Prenatal Diagnosis of Congenital Epulis by 2D/3D Ultrasound and Magnetic Resonance

Frisová, V.; Prosova, B.; Mahdian, Nima; Kynčl, Martin; Vlk, R.; Roček, Miloslav

doi:10.1159/000346811

Cited by 8 publications

(13 citation statements)

References 5 publications

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“…A teratoma [3][4][5] (including epignathus 7 ) can present as a mixed solid-cystic structure containing cells from the 3 germ cell layers (primarily containing bone, fat and hair). An epulis, 9 a hamartoma, 15 an encephalocele, [10][11] a nasal glioma 11 will present as a solid, soft tissue lesion. An osteoma 13,14 is recognized by its echogenic bony growth, whereas a dacrocystocoele, 17 lymphangioma 12 or a ranula 19,20 are cystic structures.…”

Section: Discussionmentioning

confidence: 99%

“…This can result in a postnatal emergency, often necessitating ex-utero intrapartum treatment procedure, which requires thorough preoperative planning. [23][24][25] This is commonly required in a teratoma, 3-5 epignathus 7 and foregut duplication cyst 26,27 but less likely in case of an epulis 9 or ranula. 19 Compression of the esophagus may prevent fetal swallowing and result in antenatal complication such as polyhydramnios and preterm delivery.…”

Section: Discussionmentioning

confidence: 99%

“…Cardiac failure, polyhydramnios and hydrops may result. Epulis 9 Gingival granular cell tumour of the upper gum Echogenic, solid; polypoid-like; smooth contour; homogenous, calcifications and cystic components are rare; focal vascularity (feeding vessel may be identified). Usually small-moderate in size, grows during pregnancy, rarely causes adverse fetal outcome.…”

Section: Differential Diagnosismentioning

confidence: 99%

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Prenatal Diagnosis of a Facial Teratoma. A Proposed Approach to Diagnose Prenatal Facial Anomalies

Smet

Shurmer

Kesby

et al. 2020

J of Ultrasound Medicine

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We report on a rare case of a prenatally diagnosed isolated facial teratoma, presenting as an avascular elongated ossified lesion arising from the inferior lateral rim of the orbit. There was no evidence of fetal compromise throughout the course of the pregnancy, which resulted in term delivery of a healthy neonate by elective Caesarean section. We summarize the key features, differential diagnoses, prognosis and management of fetal facial lesions.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Differential Diagnosismentioning

confidence: 99%

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Prenatal Diagnosis of a Facial Teratoma. A Proposed Approach to Diagnose Prenatal Facial Anomalies

Smet

Shurmer

Kesby

et al. 2020

J of Ultrasound Medicine

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“…This swallowing disorder leads to polyhydramniosis in the prenatal period (11). The diagnosis is frequently made after delivery, but cases diagnosed in the prenatal period have been reported in the literature (12,13). Prenatal diagnosis is significant in terms of deciding the mode of delivery and early multi-centered approach.…”

