Prenatal diagnosis of congenital high airway obstruction syndrome (CHAOS). Five case report.

Aslan, Halıl; Ekiz, Ali; Açar, Deniz; Aydıner, Burçhan; Kaya, Başak; Sezer, Salim

doi:10.11152/mu.2013.2066.171.haek

Cited by 21 publications

(20 citation statements)

References 8 publications

(8 reference statements)

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“…4 CHAOS may be also a part of Cri-duChat syndrome, short-rib polydactyly syndrome, and velocardiofacial syndrome. 6 Apart from this, a case of CHAOS with autosomal dominant inheritance of the father and his two affected children was reported. The point to take into consideration is the necessity of a detailed evaluation of all CHAOS suspected cases due to possibility of coexistence of any genetic syndrome and significant implications of inheritance for future pregnancies.…”

Section: Discussionmentioning

confidence: 98%

“…The point to take into consideration is the necessity of a detailed evaluation of all CHAOS suspected cases due to possibility of coexistence of any genetic syndrome and significant implications of inheritance for future pregnancies. 4,6 CHAOS is most often misdiagnosed as bilateral congenital cystic adenomatoid malformation (CCAM). CCAM (especially type III) and upper airway obstruction secondary to intrinsic causes such as tracheal or laryngeal atresia or stenosis and tracheal webs similarly have bilateral uniform hyper echogenic appearance of the foetal lungs on sonographic examination.…”

Section: Discussionmentioning

confidence: 99%

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A rare case report of congenital high airway obstruction syndrome presenting in a 23 weeks foetus

Kanchana

Sellamuthu

Mahendran

2018

Int J Reprod Contracept Obstet Gynecol

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Congenital High Airway Obstruction Syndrome or CHAOS is a blockage of the foetus’s trachea or larynx due to many factors including narrowing of the airway, a web-like membrane or even tracheal atresia. In the uterus, the foetal lungs constantly produce fluid and as a result of this airway blockage in the trachea, the lung fluid cannot escape out of the foetal mouth. Because of this the foetus’s lungs become distended with fluid and over distended lungs can put pressure on the heart and affect the heart’s ability to function. If the heart cannot function effectively hydrops or congestive heart failure can occur. We present a rare case of CHAOS diagnosed prenatally at about 23 weeks by USG in our hospital.

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Section: Discussionmentioning

confidence: 98%

Section: Discussionmentioning

confidence: 99%

A rare case report of congenital high airway obstruction syndrome presenting in a 23 weeks foetus

Kanchana

Sellamuthu

Mahendran

2018

Int J Reprod Contracept Obstet Gynecol

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“…The main diagnostic tool for prenatal diagnosis of CHAOS is sonography. US characteristic findings are bilateral large hyperechoic lungs, dilated tracheobronchial tree, small, compressed, and centrally replaced heart, flattened or inverted diaphragm, and ascites (6). Compression of the esophagus due to dilated trachea may result in polyhydramnios.…”

Section: Discussionmentioning

confidence: 99%

Congenital high airway obstruction syndrome (CHAOS): discussing the role and limits of prenatal diagnosis starting from a single-center case series

Vitale¹

2016

JPM

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Objectives: we aimed to report our experience about congenital high airway obstruction syndrome (CHAOS) that is a rare and fatal congenital anomaly; laryngeal atresia is the most frequent cause. Sonographic findings are enlarged echogenic lungs, dilated trachea, and ascites. Methods: we performed a single-center case series analysis collecting antenatally through ultrasound examination, and some of them confirmed by autopsy. Results: we report six cases of CHAOS diagnosed by antenatal ultrasonography between 2007 and 2013. Conclusion: to date literature provides very few individual case reports. This work describes typical sonographic findings of this syndrome and it underlines the importance of early prenatal diagnosis to improve prognosis thought an ex utero intrapartum treatment, that seems to be the only chance of survival for the affected fetus.Key words: congenital high airway obstruction, prenatal diagnosis, diagnosis, prognosis. IntroductionCongenital high airway obstruction syndrome (CHAOS) is an extremely rare congenital anomaly, caused by laryngeal or tracheal atresia, tracheal stenosis, obstructing laryngeal cysts and obstructing tumors of the oropharynx and the cervical region, or rarely by compression from a double aortic arch (1). Laryngeal atresia seems to be the most frequent cause (2). In these cases, an outflow obstruction of the fetal lung fluid leads to pulmonary hyperplasia. Prenatal ultrasound findings are very characteristic and include lungs symmetrically enlarged and highly echogenic, dilated and fluid-filled trachea and bronchi, inverted hemidiaphragms (3). The heart appears small compared with the enlarged lungs and positioned towards the midline of the thorax due to compression by the lungs. Fetal ascites is often present and sometimes hydrops. MethodsWe report our experience of six cases of CHAOS, diagnosed antenatally through ultrasound examination, and some of them confirmed by autopsy.

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“…Es una lesión vascular formada por la conexión anormal entre arteria y vena. La localización más frecuente es a nivel de la pelvis, involucrando ocasionalmente al útero 1 .…”

Section: Introduccionunclassified

Malformacion uterina arteriovenosa

Ramirez

Montero

Barchello

et al. 2016

Rev. Nac. (Itauguá)

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Prenatal diagnosis of congenital high airway obstruction syndrome (CHAOS). Five case report.

Cited by 21 publications

References 8 publications

A rare case report of congenital high airway obstruction syndrome presenting in a 23 weeks foetus

A rare case report of congenital high airway obstruction syndrome presenting in a 23 weeks foetus

Congenital high airway obstruction syndrome (CHAOS): discussing the role and limits of prenatal diagnosis starting from a single-center case series

Malformacion uterina arteriovenosa

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