Prenatal developmental toxicity of decabromodiphenyl ethane in the rat and rabbit

Hardy, Marcia; Mercieca, Michael D.; Rodwell, Dean E.; Stedeford, Todd

doi:10.1002/bdrb.20237

Cited by 12 publications

(6 citation statements)

References 9 publications

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“…Generally, low toxicity of DBDPE in our findings was consistent with those of previously reported studies (Hardy et al, 2002(Hardy et al, , 2010Wang et al, 2010), especially those on mammalian toxicology. Several studies have been recently reported on the mammalian toxicology of DBDPE.…”

Section: Discussionsupporting

confidence: 93%

“…Several studies have been recently reported on the mammalian toxicology of DBDPE. Hardy et al (2010) found no evidence of prenatal developmental toxicity when treated with DBDPE at dosage levels up to 1250 mg/(kgd) from gestation Day 6 through Day 15 for rats and Day 6 through Day 18 for rabbits. When extending the exposure duration to 28 or 90 d, still no overt toxicity was indicated but hepatotoxicity was induced in rats at similar or lower concentrations (Hardy et al, 2002;Wang et al, 2010;Sun et al, 2014).…”

Section: Discussionmentioning

confidence: 78%

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Neurological responses of embryo-larval zebrafish to short-term sediment exposure to decabromodiphenylethane

Jin

Zhang

et al. 2018

J. Zhejiang Univ. Sci. B

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Decabromodiphenylethane (DBDPE) has been widely used as an alternative flame retardant due to the restriction or phase-out of traditional polybrominated diphenyl ethers (PBDEs), and is of increasing concern regarding its ubiquity, persistence, and potential adverse effects. In the present study, the toxicological effects of DBDPE were evaluated using zebrafish as an in vivo model. Upon being exposed to DBDPE-polluted sediments for a short term, it was found that the mortality and malformation of zebrafish (including edema, bent notochord, and bent tail) were not affected even at the highest concentration tested (1000.0 µg/kg dry sediment). Regarding behavioral responses, it was found that zebrafish larvae of 48 hours post fertilization (hpf) in all groups escaped successfully with a touch to the dorsal fin. However, when exposed to the highest DBDPE concentration, the larvae of 120 hpf exhibited significantly smaller distances as compared to the control. Moreover, the results of the acetylcholinesterase (AChE) activity, the expression levels of two important nerve-related genes, and the cell apoptosis all indicated that DBDPE posed low neurotoxicity in embryo-larval zebrafish. The results in this study shed some light on the potential risks of DBDPE in the real environment and highlight the application of the sediment exposure route in the future.

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Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 78%

Neurological responses of embryo-larval zebrafish to short-term sediment exposure to decabromodiphenylethane

Jin

Zhang

et al. 2018

J. Zhejiang Univ. Sci. B

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“…No evidence of maternal toxicity, developmental toxicity or teratogenicity was reported in rats and rabbits treated with DBDPE at dose levels up to 1 250 mg/kg b.w. per day from gestation day (GD) 6 to GD15 for rats and GD6 to GD18 for rabbits (Hardy et al, 2010).…”

Section: Hazard Identificationmentioning

confidence: 99%

Scientific Opinion on Emerging and Novel Brominated Flame Retardants (BFRs) in Food

