Prenatal dioxin exposure estimated from dioxins in breast milk and sex hormone levels in umbilical cord blood in Vietnamese newborn infants

Boda, Hitomi; Nghi, Tran Ngoc; Nishijo, Muneko; Thao, Pham Ngoc; Luong, Hoang Van; Anh, Tran Hai; Morikawa, Yuko; Nishino, Yoshikazu; Nishijo, Hisao

doi:10.1016/j.scitotenv.2017.09.214

Cited by 28 publications

(17 citation statements)

References 23 publications

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“…T facilitates binding to SHBG compared with E2, and an increase in SHBG level suppresses T activity. In our study, maternal mono-ortho PCBs were positively associated with SHBG level, which is related to T activity; two previous studies have indicated the possibility that decreased cord blood T levels related with prenatal exposure to PCDD/PCDFs were more pronounced among females (Boda et al, 2018;Hsu et al, 2005). Therefore, our results were partly consistent with results of these two previous studies.…”

Section: Discussionsupporting

confidence: 92%

Sex-related differences in the associations between maternal dioxin-like compounds and reproductive and steroid hormones in cord blood: The Hokkaido study

Miyashita

Araki

Mitsui

et al. 2018

Environment International

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Section: Discussionsupporting

confidence: 92%

Sex-related differences in the associations between maternal dioxin-like compounds and reproductive and steroid hormones in cord blood: The Hokkaido study

Miyashita

Araki

Mitsui

et al. 2018

Environment International

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“…For PCDD/Fs, the mean TEQ of 13.96 pg·g −1 lipid in our study was lower than the TEQ (mean 14.5 pg·g −1 lipid) in cord serum in a Vietnamese study reported by Boda et al [42]. Our observations also indicate that the TEQ of dl-PCBs (mean 2.14 pg·g −1 lipid) in cord serum was similar to what was found in a Japanese study (mean 2.4 pg·g −1 lipid [8]).…”

Section: Resultscontrasting

confidence: 90%

Polychlorinated Dibenzo-p-Dioxins, Polychlorinated Dibenzofurans, and Dioxin-Like Polychlorinated Biphenyls in Umbilical Cord Serum from Pregnant Women Living Near a Chemical Plant in Tianjin, China

Liu

Xiao

et al. 2019

IJERPH

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Polychlorinated dibenzo-p-dioxins, polychlorinated dibenzofurans (PCDD/Fs), and dioxin-like polychlorinated biphenyls (dl-PCBs) are bioaccumulative compounds that may affect fetal growth and infant development. The aim of this study was to determine whether the pregnant women living near a chemical plant in Tianjin had a risk of exposure to dioxins. Concentrations of PCDD/Fs and dl-PCBs in 24 umbilical cord serum samples collected from pregnant women were measured using a high-resolution gas chromatograph with a high-resolution mass spectrometer (HRGC-HRMS) and an isotopic dilution method. The levels of ∑(PCDD/Fs + dl-PCBs) were in the range 476–8307 pg·g−1 lipid, with a mean of 3037 pg·g−1. The mean World Health Organization toxicity equivalent (WHO-TEQ) for PCDD/Fs and dl-PCBs was 14.0 and 2.14 pg·g−1 lipid, respectively. The PCDD/Fs and dl-PCBs contributed 86.7% and 13.3%, respectively, to the total TEQ. The octa-CDFs and penta-CBs were predominant for the PCDD/Fs and dl-PCBs, accounting for 57.6% and 74.3%, respectively. Several PCDD/F and dl-PCB congeners were highly correlated, such as PCB 105 and PCB 118 (r = 0.982, p < 0.001). Although the results hint at decreasing trends for PCDD/F and dl-PCBs by comparison with a similar study in Tianjin, a total TEQ of 41.7% of study participants had a body burden that exceeded the biomonitoring equivalents for dioxins. It was shown that pregnant women and infants had a health risk of exposure to dioxins.

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“…To explore the role of the AhR in TCDD exposure, Fukuzawa et al [97] examined the testis and found LHR levels decreased in male mice in comparison to AhR-null mice. In human males, Boda et al [98] found that exposure to TCDD can occur through breast milk. Adulthood exposure to TCDD appears to have no significant effect on sex hormone levels or sperm variables such as sperm count, progressive sperm motility, and total number of motile sperm while infancy and prepubertal exposure does [99].…”

Section: Discussionmentioning

confidence: 99%

Section: Male-specific Responsesmentioning

confidence: 96%

“…Boda et al [98] found a high correlation between 2,3,7,8-TCDD concentrations in cord blood and breast milk. This finding suggests that the levels found in breast milk represent the levels of TCDD exposure prenatally [98]. A reduction in testosterone in cord blood was seen in >/= 5.5 pg/g lipid 2,3,7,8-TCDD exposure in boys prenatally [98].…”

Section: Male-specific Responsesmentioning

confidence: 96%

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Endocrine-Disrupting Air Pollutants and Their Effects on the Hypothalamus-Pituitary-Gonadal Axis

Plunk

Richards

2020

IJMS

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Anthropogenic endocrine-disrupting chemicals (EDCs) can contaminate air, soil, and water. Human exposures to EDCs occur through inhalation, absorption, and ingestion. EDCs act by disrupting various pathways in the endocrine system. When the hypothalamic–pituitary–gonadal (HPG) axis is disrupted by EDCs, there can be effects on fertility in both men and women. Not only can fertility be indirectly affected by EDC disruptions of the HPG axis, but EDCs can also directly affect the menstrual cycle and sperm morphology. In this review, we will discuss the current findings on EDCs that can be inhaled. This review examines effects of exposure to prominent EDCs: brominated and organophosphate flame retardants, diesel exhaust, polycyclic aromatic hydrocarbons, cadmium and lead, TCDD, and polychlorinated biphenyls on fertility through alterations that disrupt the HPG axis and fertility through inhalation. Although the studies included herein include multiple exposure routes, all the studies indicate receptor interactions that can occur from inhalation and the associated effects of all compounds on the HPG axis and subsequent fertility.

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Prenatal dioxin exposure estimated from dioxins in breast milk and sex hormone levels in umbilical cord blood in Vietnamese newborn infants

Cited by 28 publications

References 23 publications

Sex-related differences in the associations between maternal dioxin-like compounds and reproductive and steroid hormones in cord blood: The Hokkaido study

Sex-related differences in the associations between maternal dioxin-like compounds and reproductive and steroid hormones in cord blood: The Hokkaido study

Polychlorinated Dibenzo-p-Dioxins, Polychlorinated Dibenzofurans, and Dioxin-Like Polychlorinated Biphenyls in Umbilical Cord Serum from Pregnant Women Living Near a Chemical Plant in Tianjin, China

Endocrine-Disrupting Air Pollutants and Their Effects on the Hypothalamus-Pituitary-Gonadal Axis

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