Prenatal Diagnosis of Intracranial Teratoma

Ferreira, José Antonio González; Eviatar, Lydia; Schneider, Steven J.; Grossman, Rami

doi:10.1159/000120706

Cited by 31 publications

(12 citation statements)

References 10 publications

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“…The prognosis worsens with increase in tumor size and decrease in gestational age at diagnosis. The longest survival which has been reported after excision is 18 months and was associated with severe developmental delay and cortical blindness [12]. Of note, the diagnosis in that case was made at 37 weeks of gestation, and the infant had an essentially normal examination at birth.…”

Section: Discussionmentioning

confidence: 80%

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Massive Intracranial Immature Teratoma with Extracranial Extension into Oral Cavity, Nose, and Neck

Alagappan

Shattuck²,

Rowe

et al. 1998

Fetal Diagn Ther

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We present a case of congenital massive intracranial teratoma with extracranial extension into oral cavity, nose, and neck diagnosed by antenatal ultrasonography at 25 weeks of gestation. The fetus was delivered by cesarean section because of massive fetal head size and severe maternal pregnancy-induced hypertension. At necropsy the tumor was found to be an immature teratoma, with no recognizable normal brain tissue. An additional finding was hepatomegaly secondary to extensive extramedullary hematopoiesis. Karyotyping of both the fetus and the teratoma revealed a normal female chromosomal composition: 46,XX.

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Section: Discussionmentioning

confidence: 80%

“…Almost all infants with antenatally diagnosed intracranial teratomas die before or shortly after delivery (mean survival 21 days) [12]. The prognosis worsens with increase in tumor size and decrease in gestational age at diagnosis.…”

Section: Discussionmentioning

confidence: 99%

Massive Intracranial Immature Teratoma with Extracranial Extension into Oral Cavity, Nose, and Neck

Alagappan

Shattuck²,

Rowe

et al. 1998

Fetal Diagn Ther

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“…In a patient with congenital cerebellar teratoma, diagnosis may be prenatal or postnatal [17]. Prenatal diagnosis has increased compared to the past due to better prenatal follow-up and excellent radiological workups [17]. Diagnosis can be suspected on routine fetal ultrasound examination [17].…”

Section: Discussionmentioning

confidence: 99%

Infratentorial immature teratoma of congenital origin can be associated with a 20-year survival outcome: a case report and review of literature

2019

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BackgroundCongenital intracranial tumors are very rare and account for less than 2% of all childhood brain tumors. Teratomas constitute about one third to one half of these, predominantly located midline in the supratentorial region. Posterior fossa location rarely occurs and, based on the cases reported in the literature, commonly has a poor prognosis.Case presentationA newborn female, diagnosed prenatally with hydrocephalus, is presented at birth with increasing head circumference and Parinaud’s syndrome. Magnetic resonance imaging scans demonstrated a huge posterior fossa tumor with obstructive hydrocephalus. At surgery, through a suboccipital craniotomy, complete excision was achieved of a histological-proven immature teratoma. The infant received adjuvant chemotherapy for 1 year. She had normal neurological development and remained tumor-free through her 20-year follow-up.ConclusionThe authors report this rare case of congenital posterior fossa teratoma with long-term outcome, and the literature is reviewed.

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“…Congenital intracranial teratomas have a poor prognosis because of rapid, invasive growth of the tumor and destruction of the normal brain [5]. The treatment includes radical surgical resection of the tumor, followed by either radiotherapy and/or chemotherapy [6].…”

Section: Discussionmentioning

confidence: 99%

“…Immature teratomas may show widely varying responses to adjuvant therapy, leading to striking differences in disease-free survival after the same therapeutic regimens. The overall 5-year survival rate was reported to be 18% in a case series [5]. …”

Section: Discussionmentioning

confidence: 99%

Congenital Immature Teratoma Mimicking Cushing’s Disease

Salunke

Bhansali²,

Dutta³

et al. 2010

Pediatr Neurosurg

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Cushing’s disease in a neonate is rare and has been reported secondary to pituitary macroadenoma. A case of Cushing’s syndrome due to congenital immature teratoma in the region of the pituitary has never been reported. We discuss a case of a neonate who presented with Cushing’s syndrome secondary to a congenital immature teratoma in sellar, suprasellar and parasellar regions with ectopic ACTH secretion, thereby mimicking Cushing’s disease. The management issues and prognosis of congenital teratomas and neonatal Cushing’s syndrome have been discussed. We describe the first case of intracranial ectopic ACTH secreting teratoma in a young infant. The prognosis is usually bad unless total excision is achieved. In the preoperative period and in case of subtotal excision, chemotherapy to take care of hypercortisolemia may be given.

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Prenatal Diagnosis of Intracranial Teratoma

Cited by 31 publications

References 10 publications

Massive Intracranial Immature Teratoma with Extracranial Extension into Oral Cavity, Nose, and Neck

Massive Intracranial Immature Teratoma with Extracranial Extension into Oral Cavity, Nose, and Neck

Infratentorial immature teratoma of congenital origin can be associated with a 20-year survival outcome: a case report and review of literature

Congenital Immature Teratoma Mimicking Cushing’s Disease

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