brain, which can often affect normal brain functions. Impairment sustained from an ABI can last anywhere from days to a lifetime depending on the severity of the injury; however, many patients face trouble integrating themselves back into the community due to possible psychological and physiological outcomes. In this review, we discuss ABI pathologies, their types, and cellular mechanisms and summarize the therapeutic approaches for a better understanding of the subject and to create awareness among the public.

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Section: Mechanism Of Abimentioning

confidence: 99%

Understanding Acquired Brain Injury: A Review

et al. 2022

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“…Zhao et al. ( 5 ) show that a subset of microglia express COX2 and in response to MIA this COX2+ population expands, becomes perivascular, and is associated with BBB disruption ( Fig. 1 ).…”

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confidence: 94%

“…In PNAS, Zhao et al. ( 5 ) demonstrate that MIA is associated with increased blood–brain barrier (BBB) permeability and microglial activation in the offspring, leading to an inflammatory response in the fetal brain that persists into adulthood.…”

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confidence: 99%

“…Here, Zhao et al. ( 5 ) tested the hypothesis that MIA-induced microglial activation and inflammation disrupt the development of the BBB in the fetus, leading to hyperpermeability and to a long-lasting fetal inflammatory response that persist into adulthood.…”

mentioning

confidence: 99%

“…To this end, Zhao et al. ( 5 ) utilized the polyinosinic:polycytidylic acid (polyI:C) model, injecting pregnant dams at embryonic day (E) 13.5 to induce MIA. They confirmed the induction of expected phenotypes in both the mother and offspring, including increased cytokine concentration in maternal blood serum, increased activated microglia, and anxiety and memory deficits in the adult offspring.…”

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confidence: 99%

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