Prenatal dioxin exposure and neurocognitive development in Hong Kong 11-year-old children

Hui, Lucas Chi Kwong; Lam, Hugh Simon; Lau, Esther Yuet Ying; Wong, Tze Wai; Fielding, Richard

doi:10.1016/j.envres.2016.06.003

Cited by 13 publications

(3 citation statements)

References 39 publications

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“…In a study on 11‐year‐old children from Hong Kong with low level prenatal exposure, no association between exposure and neurocognitive function was found (Hui et al., ).…”

Section: Assessmentmentioning

confidence: 99%

Risk for animal and human health related to the presence of dioxins and dioxin‐like PCBs in feed and food

Knutsen¹,

Alexander²,

Barregård³

et al. 2018

EFS2

137

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The European Commission asked EFSA for a scientific opinion on the risks for animal and human health related to the presence of dioxins (PCDD/Fs) and DL‐PCBs in feed and food. The data from experimental animal and epidemiological studies were reviewed and it was decided to base the human risk assessment on effects observed in humans and to use animal data as supportive evidence. The critical effect was on semen quality, following pre‐ and postnatal exposure. The critical study showed a NOAEL of 7.0 pg WHO2005‐TEQ/g fat in blood sampled at age 9 years based on PCDD/F‐TEQs. No association was observed when including DL‐PCB‐TEQs. Using toxicokinetic modelling and taking into account the exposure from breastfeeding and a twofold higher intake during childhood, it was estimated that daily exposure in adolescents and adults should be below 0.25 pg TEQ/kg bw/day. The CONTAM Panel established a TWI of 2 pg TEQ/kg bw/week. With occurrence and consumption data from European countries, the mean and P95 intake of total TEQ by Adolescents, Adults, Elderly and Very Elderly varied between, respectively, 2.1 to 10.5, and 5.3 to 30.4 pg TEQ/kg bw/week, implying a considerable exceedance of the TWI. Toddlers and Other Children showed a higher exposure than older age groups, but this was accounted for when deriving the TWI. Exposure to PCDD/F‐TEQ only was on average 2.4‐ and 2.7‐fold lower for mean and P95 exposure than for total TEQ. PCDD/Fs and DL‐PCBs are transferred to milk and eggs, and accumulate in fatty tissues and liver. Transfer rates and bioconcentration factors were identified for various species. The CONTAM Panel was not able to identify reference values in most farm and companion animals with the exception of NOAELs for mink, chicken and some fish species. The estimated exposure from feed for these species does not imply a risk.

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“…In a study on 11‐year‐old children from Hong Kong with low level prenatal exposure, no association between exposure and neurocognitive function was found (Hui et al., ).…”

Section: Assessmentmentioning

confidence: 99%

Risk for animal and human health related to the presence of dioxins and dioxin‐like PCBs in feed and food

Knutsen¹,

Alexander²,

Barregård³

et al. 2018

EFS2

137

View full text Add to dashboard Cite

show abstract

“…Studies in human suggest dioxins and dioxin-like exposure were associated with lower motor skills (Gladen et al 1988 (Pham et al 2015), and attention performance (Neugebaueret al 2015). Other studies suggested a negative association between dioxins and dioxin-like exposure with socioemotional and behavior (Konoet al 2015), and motor and cognitive skills (Nakajima et al 2006;Wilhelm et al 2008;Hui et al 2016). To elucidate varied results, a review study shall be conducted.…”

Section: Introductionmentioning

confidence: 95%

Effects of Dioxins (PCDDs, PCDFs) and Dioxin-like (PCBs) Exposure on Neuro-development in Children: A Review

Prabaningrum¹

2019

KLS

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“…As they are inevitably present in the human body and are found in residual concentrations in breast milk, there are concerns about infants’ exposure. The chronic exposure of humans to POPs is a major health concern as it can have a wide variety of harmful consequences, including reproductive and developmental effects [ 3 , 4 ], neurological and behavioral effects [ 5 , 6 ] or autism [ 7 , 8 ], dermal toxicity [ 9 ], and carcinogenicity [ 10 ], in addition to metabolic syndrome and obesity [ 11 ].…”

Section: Introductionmentioning

confidence: 99%

Levels of Polychlorinated Dibenzo-p-Dioxins/Furans (PCDD/Fs) and Dioxin-Like Polychlorinated Biphenyls (DL-PCBs) in Human Breast Milk in Chile: A Pilot Study

Foerster

Zúñiga-Venegas

Enríquez

et al. 2021

IJERPH

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Persistent organic pollutants (POPs) are organic compounds that resist biochemical degradation, moving long distances across the atmosphere before deposition occurs. Our goal was to provide up-to-date data on the levels of polychlorinated dibenzo-p-dioxins/furans (PCDD/Fs) and dioxin-like polychlorinated biphenyls (DL-PCBs) in breast milk from Chilean women and to estimate the exposure of infants due to breast milk consumption. In Chile, we conducted a cross-sectional study based on methodologies proposed by the WHO, with a sample of 30 women recruited from three defined areas: 10 from the Arica Region (urban; Arica and Parinacota Region), 10 from Coltauco (rural; O’Higgins Region), and 10 from Molina (40% rural; Maule Region). High-resolution gas chromatography coupled with high-resolution mass spectrometry (HRGC/HRMS) was performed on pooled samples from each area. We calculated equivalent toxic concentrations (WHO-TEQ) based on the current WHO Toxic Equivalency Factors (TEF). The minimum and maximum values of ∑ PCDDs/Fs + DL-PCBs-TEQ were 4.317 pg TEQ/g fat in Coltauco and 6.31 pg TEQ/g fat in Arica. Molina had a total TEQ of 5.50 pg TEQ/g fat. The contribution of PCDD/Fs was approximately five-fold higher than that of DL-PCBs. The Estimated Daily Intake (EDI) of ∑ PCDDs/Fs + DL-PCBs based on the three pooled samples ranged between 6.71 and 26.28 pg TEQ/kg body weight (bw)/day, with a mean intake of 16.11 (±6.71) pg TEQ/kg bw/day in breastfed children from 0 to 24 months old. These levels were lower than those reported in international studies. Despite the fact that the observed levels were low compared to those in most industrialized countries, the detection of a variety of POPs in breast milk from Chilean women indicates the need for follow-up studies to determine whether such exposures during childhood could represent a health risk in adulthood.

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Prenatal dioxin exposure and neurocognitive development in Hong Kong 11-year-old children

Cited by 13 publications

References 39 publications

Risk for animal and human health related to the presence of dioxins and dioxin‐like PCBs in feed and food

Risk for animal and human health related to the presence of dioxins and dioxin‐like PCBs in feed and food

Effects of Dioxins (PCDDs, PCDFs) and Dioxin-like (PCBs) Exposure on Neuro-development in Children: A Review

Levels of Polychlorinated Dibenzo-p-Dioxins/Furans (PCDD/Fs) and Dioxin-Like Polychlorinated Biphenyls (DL-PCBs) in Human Breast Milk in Chile: A Pilot Study

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