Prenatal diagnosis of persistent left superior vena cava and its associated congenital anomalies

Berg, Christoph; Knüppel, M.; Geipel, A.; Kohl, Thomas; Krapp, M.; Knöpfle, G; Germer, U.; Hansmann, M.; Gembruch, Ulrich

doi:10.1002/uog.2704

Cited by 89 publications

(103 citation statements)

References 19 publications

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“…In our previous study, we found that it increased the odds of congenital heart disease to 8.43 and was seen in half of the cases of coarctation requiring surgery. [17][18][19] We have included the fetuses from this early experience in this study. In this current cohort, half of the fetuses with a persistent left superior caval vein did not have coarctation or arch hypoplasia after birth, and its detection decreased the likelihood of requiring surgery for coarctation to 0.35.…”

Section: Screening For Fetal Coarctationmentioning

confidence: 99%

Morphological and Physiological Predictors of Fetal Aortic Coarctation

et al. 2008

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Background-Prenatal diagnosis of aortic coarctation suffers from high false-negative rates at screening and poor specificity. Methods and Results-This retrospective study tested the applicability of published aortic arch and ductal Z scores (measured just before the descending aorta in the 3-vessel and tracheal view) and their ratio on 200 consecutive normal controls at a median of 22Ϯ0 gestational weeks (range, 15Ϯ4 to 38Ϯ4 weeks). Second, this study tested the ability of serial Z scores to distinguish fetuses with coarctation within a cohort with ventricular and/or great arterial disproportion detected at screening or fetal echocardiography. Third, it evaluated the diagnostic significance of associated cardiac lesions, coarctation shelf, and isthmal flow disturbance. We studied 44 fetuses with suspected coarctation at 24Ϯ0 weeks (range, 17Ϯ3 to 37Ϯ4 weeks). Receiver-operating characteristic curves were created. Logistic regression tested the association between z scores, additional cardiac diagnoses, and coarctation. Good separation was found of isthmal Z scores for cases requiring surgery from controls and false-positive cases, and receiver-operating characteristic curves showed an excellent area under the curve for isthmal Z score (0.963) and isthmal-to-ductal ratio (0.969). Serial isthmal Z scores improved to ϾϪ2 in suspected cases with normal outcomes; those requiring surveillance or surgery remained ϽϪ2. Minor lesions did not increase the diagnostic specificity of coarctation, but isthmal flow disturbance increased the odds ratio of true coarctation versus arch hypoplasia 16-fold. Conclusions-Isthmal

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Section: Screening For Fetal Coarctationmentioning

confidence: 99%

Morphological and Physiological Predictors of Fetal Aortic Coarctation

et al. 2008

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“…A dilated CS may also be misdiagnosed as an ostium primum ASD and abnormal pulmonary venous connection has to be ruled out. CoAo is associated, to a certain degree, with the presence of a dilated CS 8,9 but its prenatal diagnosis remains challenging 10 , and CoAo was not confirmed in this case. All of these possible diagnoses have a different prognosis, therefore an exact differentiation in the prenatal period is warranted.…”

Section: Letters To the Editor Prenatal Diagnosis Of Isolated Total Amentioning

confidence: 72%

Unusual cardiac presentation of congenital cytomegalovirus infection

Barnett¹,

Jaeggi²,

Han³

et al. 2009

Ultrasound in Obstet & Gyne

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“…sign in a slightly oblique left parasagittal view, showing the LSVC draining into a dilated coronary sinus 5 (Figure 4) This view is described in pediatric echocardiography and was reproduced in fetal echocardiography by Freund, et al (2008) 5 . An isolated enlarged coronary sinus (Figure 5) is highly suggestive of persistent LSVC, although this finding may have both false positive and false negative diagnoses 3 28 – 35 …”

Section: Discussionmentioning

confidence: 83%

Persistent left superior vena cava – considerations in fetal, pediatric and adult populations

Saha

Paoletti

Robertson³

2012

Australas J Ultrason Med

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Persistent left superior vena cava (LSVC) is the commonest congenital anomaly of the thoracic venous system. It is within the group of anomalous systemic venous return (ASVR) and the group is subdivided in cephalic, involving the superior vena cava (SVC) and caudal, involving the inferior vena cava (IVC) types. It is also important to recognise that there can be a persistent LSVC with or without a normal right superior vena cava (RSVC). In most cases, a persistent LSVC drains into the right atrium via the coronary sinus without any clinical symptoms. In this article we discuss embryology, diagnostic and further management approaches and a review of the literature related to persistent LSVC.

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Prenatal diagnosis of persistent left superior vena cava and its associated congenital anomalies

Abstract: Objective

Cited by 89 publications

References 19 publications

Morphological and Physiological Predictors of Fetal Aortic Coarctation

Morphological and Physiological Predictors of Fetal Aortic Coarctation

Unusual cardiac presentation of congenital cytomegalovirus infection

Persistent left superior vena cava – considerations in fetal, pediatric and adult populations

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