Prenatal Diagnosis of a Fibrosarcoma of the Thigh: A Case Report

Durin, Luc; Jeanne-Pasquier, Corinne; Bailleul, P.; Eboue, Cyril; Aicardi, Stéphanie; Herlicoviez, M.; Dreyfus, Michel

doi:10.1159/000095657

Cited by 13 publications

(6 citation statements)

References 16 publications

(12 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Congenital or infantile fibrosarcoma is an intermediate (rarely metastasizing) neoplasm that occurs in the 1st 2 years of life, and nearly half are diagnosed at birth or antenatally [448][449][450][451][452][453][454][455][456]. Although it is sometimes grouped with fibrosarcomas in the malignant category (see Table 13 and below), it is discussed here in the context of the intermediate tumors.…”

Section: Infantile Fibrosarcomamentioning

confidence: 99%

Fibroblastic and Myofibroblastic Tumors in Children and Adolescents

2012

View full text Add to dashboard Cite

Fibroblastic and myofibroblastic tumors in children and adolescents are a relatively common group of soft tissue proliferations that range from reactive to hamartomatous to neoplastic, with a full spectrum of benign, intermediate, and malignant neoplasms. These lesions are diagnostically challenging because of morphologic and immunohistochemical overlap, despite significant clinical, genetic, and prognostic differences. The fibromatoses are a major subgroup, and all types of fibromatoses can occur in the 1st 2 decades of life. Intermediate and malignant fibroblastic-myofibroblastic tumors are an important group that includes variants of fibrosarcoma and other tumors with recurrent cytogenetic or molecular genetic abnormalities and low metastatic potential. Pathologic examination is enhanced by adjunct techniques, such as immunohistochemistry, cytogenetics, and molecular genetics, although morphology provides the ultimate criteria for a specific diagnosis. This article reviews the clinicopathologic features of fibroblastic and myofibroblastic tumors with an emphasis on the unique aspects of these neoplasms in children and adolescents, the use of diagnostic adjuncts, and differential diagnoses.

show abstract

Section: Infantile Fibrosarcomamentioning

confidence: 99%

Fibroblastic and Myofibroblastic Tumors in Children and Adolescents

2012

View full text Add to dashboard Cite

show abstract

“…Histologically, they are cellular with interlacing fascicles of plump spindle–ovoid cells. When detected prenatally, they appear as a non‐specific vascularized mass, usually affecting a limb, which may clinically suggest hemangioma51–53, or rarely present with metastatic disease51, 52, 54–57. There is an overall 5–25% mortality and 5–50% recurrence risk but it is now recognized that congenital fibrosarcoma is highly responsive to chemotherapy58.…”

Section: Fetal Malignanciesmentioning

confidence: 99%

Metal Ion Coordination to Azole Nucleosides

Müller

Böhme

Lax

et al. 2005

Chemistry A European J

View full text Add to dashboard Cite

To evaluate the possibility of introducing azole nucleosides as building blocks for metal-mediated base pairs in artificial oligonucleotides, imidazole nucleoside, 1,2,4-triazole nucleoside and tetrazole nucleoside have been synthesized and characterized. The X-ray crystal structures of p-toluoyl-protected 1,2,4-triazole and tetrazole nucleosides are reported. Contrary to the situation primarily found for deoxyribonucleosides, the sugar moieties adopt C3'-endo conformations. The acidity of the beta nucleosides increases with increasing number of nitrogen ring atoms, giving pKa values of 6.01 +/- 0.05, 1.32+/-0.05 and <-3, respectively. This decrease in basicity results in a decreasing ability to form 2:1 complexes with linearly coordinating metal ions such as Ag+ and Hg2+. In all cases, the Ag+ complexes are of higher stability than the corresponding Hg2+ complexes. Whereas imidazole nucleoside forms highly stable 2:1 complexes with both metal ions (estimated log beta2 values of >10), only Ag+ is able to reach this coordination pattern in the case of triazole nucleoside (log beta2 = 4.3 +/- 0.1). Tetrazole nucleoside does not form 2:1 complexes at all under the experimental conditions used. These data suggest that imidazole nucleoside, and to a lesser extent 1,2,4-triazole nucleoside, are likely candidates for successful incorporation as ligands in oligonucleotides based on metal-mediated base pairs. DFT calculations further corroborate this idea, providing model complexes for such base pairs with glycosidic bond distances (10.8-11.0 Angstroms) resembling those in idealized B-DNA (10.85 Angstroms).

show abstract

“…The main treatment of congenital infantile fibrosarcoma in the extremity region is surgical excision [ 17 ]. Chemotherapy is given for large non-operable masses to decrease the tumor size before surgical resection and unfortunately, sometimes amputation is needed for a nonfunctional limp or if the tumor is not responding to the chemotherapy [ 17 ].…”

Section: Discussionmentioning

confidence: 99%

Magnetic Resonance Imaging Features of Congenital Infantile Fibrosarcoma

AlQatie,

Abbod,

Alzaid

et al. 2024

Cureus

View full text Add to dashboard Cite

Background Congenital/infantile fibrosarcoma is a rare soft tissue tumor presented in early age of life. It should be considered in the differential diagnosis of the large soft tissue masses especially in the extremities at the age of infancy. These tumors frequently are misdiagnosed at birth as hemangioma. Histologically, they can resemble their adult counterparts and they are characterized by the chromosomal translocation t(12;15) (p13;q25) resulting in the ETV6-NTRK3 gene fusion. Objective A retrospective review of the MRI features of histopathology-proven congenital/infantile fibrosarcoma provides our own institutional experience and supports the limited radiology literature written about this disease. Material and method The list of our patients is obtained after reviewing our radiology and pathology database in the period between June 1st, 2007 and May 31st, 2017 (10 years) at King Faisal Specialist Hospital & Research Center, Riyadh. Phrases used to search in our MRI examinations database are: congenital infantile fibrosarcoma, infantile fibrosarcoma, juvenile fibrosarcoma, soft tissue sarcoma, malignant soft tissue mass, sarcomatous soft tissue mass, fibrosarcoma, spindle cell sarcoma, myomatous sarcoma. Result In our database and picture archiving and communication system (PACS) during the period of the study, the word (fibrosarcoma) was mentioned in the radiology report of 182 patients. Only four cases were histopathologically proven to be a congenital/infantile fibrosarcoma and had completed their own MR exams - three of them were primary/new cases, males with an age range between 0 days and 5 months (median age: 5 months). The fourth case was a female with a history of 1 st presentation at the age of one month and proved by histopathology examination but there was no available imaging at that time; however, tumor recurrence in the same patient was at the age of 4 years with available MR imaging and pathology sample. Conclusion Congenital infantile fibrosarcoma is a rare entity that has no specific MRI findings. However, it should be always considered as part of the differential diagnosis of congenital soft tissue masses with aggressive behavior.

show abstract

Prenatal Diagnosis of a Fibrosarcoma of the Thigh: A Case Report

Cited by 13 publications

References 16 publications

Fibroblastic and Myofibroblastic Tumors in Children and Adolescents

Fibroblastic and Myofibroblastic Tumors in Children and Adolescents

Metal Ion Coordination to Azole Nucleosides

Magnetic Resonance Imaging Features of Congenital Infantile Fibrosarcoma

Contact Info

Product

Resources

About