Prenatal Diagnosis of Congenital Hepatoblastoma

Wang, Jiayan; Zheng, Qing‐Shui; Cao, Dingya; Xie, Yuan; Song, Ting; Jiang, Qingping; Chen, Min

doi:10.1097/fm9.0000000000000022

Cited by 3 publications

(3 citation statements)

References 14 publications

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“…Primary liver tumors account for 1–2% of all childhood tumors [ 9 , 10 ]. Hepatoblastoma is a malignant liver tumor in young children that accounts for more than 90% of liver cancers in children under 5 years of age [ 11 ].…”

Section: Discussionmentioning

confidence: 99%

Giant pedunculated hepatoblastoma mimicking neuroblastoma in a 4-month-old infant: a case report

et al. 2023

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Background Hepatoblastoma is the most common primary malignancy of hepatic origin in children, with an estimated incidence of 0.5–1.5 per million children. Hepatoblastoma classically has an intraparenchymal location, and pedunculated hepatoblastoma is a relatively rare entity. Accurate diagnosis can be challenging due to its extrahepatic location and possibly its thin peduncle, which is not easily identified in imaging. Case presentation Here, we report a case of asymptomatic giant palpable hepatoblastoma in the LUQ of a four-month-old male infant, initially suspected of neuroblastoma based on abdominal ultrasound findings. The final diagnosis of giant pedunculated hepatoblastoma was made based on the abdominal CT scan and the diagnosis was confirmed by percutaneous biopsy. Due to the size of the tumor, complete removal of the tumor was not initially possible. Therefore, the patient was treated with several courses of chemotherapy. The tumor was shrunk and then completely removed. The patient was treated, and no complications were found in the 6-month follow-up. Conclusion Pedunculated hepatoblastoma is rare but should be considered as a possibility in the case of a perihepatic mass in a pediatric patient that can be confused with other upper abdominal masses such as an adrenal mass. Therefore, in such cases, we must look for the vascular pedicle in the imaging and keep the AFP check in mind.

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Section: Discussionmentioning

confidence: 99%

Giant pedunculated hepatoblastoma mimicking neuroblastoma in a 4-month-old infant: a case report

et al. 2023

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“…Calcification, necrosis, and vascular invasion may be seen. Congenital HB may be detected using prenatal ultrasound, and such pregnancies may be complicated by polyhydramnios secondary to gastrointestinal compression by the mass, resulting in fetal hydrops [169]. Using CT scans, HB is heterogeneous and hypoattenuating to the surrounding liver parenchyma [170].…”

Section: Imaging Findingsmentioning

confidence: 99%

Update on the Pathology of Pediatric Liver Tumors: A Pictorial Review

Bhagat,

Vij,

Raju

et al. 2023

Diagnostics

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Liver tumors in children are uncommon and show remarkable morphologic heterogeneity. Pediatric tumors may arise from either the epithelial or mesenchymal component of the liver and rarely may also show both lines of differentiation. Both benign and malignant liver tumors have been reported in children. The most common pediatric liver tumors by age are benign hepatic infantile hemangiomas in neonates and infants, malignant hepatoblastoma in infants and toddlers, and malignant hepatocellular carcinoma in teenagers. Here, we provide an up-to-date review of pediatric liver tumors. We discuss the clinical presentation, imaging findings, pathology, and relevant molecular features that can help in the correct identification of these tumors, which is important in managing these children.

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“…Congenital HB may be identified prenatally by maternal ultrasounds in the early third trimester and typically present as a single, solid, and well-circumscribed echogenic lesion [ 47 ]. Pregnancies are complicated by polyhydramnios secondary to gastrointestinal compression from the mass with resultant fetal hydrops.…”

Section: Malignant Tumors In Infants and Early Childhoodmentioning

confidence: 99%

Pediatric Primary Hepatic Tumors: Diagnostic Considerations

2021

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The liver is the third most common site of abdominal tumors in children. This review article aims to summarize current evidence surrounding identification and diagnosis of primary hepatic tumors in the pediatric population based upon clinical presentation, epidemiology, and risk factors as well as classical imaging, histopathological, and molecular diagnostic findings. Readers will be able to recognize the features and distinguish between benign and malignant hepatic tumors within different age groups.

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Prenatal Diagnosis of Congenital Hepatoblastoma

Cited by 3 publications

References 14 publications

Giant pedunculated hepatoblastoma mimicking neuroblastoma in a 4-month-old infant: a case report

Giant pedunculated hepatoblastoma mimicking neuroblastoma in a 4-month-old infant: a case report

Update on the Pathology of Pediatric Liver Tumors: A Pictorial Review

Pediatric Primary Hepatic Tumors: Diagnostic Considerations

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