2012

EFS2

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EFSA was asked to deliver a scientific opinion on brominated flame retardants (BFRs) other than PBDEs, PBBs, HBCDDs, TBBPA and brominated phenols and their derivatives. The BFRs that are the subject of the current opinion, were classified in groups termed "emerging" and "novel" BFRs. Information on 17 emerging and 10 novel BFRs was collected. The information varied widely for these BFRs. There is a lack of experimental data on physico-chemical characteristics, stability/reactivity and current use and production volume of all the emerging and novel BFRs. Due to the very limited information on occurrence, exposure and toxicity, the CONTAM Panel could not perform a risk characterisation for any of the BFRs considered. Instead, an attempt was made to identify those BFRs that could be a potential health concern and should be considered first for future investigations. For this purpose the Panel first evaluated the available experimental data on occurrence in food, behaviour in the environment and toxicity. Secondly, a modelling exercise was performed focussing on the potential of the emerging and novel BFRs for persistence in the environment and for their possible bioaccumulation potential. There is convincing evidence that tris(2,3-dibromopropyl) phosphate (TDBPP) and dibromoneopentyl glycol (DBNPG) are genotoxic and carcinogenic, warranting further surveillance of their occurrence in the environment and in food. Based on the limited experimental data on environmental behaviour, 1,2-bis(2,4,6-tribromophenoxy)ethane (BTBPE) and hexabromobenzene (HBB) were identified as compounds that could raise a concern for bioaccumulation. For the modelling exercise, the CONTAM Panel selected two environmental characteristics, overall persistence and potential for bioaccumulation, as being most relevant to provide insight into the possibility that emerging or novel BFRs The less well known and less studied BFRs, subject of the current opinion, were grouped into two classes, referred to herein as "emerging" and "novel" BFRs. Emerging BFRs are defined as chemicals which are applied as flame retardants and that have been identified in any environmental compartment, in wildlife, in food or in humans. It should be noted that the definition for the emerging BFRs, used in this opinion, does not imply that there is evidence for an increasing trend in the concentration of these BFRs in the environment, in food or in human samples. Novel BFRs are defined as chemicals applied as flame retardants, with confirmed presence in materials and/or goods in concentrations above 0.1 %, but not identified in environmental samples, wildlife, food or humans. In total, information on 27 BFRs, of which 17 were identified as "emerging" and 10 as "novel", was collected by the CONTAM Panel, and it was noted that the available information varied widely for the various individual BFRs.In general, there is a lack of experimental data on physico-chemical characteristics and stability/reactivity for all the emerging and novel BFRs. This sometimes hampered ...

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“…Previous disposition studies of DBDPE have focused on high dose exposures (Hardy et al, 2002, Hardy et al, 2010, Wang et al, 2010a). However, the effects seen at high doses may not accurately reflect disposition of DBDPE after much lower occupational or environmental exposures.…”

Section: Introductionmentioning

confidence: 99%

The biological fate of decabromodiphenyl ethane following oral, dermal or intravenous administration

et al. 2016

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The disposition of decabromodiphenyl ethane (DBDPE) was investigated based on concerns over its structural similarities to decaBDE, high potential for environmental persistence & bioaccumulation, and high production volume.In the present study, female Sprague Dawley rats were administered a single dose of [14C]-DBDPE by oral, topical, or IV routes. Another set of rats were administered 10 daily oral doses of 14C]-DBDPE. Male B6C3F1/Tac mice were administered a single oral dose.DBDPE was poorly absorbed following oral dosing, with 95% of administered [14C]-radioactivity recovered in the feces, 1% recovered in the urine and less than 3% in the tissues at 72 h. DBDPE excretion was similar in male mice and female rats. Accumulation of [14C]-DBDPE was observed in liver and the adrenal gland after 10 daily oral doses.The dermis was a depot for dermally applied DBDPE; conservative estimates predict ~14±8% of DBDPE may be absorbed into human skin in vivo; ~7±4% of the parent chemical is expected to reach systemic circulation following continuous exposure (24 h).Following intravenous administration, 6% of the dose was recovered in urine and 28% in the feces, while ~70% of the dose remained in tissues after 72h, with the highest concentrations found in the liver (42%) and lung (17%).

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Prenatal developmental toxicity of decabromodiphenyl ethane in the rat and rabbit

Abstract: Based on these results, no evidence of maternal toxicity, developmental toxicity, or teratogenicity was observed in rats or rabbits treated with DBDPEthane at dosage levels up to 1,250 mg/kg-day.

Cited by 12 publications

References 9 publications

Neurological responses of embryo-larval zebrafish to short-term sediment exposure to decabromodiphenylethane

Neurological responses of embryo-larval zebrafish to short-term sediment exposure to decabromodiphenylethane

Scientific Opinion on Emerging and Novel Brominated Flame Retardants (BFRs) in Food

The biological fate of decabromodiphenyl ethane following oral, dermal or intravenous administration

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