Prenatal developmental toxicity studies on fumes from oxidised asphalt (OA) in the rat

Boogaard, Peter J.; Buschmann, J.; Fuhst, Rainer; Blümlein, Katharina; Koch, Wolfgang; Schaudien, Dirk; Schwarz, Katharina; McAlinden, Christine; Deferme, Lize; Vaissière, Mathieu; Ketelslegers, Hans B.; Steneholm, Anna

doi:10.1016/j.reprotox.2021.03.003

Cited by 5 publications

(3 citation statements)

References 30 publications

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“…The production and storage of asphalt binders are processes that occur at high temperatures, and in these stages, oxidation reactions of some groups of compounds and production of VOCs may occur . These volatile compounds generated in oxidation, called asphalt fumes, produce air pollutants, which are toxic to human health. , …”

Section: Environmental Impact Of the Asphalt Industrymentioning

confidence: 99%

“…25 The production and storage of asphalt binders are processes that occur at high temperatures, and in these stages, oxidation reactions of some groups of compounds and production of VOCs may occur. 26 These volatile compounds generated in oxidation, called asphalt fumes, produce air pollutants, which are toxic to human health. 27,28 Asphalt binders are also rich in asphaltenes, which cause several problems in oil production and refining, such as clogging of equipment and pipes.…”

Section: Environmental Impact Of the Asphaltmentioning

confidence: 99%

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Characterization of Asphalt Aging by Analytical Techniques: A Review on Progress and Perspectives

2022

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This review describes the chemical composition of asphalt, which is relevant for the development of materials with higher quality and durability. Asphalt aging can occur in the short term (during machining and storage periods) and the long-term (during the time the pavement is exposed to the environment). To understand the effect of aging on the chemical and physical properties of asphalt, we reviewed the short-term (rolling-thin film oven test (RTFOT) and its variations) and long-term (pressure aging vessel (PAV) and its variations) aging methods and the effects of the sun’s ultraviolet radiation (Suntest and its variations). We also explored the main chemical reactions that occur in the aging processes, such as oxidation, polymerization, and aromatization. For a more accurate assessment of the classes of compounds that undergo aging reactions, fractionation techniques have been developed over the years, such as separation of asphalt into saturates, naphthenic-aromatics, resins, asphaltenes, organic sulfides, nitrogenates, and oxygenates, among others. Despite several studies on the theme of asphalt aging, it is still necessary to understand the phenomena that occur in those processes.

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Section: Environmental Impact Of the Asphalt Industrymentioning

confidence: 99%

Section: Environmental Impact Of the Asphaltmentioning

confidence: 99%

Characterization of Asphalt Aging by Analytical Techniques: A Review on Progress and Perspectives

2022

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“…or contain very low concentration of PACs, such as low-boiling petroleum substances, bitumen and oxidized asphalt and also all gas-to-liquid products (synthetic analogues of petroleum substances without aromatic compounds), no developmental effects were observed in rats (Boogaard et al, 2021;Whale et al, 2018). successfully correlated the developmental toxicity and the 3-to 7-ring PAC content of the petroleum substances.…”

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confidence: 85%

Use of new approach methodologies to study the developmental toxicity of polycyclic aromatic hydrocarbons

Fang¹

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Background and aim of the thesisPolycyclic aromatic hydrocarbons (PAHs) make up a large group of organic compounds with thousands of individual chemicals (EFSA, 2008). Their molecular structure contains at least three benzene rings (with only carbon and hydrogen atoms) in linear, angular or clustered arrangements . PAHs are derived from natural-biological or anthropogenic sources . The natural-biological PAHs are generated by plants, algae and microorganism, and are also derived from oil seeps, early diagenesis, forest fires, and volcanoes (Mojiri et al., 2019;. The anthropogenic sources of PAHs are either petrogenic or pyrogenic. Most pyrogenic PAHs are generated by pyrolysis or incomplete combustion of organic matters such as coal, petroleum and wood (Stout et al., 2015). Petrogenic PAHs derive mainly from crude oil and petroleum products such as gasoline, petroleum gas, kerosene, diesel, heavy fuel oil, gas oil, distillate aromatic extract, lubricating base oil, asphalt and paraffin wax . Both pyrogenic and petrogenic PAHs are highly complex materials and their chemical composition can vary substantially.Unsubstituted PAHs are abundant in pyrogenic substances while alkylated PAHs (e.g., monomethylated, dimethylated and ethylated PAHs) account for a relatively large proportion of the PAHs present in the petrogenic substances Sun et al., 2014). This implies that the PAHs present in crude oil and its refined products i.e., petroleum substances, are dominated by alkylated PAHs instead of their unsubstituted/parent PAHs. It is of interest to note that while numerous studies focus on the toxicity of unsubstituted PAHs, limited is known about the toxicity of the alkylated PAHs. However, it was reported that the methylated congeners of some PAHs could induce either higher or lower toxicity compared to their corresponding unsubstituted/parent PAHs . Thus, it can be hypothesized that the position of the methyl substituent on the aromatic ring of PAHs could either increase or decrease their toxicity such as for example their developmental toxicity.Regarding petroleum substances, several in vivo studies have reported that the observed developmental toxicity (e.g., increased resorptions and reduced fetal body weights in rats) of petroleum substances might be related to certain polycyclic aromatic hydrocarbons (PACs) known to be present in some petroleum substances i.e., distillate aromatic extract and clarified slurry oil (Feuston et al., 1997(Feuston et al., , 1989. PACs present in petroleum substances consists of naked/unsubstituted or alkylated PAHs and heterocyclic aromatics (Carrillo et al., 2019;. Whereas for petroleum substances that are devoid of confounding effects of other hazardous chemicals (IARC, 2010; Kennish, 2016). Thus, the definite developmental effects of PAHs, especially individual PAHs including substituted PAHs, on fetuses/embryos upon prenatal exposure remain to be fully elucidated.To date, developmental toxicity studies using experimental animals are mostly limited to studies on the unsubstituted PA...

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Chemical fingerprinting of volatile organic compounds from asphalt binder for quantitative detection

Chang

Long

Wang

et al. 2023

Construction and Building Materials

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Prenatal developmental toxicity studies on fumes from oxidised asphalt (OA) in the rat

Cited by 5 publications

References 30 publications

Characterization of Asphalt Aging by Analytical Techniques: A Review on Progress and Perspectives

Characterization of Asphalt Aging by Analytical Techniques: A Review on Progress and Perspectives

Use of new approach methodologies to study the developmental toxicity of polycyclic aromatic hydrocarbons

Chemical fingerprinting of volatile organic compounds from asphalt binder for quantitative detection

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