Section: Discussionmentioning

confidence: 99%

A premature newborn with intraoral tumor

Surmeli-Onay

Api

2015

Turk Arch Ped

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Figure 1. Mass obstructing the mouth space nearly completely 353 Diagnosis: Congenital epulisThe mass which had a short handle, erythematous, punctate minimally hemorrhagic areas and a moderately firm consistency was sent for histopathological examination. On macroscopic examination, a creambrown lesion covered with mucosa with dimensions of 2.5 x 2.1 cm was observed and hemorrhage was observed on the surface. The cross sections were solid, brown and elastic. On microscopic examination, a nodular lesion covered with stratified squamous epithelium with diffuse ulcers on the surface which was characterized with small monotonous poligonal cells with large, granular, eozinophilic cytoplasms was observed. These histopathological findings were compatible with congenital epulis (CE). DiscussionCongenital epulis is a rare, benign soft tissue lesion of the newborn generally originating from the alveolar prominence of the maxilla or mandible. CE which is also called congenital granular cell tumor (GCT) was described by Neumann (1) in 1871 for the first time and hundreds of cases have been reported until the present time. Its characteristic property is that it generally originates from the upper chin and has a single, polypoid structure. However, multiple masses have been reported in 10% of the cases (2). Its etiology has not been elucidated yet. It is observed in girls with a higher rate compared to boys (3). The maxilla/mandible ratio is 3:1 and the female/male ratio is 8:1 or 10:1. Although its higher prevalence in girls suggested hormonal impact, the fact that estrogen and progesteron receptors could not be found on tumor cells confuted this assumption. Although malign forms of other GCTs have been observed, no malignancy related with CE has been reported in the literature so far (2, 4). Although spontaneous reduction has been reported in the literature, its treatment generally consists of complete excision of the mass. No recurrence or metastasis has been reported after surgery. The prognosis is excellent (2, 5, 6).Premature delivery has been reported very rarely in hundreds of patients with congenital epulis in the literature (7,8). The fact that our patient was delivered prematurely is the speciality of our case.Con genital epulis for which the biological origin has not been elucidated yet is histologically observed as cell groups in diffuse layers. These cell groups contain round, intense small nuclei and rough granular cytoplasms. Fine vascular plexus is found between the granular cells. This predisposes to hemorrhage in the lesion (9). It is thought that congenital epulis originates from undifferentiated mesenchymal cells, fibroblasts, myofibroblasts, Schwann cells or odontogenix epithelial cells (10).Congenital epulis causes to problems which require urgent intervention related with respiration and nutrition and severe parental anxiety because of the region of origin. Congenital epulis may render feeding impossible by preventing closure of the mouth and swallowing. This swallowing disorder leads to polyhydramnio...

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“…[7] Its association with congenital anomalies such as transverse facial cleft, polydactyl, congenital goiter, and neurofibromatosis [8] and its presence in an in vitro fertilized baby have also been documented. [9] Although prenatal evidence of lesion on routine ultrasound of pregnant mother have been documented, [10] diagnosis of CGCE is by histology, which presents as large sheets of polygonal or rounded cells with a centrally placed small dark basophilic nucleus with an abundant eosinophilic granular cytoplasm. Lesion is often overlined by parakeratinized stratified squamous epithelium with a high degree of vascularity.…”

Section: Introductionmentioning

confidence: 99%

Congenital granular cell epulis: Pattern of presentation in four Nigerian tertiary hospitals

Salami¹,

Akinshipo²,

Oluwakuyide³

et al. 2018

ijmdcr

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This study aims to report seven cases of congenital granular cell epulis (CGCE) diagnosed in four teaching hospitals in Southwestern Nigeria over a period of 8 years. CGCE is a rare lesion that presents exclusively at birth. It is benign, but often presents an unsightly appearance, and may be associated with difficulty in feeding, thus early presentation of cases for treatment. The records of the oral and maxillofacial pathology departments of four Nigerian teaching hospitals were assessed for lesions with histological diagnosis of CGCE. Data inclusive of age, gender, anatomic site, and mode of treatment was retrieved and analyzed with SPSS version 21. Seven cases were identified from the four teaching hospitals. All cases occurred in females with an average period of presentation at 7 days after birth. Most of the cases (71.4%) occurred on the maxillary alveolar ridge. Six cases presented as a single pedunculated or sessile lesion, while in one case, three nodules were seen. Although spontaneous regression has been documented in literature, all our cases had surgical excision under local anesthesia without complications or recurrence. All our cases were diagnosed in females and 71.4% were on the maxillary alveolar ridge.

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Prenatal Diagnosis of Congenital Epulis by 2D/3D Ultrasound and Magnetic Resonance

Cited by 8 publications

References 5 publications

Prenatal Diagnosis of a Facial Teratoma. A Proposed Approach to Diagnose Prenatal Facial Anomalies

Prenatal Diagnosis of a Facial Teratoma. A Proposed Approach to Diagnose Prenatal Facial Anomalies

A premature newborn with intraoral tumor

Congenital granular cell epulis: Pattern of presentation in four Nigerian tertiary hospitals

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