Prenatal Diagnosis of Congenital Mesoblastic Nephroma in 2 Siblings

Fuchs, Ilka; Henrich, Wolfgang; Bräuer, Martin; Stöver, B.; Guschmann, M.; Degenhardt, P.; Dudenhausen, Joachim W.

doi:10.7863/jum.2003.22.8.823

Cited by 25 publications

(16 citation statements)

References 17 publications

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“…Cytogenetic abnormalities such as trisomy 11 occur sporadically (23, 24). However, Fuchs et al reported a case of CMN occurring in two siblings within one family and suggested that a second-trimester anomaly scan with targeted examination of the kidneys is warranted in families with a child affected by CMN (25). …”

Section: Discussionmentioning

confidence: 99%

A Case of Fetal Congenital Mesoblastic Nephroma with Oligohydramnios

Kim

Cho

et al. 2007

J Korean Med Sci

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Although congenital renal tumors are rare, congenital mesoblastic nephroma (CMN) is the most common renal tumor in early infancy. It is non-metastatic, well differentiated, amenable to surgical removal, and carries a good prognosis. Polyhydramnios has been detected in most of the published cases of CMN. However, we experienced a rare case of fetal CMN associated with oligohydramnios. A 28-yr old woman at 34 weeks of gestation was referred to our hospital for oligohydramnios and a fetal abdominal mass. An ultrasonography revealed a huge, well-encapsulated mass arising from the right kidney. An emergency cesarean section was performed due to fetal distress. After birth, despite intensive neonatal care, the baby died because of renal failure, disseminated intravascular coagulopathy, pulmonary edema, together with other problems

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Section: Discussionmentioning

confidence: 99%

A Case of Fetal Congenital Mesoblastic Nephroma with Oligohydramnios

Kim

Cho

et al. 2007

J Korean Med Sci

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“…The main factor of importance as a risk factor for local recurrence is incomplete excision at primary surgery, and for this reason such lesions should not undergo prenatal biopsy, which may breach the capsule. Prenatal diagnosis of mesoblastic nephroma is well reported and it appears as a solid or cystic renal mass on ultrasound or magnetic resonance imaging (MRI)40, 41; it may also be associated with polyhydramnios42 and rarely oligohydramnios43, neonatal hypertension44 and even fetal hydrops and intrauterine death45, 46.…”

Section: Fetal Malignanciesmentioning

confidence: 99%

Metal Ion Coordination to Azole Nucleosides

Müller

Böhme

Lax

et al. 2005

Chemistry A European J

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To evaluate the possibility of introducing azole nucleosides as building blocks for metal-mediated base pairs in artificial oligonucleotides, imidazole nucleoside, 1,2,4-triazole nucleoside and tetrazole nucleoside have been synthesized and characterized. The X-ray crystal structures of p-toluoyl-protected 1,2,4-triazole and tetrazole nucleosides are reported. Contrary to the situation primarily found for deoxyribonucleosides, the sugar moieties adopt C3'-endo conformations. The acidity of the beta nucleosides increases with increasing number of nitrogen ring atoms, giving pKa values of 6.01 +/- 0.05, 1.32+/-0.05 and <-3, respectively. This decrease in basicity results in a decreasing ability to form 2:1 complexes with linearly coordinating metal ions such as Ag+ and Hg2+. In all cases, the Ag+ complexes are of higher stability than the corresponding Hg2+ complexes. Whereas imidazole nucleoside forms highly stable 2:1 complexes with both metal ions (estimated log beta2 values of >10), only Ag+ is able to reach this coordination pattern in the case of triazole nucleoside (log beta2 = 4.3 +/- 0.1). Tetrazole nucleoside does not form 2:1 complexes at all under the experimental conditions used. These data suggest that imidazole nucleoside, and to a lesser extent 1,2,4-triazole nucleoside, are likely candidates for successful incorporation as ligands in oligonucleotides based on metal-mediated base pairs. DFT calculations further corroborate this idea, providing model complexes for such base pairs with glycosidic bond distances (10.8-11.0 Angstroms) resembling those in idealized B-DNA (10.85 Angstroms).

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“…Based on these findings and the fact that there was no known cause for the gastrointestinal signs before surgery, it is postulated that the clinical signs in the present case could be associated with decreased peristalsis due to the presence of the adhesion. In humans, one case of familial congenital mesoblastic nephroma has been described in two siblings (Fuchs and others ). The progeny of the dog presented here was ultrasonographically monitored for a period lasting one‐and‐a‐half years without any evidence of renal masses, and its parents and siblings reportedly did not show any signs of renal disease.…”

Section: Discussionmentioning

confidence: 99%

Congenital mesoblastic nephroma in a young basset hound dog

Soldati¹,

Radælli

Mazzuti³

et al. 2012

J of Small Animal Practice

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An 18-month-old male basset hound was presented with vomiting, diarrhoea and depression. Abdominal ultrasonography revealed a mass in the left kidney. An ultrasound-guided core-biopsy indicated aggregates of spindle cells, but did not allow a definitive diagnosis. Nephrectomy was performed after a period of six months, when ultrasound examination revealed a slight increase in mass dimensions. Histologically the mass was composed of neoplastic spindle cells forming interlacing fascicles, bundles and whorls, within a loose myxoid to dense collagenous stroma. Immunohistochemically neoplastic cells were positive for vimentin and smooth muscle actin. Based on these findings the tumour was diagnosed as a congenital mesoblastic nephroma, classical variant. After a two-and-a-half-year follow-up the dog was clinically healthy, indicating a benign behaviour. To the authors' knowledge, this report describes the first case of canine congenital mesoblastic nephroma successfully treated surgically, with a reasonable postsurgical follow-up.

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Prenatal Diagnosis of Congenital Mesoblastic Nephroma in 2 Siblings

Cited by 25 publications

References 17 publications

A Case of Fetal Congenital Mesoblastic Nephroma with Oligohydramnios

A Case of Fetal Congenital Mesoblastic Nephroma with Oligohydramnios

Metal Ion Coordination to Azole Nucleosides

Congenital mesoblastic nephroma in a young basset hound dog

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